Da-Neng Wang

Da-Neng Wang

@danengw.bsky.social

Structural biologist, professor, NYU School of Medicine. Alum of: Skirball Institute, EMBL-Heidelberg, Univ Stockholm, Acad Sin, NEU. Personal account. https://scholar.google.com/citations?user=lX2sB0sAAAAJ&hl=en

310 followers197 following38 posts

Da-Neng Wang reposted

Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc

nyti.msDid Anthropic’s A.I. Really Make a Scientific Discovery on Its Own? (Gift Article)An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.

Da-Neng Wang reposted

"White House Moves to Take Control of N.I.H. Grants" [everybody up in arms, as they should be, but for those who have been paying close attention, this has pretty much already happened - the realization just hasn't sunk in yet] www.nytimes.com/2026/09/20/s...

nytimes.comWhite House Moves to Take Control of N.I.H. Grants (Gift Article)Federal officials are drafting an executive order that would place grants under review by an outside panel, the latest effort to redirect billions of dollars in research spending.

Da-Neng Wang reposted

Da-Neng Wang reposted

The 2026 K. H. Kuo Symposium of Cryo-Electron Microscopy was held in Beijing, August 20-25. Organized by Qiang Guo, Ning Gao, Leifu Chang, Peijun Zhang and Yifan Cheng, the symposium was a great success. Highlights included the Kuo Award Lectures delivered by Chris Russo and Ellen Zhong.

Da-Neng Wang reposted

Da-Neng Wang reposted

Da-Neng Wang reposted

Da-Neng Wang reposted

Fun fact: Human NaCT/SLC13A5's mechanism for coupling sodium & substrate co-transport is distinct from its bacterial homolog VcINDY! A fascinating question to tease apart with @danengw.bsky.social and colleagues at NYU School of Medicine!

bioRxiv Biophysics@biorxiv-biophys.bsky.social

Structures of the human sodium-citrate cotransporter NaCT with and without substrates https://www.biorxiv.org/content/10.64898/2026.07.08.737274v1

Da-Neng Wang reposted

Da-Neng Wang reposted

Honored to be elected to EMBO,together with Manu, Julian and ex-benchmate @wojtekgalej.bsky.social. I’m grateful to all past and present Iab members for their amazing work and support from colleagues, mentors and family over the years.

Congratulations to LMB Group Leaders Emmanuel Derivery, Kelly Nguyen and Julian Sale, who have all been elected members of @EMBO.org! Read more about their research at the LMB here: mrclmb.ac.uk/news-events/... #LMBNews @deriverylab.bsky.social @kellythd-nguyen.bsky.social @juliansalelab.bsky.social

Da-Neng Wang reposted

Outstanding NYT opinion piece by @jmcoller.bsky.social that succinctly and clearly makes the case for NIH- and NSF-supported fundamental research. Great piece of writing that highlights much of what’s at stake in current research environment

Victor Ambros@vambros.bsky.social

A column by Jeff Coller: “The Science That Turned Lizard Venom Into GLP-1s Is Under Attack” www.nytimes.com/2026/06/20/o...

Da-Neng Wang reposted

Here's an excellent guide to comment on the OMB's (and potentially catastrophic) rule changes: elizabethginexi.substack.com/p/what-we-ne... By the way, this is not limited to US citizens, anyone can explain how valuable and important US federal funding has been to scientific progress worldwide.

elizabethginexi.substack.comWhat We Need to do NEXT: OMB’s Proposed Federal Financial Assistance Rule (OMB-2026-0034)What OMB’s Proposed Federal Financial Assistance Rule Means in Practice
Levental Lab@leventallab.bsky.social

The new OMB rules will be a disaster for American science. Please take a few moments to read up and post a comments. Click the link below, it’s easy, fast, and the most important thing you can do to support our community.

Da-Neng Wang reposted

Breaking news: Indiana University plant microbiologist Roger Innes has been locked out of his laboratory by the school in response to a request by one of his federal funders. The move comes after Innes complained about the government’s prosecution of Chinese postdocs. https://scim.ag/4tsDqRr

scim.agAfter USDA request, Indiana plant biologist locked out of lab by schoolMove comes after Roger Innes complained about the government’s prosecution of Chinese postdocs

Da-Neng Wang reposted

This is an absolute travesty and this is out of control

Science Magazine@science.org

Breaking news: Indiana University plant microbiologist Roger Innes has been locked out of his laboratory by the school in response to a request by one of his federal funders. The move comes after Innes complained about the government’s prosecution of Chinese postdocs. https://scim.ag/4tsDqRr

Da-Neng Wang reposted

Time for a new edition of Canadian biochemist and medical researcher extraordinaire Maud Menten (1878-1960), 🐡🧪👩🏼‍🔬 #histsci coauthor of the Michalis-Menten equation, inventor of the azo-dye coupling which was the first example of enzyme histochemistry for imaging tissues and the first 🧵

Da-Neng Wang reposted

The peer reviewed version is out. Our study suggests this process is not limited to a single dimer architecture: we identified an additional dimeric arrangement, pointing to greater structural diversity in stress-induced ribosome hibernation-like states. doi.org/10.1093/nar/...

doi.orgrRNA expansion segments mediate ribosome dimerization as a conserved stress responseAbstract. Inhibition of messenger RNA translation is a common feature in proteostatic stress cellular responses. Puromycin, a widely used compound for stud
qiangguo.bsky.social@qiangguo.bsky.social

Excited to share our new study: rRNA expansion segments are not passive structural elements — they mediate hibernating ribosome interfaces and reshape translation under stress. www.biorxiv.org/content/10.6...

Da-Neng Wang reposted

En route to share our latest work on the conformational landscape of opioid receptor activation. Grateful to my friend and collaborator, Dr. Susruta Majumdar, for the invitation—looking forward to connecting with everyone at WashU @washumedicine.bsky.social!

Da-Neng Wang reposted

Physicist Chien-Shiung Wu died #OTD in 1997. She conducted the Wu experiment (proving parity isn't conserved) for which her male colleagues won the 1957 Nobel Prize in Physics. Her role wasn't publicly honored until she was awarded the inaugural Wolf Prize in 1978. #WomenInSTEM #MatildaEffect

Da-Neng Wang reposted

We’re hiring! Our group at CSHL has openings for postdoctoral fellows in structural biology with a focus on ion channels and receptors in neurotransmission and cancer immunology. Join and pursue unique, cross-disciplinary science to boost your career. jobrxiv.org/job/cold-spr...

jobrxiv.orgPostdoctoral Position in Membrane Protein Biology & Ion Channel PhysiologyPost a job in 3min, or find thousands of job offers like this one at jobRxiv!

Da-Neng Wang reposted

Sad news on the passing of Prof. Andreas Engel, a pioneer in the field of cryo-EM (shared with the 3DEM community by Henning Stahlberg). Andreas' kindness, warmth, and enthusiasm for science and his colleagues will be missed.

Da-Neng Wang reposted

I’m excited to share new work out of the lab at @NYULangone led by @kenjifujihara.bsky.social ! We took a first principles approach to evaluating @ferroptosis induction for cancer therapy via targeting the SLC7A11-glutathione-GPX4 axis. www.biorxiv.org/cgi/content/...

biorxiv.orgSystematic Evaluation Defines the Limits of Ferroptosis in Cancer TherapyFerroptosis is a cell death mechanism characterized by the accumulation of iron-catalyzed lipid peroxides in membrane lipid acyl chains and subsequent loss of membrane integrity.1 Despite thorough investigation of its mechanisms in cultured cells, induction of ferroptosis has unresolved clinical utility in cancer therapy. Here, we systematically evaluate ferroptosis induction via multiple mechanisms, in both cell and tumor models, using focused genetic screens, genetic loss-of-function systems, and pharmacological perturbations. Through this analysis we identify cancer cell line subsets with distinct responses to canonical ferroptosis inducers and suppressors and define the underpinnings of each. Inhibition of central in vitro ferroptosis suppressors GPX4, GCLC, or SLC7A11 across these multiple models fails to impact established tumor growth. In contrast, deficiency in the cytosolic thioredoxin reductase and pharmacologic GCLC inhibition potently induces tumor regression and triggers a form of non-ferroptotic cell death regulated by cystine availability and translation. These analyses further reveal that the principal essential function of environmental cystine in cultured cells is to support selenoprotein function, identified through investigating our finding that beta-mercaptoethanol supports exponential growth in cystine-free conditions. Thus, while ferroptosis activation may be efficacious alone or in combination with other therapies in specific tumor contexts, cell culture systems greatly overestimate the potential anti-cancer effects of ferroptosis induction via the GPX4 axis. ### Competing Interest Statement The authors have declared no competing interest. NIH Common Fund, R01CA286141, R01GM132491, P30CA016087

Da-Neng Wang reposted

We often get questions about the ins-and-outs of Presubmission Enquiries when engaging with scientists. Are they important? Will they help my paper get sent for review? Can they benefit me? If you're curious as well, please check out our editorial in the Feb issue!

Nature Biomedical Engineering@natbiomedeng.nature.com

Excited to share the February issue! In addition to great research content, we also have an editorial that clarifies how we think about the Presubmission Enquiry at nBME. www.nature.com/natbiomedeng...

Da-Neng Wang reposted

Da-Neng Wang reposted

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

mrc.tal.netResearch Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research CouncilLocation: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55

Da-Neng Wang reposted

Jane changed how I both think about and teach biochemistry.

Admirable Women@admirablewomen.bsky.social

Jane Richardson was born #OTD in 1941 + Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures) + MacArthur Fellow, 1985 + Elected, Nat'l Academy of Sciences, 1991 + President, Biophysical Society, 2012 #WomenInSTEM