Mike Ando

There has been enough interest that we are on to Microscopy Starter Pack #2. Still open to who to include, including yourself! go.bsky.app/DA4LAjJ

Since this year #NobelPrize is for #optogenetics, here is one of my favorite systems, the optoRas. Originally designed for neutrophils, I adapted this to my embryonic myeloid cells! I use it to induce a new protrusion and drives this EM cell to go backward. #MicroscopyMonday

Writing unreadable code is now a metric of success.

Happy #FluorescenceFriday! Our #CellLineOfTheWeek is PCNA - illuminating a protein involved in DNA replication and repair! Our cell lines & plasmids are openly available to accelerate scientific discovery: https://bit.ly/3MRCl60 📦 @coriellinstitute.bsky.social and @addgene.bsky.social

arXiv has updated our policy on rate limiting for all submitters. This update was made to fairly distribute moderator time & support the arXiv community of staff, volunteers, readers & authors. Please read our announcement to learn more: https://blog.arxiv.org/2026/10/01/updated-rate-limit-policy/

🎃Behold FrankenPumpkin!🎃 I filled a flat bottom flask with chlorophyll extracted from algae.🦠UV light produced the red fluorescence. Jordan Tanen drew the pumpkin face.🖊️ #FluorescenceFriday #SciArt #SciComm #RealTimeChem #ChemArt

Excited to share a preprint of my main PhD work in @nickpolizzi.bsky.social's lab - introducing LUCI-tag, a new orthogonal self-labeling protein tag based on K-Ras(G12C) and its covalent inhibitors! www.biorxiv.org/content/10.6... (1/16)

www.biorxiv.org/content/10.6...

That the Oxford comma is essential, and I will add it to all your manuscripts.

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Day 3 of acute #Toxoplasma infection - parasites dividing snugly between the TWO nuclei of one skin cell. And no, binucleation is not an AI artifact. Unlike the 1st place #NikonSmallWorldinMotion 🟦 Parasite shell (GAP45) 🟨🟧🟥🟪 DNA (depth colour-coded) Zeiss LSM980, 100x #Microscopy #Science

that scene from the matrix except it's me reading articles, talk slides, PR descriptions, saying "that's Claude", "that's GPT", "that's Claude", "Claude", "GPT", ...

I've unfortunately been cursed by an evil wizard so that if I ever skip any talk at a conference, the very next person I chat with and ask "and what do you work on?" will turn out to have been the speaker

"I’m saying that I would personally mouth-pipette a solution of pure chloroform right now, today, in front of God and the NIH Director and the entire Office of Research Safety, if it meant a young scientist in my department could get a payline above 20%." substack.com/home/post/p-...

🚨New release: NGFF specification 0.6 🚨 Last week, we formally released the latest version of the NGFF specification: 0️⃣.6️⃣( ngff.openmicroscopy.org/specificatio...) Let's take a small tour through the things possible with #ome-zarr 0.6 now that this is out! 👇

What if any dataset, any size, any number of dimensions, opened in a browser tab from a link? 🔬🧪💻 Luxar is out today: write it in Python, share it as a link, explore it in any browser. Open source. 🧵 @biohub.org Preprint: doi.org/10.5281/zen... Code: github.com/royerlab/luxar

2023: 8,039 proposals 2024: 10,360 proposals 2025: 17,066 proposals 2026: 21,627 proposals Something's gotta give

Colley Hill, Surrey: coffee break from birding the steep scrub. Love the plaque on the bench I’m sitting on

PROPOSAL: an a capella group that sings about low carb diets The Key Tones

Happy #MicroscopyMonday. I found this very pretty COS-7 cell expressing LifeAct-mCherry from my old data. Look at how dense its actin network is. Also, many of the moving dots are endosomal to seemingly push them through the cytoplasm, similar to actin comet tail, but just a lot shorter.

Nice talk, really perfect for teaching Everything you've always wanted to know about #AlphaFold, iPTM, PAE, pLDDT, and ipSAE but were afraid to ask

Ca. 1/10 of randomly perturbed (with a "single-atom change") parent molecules had a >10x increased potency in experimental tests I wonder for how many iterations one could increase affinity in this way?

Humaning.

In light of this growing controversy, I would like to direct attention to the stunning videos 2-31! www.nikonsmallworld.com/galleries/20...

A paper is finished when the embarrassment of submitting it becomes smaller than the embarrassment of still working on it

The #microscopy community has serious concerns about this year’s winning #NikonSmallWorld in Motion video. @healthcare.nikon.com, could you please comment on the raw data and acquisition process to clarify whether AI was used? Transparency would help maintain confidence in the competition.

Pretty funny

I love overly honest READMEs

People are using AI to impersonate real science journalists. And one even got PUBLISHED. In Science. www.linkedin.com/posts/caroli...

found at ucsf

A cell dividing into two new daughter cells photographed through a microscope. #CellBiology

chaos from bouncing a ball in a circle- at each point, I simulate a bunch of futures with slightly different velocities- showing how predictable the system would be with measurement error. The system seems to move between Stable Eras and Chaotic Eras, where it is hard to predict four bounces ahead

Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)

mathematicians now feel like they have to be secretive about what they do in case it gets stolen by AI. graph theorists arent too worried about this though because they’ve already been doing discreet mathematics

Yep, sure, I trust you 1000%. #SupplementsSaga #chemchat #chemsky

Ten years ago Tami, Roy, and I released a movie we made of antibiotic resistance evolving in real time. I thought maybe a couple thousand people tops would see it. I couldn't have imagined it would be seen millions of times, and be taught from middle school through the graduate level worldwide

Do large language models actually understand the world, or are they just very good at pretending? Does it even matter? Our recent Royal Society special issue explores this: royalsocietypublishing.org/rsta/issue/3...

TIL the Japanese soft serve place near me offers Lactaid and honestly? Brilliant

Future me watching temporary -productivity-burst me commit to meetings and calls.

PAUL: What’s in the box? REVEREND MOTHER: Pain. [PAUL hesitantly puts his hand in the BOX, then FROWNS IN CONFUSION. He pulls out A BAGUETTE.] REVEREND MOHER: Hōn hōn,

💧◀️💧Diffusion in reverse!💧◀️💧 I added fluorescein & rhodamine B to a water bath under UV illumination. #FluorescenceFriday #SciArt #SciComm #RealTimeChem #Chemistry

Really happy to see this work from the Shapiro lab. New colleagues in an exciting new field!

Darth Melanogaster

We wrote a tutorial guide on voltage imaging, now out in Neuron: authors.elsevier.com/a/1nlgh3BtfH... Indicators, microscopes, and software have all advanced to the point that it's not so hard -- you can now directly watch the electrical activity of neurons in live animals or in culture.

Happy #FluorescenceFriday! ✨ It's the glue that holds us together, but it looks like a pair of angel wings to me. 👼 This beautiful meshwork of extracellular matrix surrounds the developing tissues of a quail embryo, helping guide cells as they build the body. 📷 @wangjianxiong.bsky.social 🔬

While waiting for the manuscript to be uploaded on bioRxiv, here some sneak peek #FluorescenceFriday