Eelco Tromer

Eelco Tromer

@eelcotromer.bsky.social

NWO-Veni Fellow @GBB Rijksuniversiteit van Groningen | eukaryotic diversity | chromosome segregation | evolutionary cell biology | exploring meiosis

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Eelco Tromer
@eelcotromer.bsky.social

#EvoChromo ciliate kinetochores @maxraas.bsky.social @kopslab.bsky.social . Previous work w\ @jvhooff.bsky.social : tinyurl.com/y5h4ehnt showed a lack of Tetrahymena kinetochore complexity. Replacement, simplification or missed homologies? All of the above? - check out our pre-print tiny.cc/hp8w001

Max Raas@maxraas.bsky.social

Our story on the kinetochore composition of the ciliate Tetrahymena thermophila is out now on bioRxiv! We find surprisingly many orthologs of conventional kinetochore components, but also components that have very different evolutionary origins. A 🧵 (1/11) Check it out here: tinyurl.com/4ectm9x4

tinyurl.comtinyurl.com

Eelco Tromer reposted

Reese Richardson
@reeserichardson.bsky.social

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

Eelco Tromer reposted

Clinton Lau
@ckylau.bsky.social

Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6...

Eelco Tromer reposted

Nilsson lab
@nilssonlab.bsky.social

Happy to see our work on defining a dependency map of short linear motifs out. We use base editing screens to install more than 80000 mutations into SLiMs in more than 4000 proteins to determine their contribution to cell fitness. www.nature.com/articles/s41...

nature.comA proteome-wide dependency map of protein interaction motifs - Nature Structural & Molecular BiologyAmbjørn and Meeusen et al. functionally characterize all reported and a comprehensive set of predicted short linear motifs (SLiMs) using base-editing screens, identifying 450 reported and 264 predicte...
Eelco Tromer
@eelcotromer.bsky.social

Now in Nature Comms w/ @ritatewari.bsky.social, Pushkar Sharma & @ryanase.bsky.social (thanks!). Aurora kinases fascinate me: single ancestor - parallel duplications in eukaryotes - paralogs with distinct functions. ARK1 is the CPC Aurora in the malaria parasite. rdcu.be/e5NRT #plasmodium #mitosis

rdcu.bePlasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complexNature Communications - This study reveals that the malaria parasite Plasmodium uses a unique Aurora kinase complex to control cell division. This divergent machinery regulates spindle formation...
Eelco Tromer@eelcotromer.bsky.social

New work on ARK1 (AURKB?) in Plasmodium (malaria parasite) with @ritatewari.bsky.social and Pushkar Sharma. CPC in Plasmodium is (ofcourse..) different compared to conventional models: two INCENPs, no borealin/survivin - mainly at spindle microtubules/MTOCs. Special thanks to @ryanase.bsky.social!

Eelco Tromer
@eelcotromer.bsky.social

We're on a roll here. Check out this cool paper by @scienceleah.bsky.social et al. on not one, but two types of sperm (!) in the silk worm Bombyx mori. Happy to have contributed. #meiosis4ever

Leah Rosin@scienceleah.bsky.social

New paper from the Rosin lab in collaboration with the Hawley lab 🎉 Spearheaded by postdoc Leif Benner. We use imaging and RNA-seq to better understand apyrene meiosis. Programmed meiotic errors facilitate dichotomous sperm production in the silkworm, Bombyx mori. www.pnas.org/doi/10.1073/...

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Eelco Tromer reposted

Kops Lab
@kopslab.bsky.social

As a cell biology lab, we acknowledge the decades-long impressive efforts to uncover evolutionary relationships using advanced phylogenomics methods. These approaches undergo continuous improvements that lead to adjustments of data interpretation, as is the case in every scientific field. (1/3)

Bungo Akiyoshi@bungoakiyoshi.bsky.social

BTW when I talked to a cell biologist this week and explained that bacterial-origin proteins were used to determine the root of the eukaryotic tree of life, the person was surprised by that approach. So it's not just me who has issues with this approach.

Eelco Tromer
@eelcotromer.bsky.social

Perpetually in awe of the astonishing creative capacity of retrotransposons in eukaryotic cell biology — makes you wonder what remarkable, still-hidden origin stories centromeres across the tree of life carry.

Max Haase@maxhaase.bsky.social

Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14

nature.comAncient co-option of LTR retrotransposons as yeast centromeres - NatureEvolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Eelco Tromer reposted

Max Raas
@maxraas.bsky.social

Recently, a Hypothesis was posed in @jcellsci.bsky.social in which the root of eukaryotes was placed between kinetoplastids and all other eukaryotes. From this, it was implied that LECA did not have a kinetochore. We argue this is highly unlikely. A 🧵(1/12) Read our reply here: tinyurl.com/n87myhpr

tinyurl.comThe LECA had a conventional kinetochore and the kinetoplastid kinetochore is a derived feature – a critical evaluation of Akiyoshi, 2025Summary:Akiyoshi, 2025 presented a hypothesis with implications for the early evolution of eukaryotes and eukaryotic cell division machinery. In this Correspondence, the authors conclude that this hyp...
Eelco Tromer
@eelcotromer.bsky.social

Some light reading for the holidays :). Let us know what you think.

Gautam Dey@gautamdey.bsky.social

Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍 W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social journals.biologists.com/jcs/article/...

journals.biologists.comEvolutionary cell biology comes of ageSummary: This Perspective discusses how the discipline of evolutionary cell biology, by integrating evolutionary theory, comparative physiology and modern molecular approaches, works to understand how...

Eelco Tromer reposted

Max Fürst
@maxfus.bsky.social

New preprint🚨 Imagine (re)designing a protein via inverse folding. AF2 predicts the designed sequence to a structure with pLDDT 94 & you get 1.8 Å RMSD to the input. Perfect design? What if I told u that the structure has 4 solvent-exposed Trp and 3 Pro where a Gly should be? Why to be wary🧵👇

Eelco Tromer
@eelcotromer.bsky.social

New work on ARK1 (AURKB?) in Plasmodium (malaria parasite) with @ritatewari.bsky.social and Pushkar Sharma. CPC in Plasmodium is (ofcourse..) different compared to conventional models: two INCENPs, no borealin/survivin - mainly at spindle microtubules/MTOCs. Special thanks to @ryanase.bsky.social!

Ryuji Yanase@ryanase.bsky.social

Pleased to share our new preprint: "Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex". Many thanks to our collaborators. @ritatewari.bsky.social @eelcotromer.bsky.social @davidguttery.bsky.social www.biorxiv.org/content/10.1...

Eelco Tromer reposted

Leah Rosin
@scienceleah.bsky.social

So excited to share this preprint from the Rosin lab in collaboration with the Hawley lab and @eelcotromer.bsky.social on moth spermatogenesis! We investigate the meiotic errors that occur during the formation of apyrene sperm (that have no DNA) in silkworms! www.biorxiv.org/content/10.1...

biorxiv.orgProgrammed meiotic errors facilitate dichotomous sperm production in the silkworm, Bombyx moriThe goal of meiosis is typically to produce haploid gametes (eggs or sperm). Failure to do so is catastrophic for fertility and offspring health. However, Lepidopteran (moths and butterflies) males pr...
Eelco Tromer
@eelcotromer.bsky.social

Happy to see our work published and glad to have contributed together with @maxraas.bsky.social ! Looking forward to all the projects that will come out of this work!

Laura Eme@lauraeme.bsky.social

Excited to share our new paper in @cellreports.bsky.social that reshapes our understanding of chromosome organization's deep evolutionary roots! Our work dives into the origins of the machinery that structures our very genomes. 🔗: doi.org/10.1016/j.ce... #Genomics #Evolution #CellBiology #LECA

Eelco Tromer reposted

Max Haase
@maxhaase.bsky.social

It’s out! The evolutionary origins of yeast point centromeres uncovered! “Ancient co-option of LTR retrotransposons as yeast centromeres” www.biorxiv.org/content/10.1...

biorxiv.orgAncient co-option of LTR retrotransposons as yeast centromeresThe evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...

Eelco Tromer reposted

Snezhka Oliferenko
@alebenoit.bsky.social

OMG IT IS OUT EUKARYOTIC HOPANOIDS DESERVE ALL CAPS www.nature.com/articles/s41...

nature.comHorizontal acquisition of prokaryotic hopanoid biosynthesis reorganizes membrane physiology driving lifestyle innovation in a eukaryote - Nature CommunicationsHorizontally transferred genes must be integrated into host biology. Here, the authors show that the domestication of bacterial hopanoid synthesis has rewired lipid metabolism of a eukaryote leading t...

Eelco Tromer reposted

Bungo Akiyoshi
@bungoakiyoshi.bsky.social

I am happy to share a preprint on the marine plankton project I started one year ago (thanks to Julius and Drahomira's help) www.biorxiv.org/content/10.1...

biorxiv.orgDiscovery of unique mitotic mechanisms in Paradiplonema papillatumDiplonemids are highly diverse and abundant marine plankton with significant ecological importance. However, little is known about their biology, even in the model diplonemid Paradiplonema papillatum ...
Bungo Akiyoshi@bungoakiyoshi.bsky.social

So I started working on a marine plankton called Diplonema papillatum, a non-traditional model of diplonemids (which turned out to be very abundant and diverse in the ocean). Everything is difficult! But it is so much fun to try to explore unknown unknowns

Eelco Tromer reposted

Carlos Santana Molina
@santanamolina.bsky.social

Asgardarchaea & Alphaproteobacteria: key players for the assembly eukaryotic central carbon metabolism! Our new study reveals their gene contributions to glycolysis & TCA cycle, supporting synthrophic scenarios of eukaryogenesis. rdcu.be/eb0aK

rdcu.beChimeric origins and dynamic evolution of central carbon metabolism in eukaryotesNature Ecology & Evolution - Analysis of the eukaryotic gene repertoires mediating central carbon metabolism identifies ancestral contributions from Alphaproteobacteria, Asgardarchaeota and...

Eelco Tromer reposted

🧬Jacob L Steenwyk
@jlsteenwyk.bsky.social

Have questions about #bioinformatics, #genomics, #evolution or stuck on a project? 🧬💻 I want to help! Happy to discuss data, figures, writing, academia/industry or chatting just for kicks—no strings attached Drop questions below, DM, or schedule a meeting Science together is better than alone 🙌

Eelco Tromer reposted

Jolien van Hooff
@jvhooff.bsky.social

Online: our evolutionary interrogation of eukaryotic Structural Maintenance of Chromosomes (SMC) complexes @maxraas.bsky.social @eelcotromer.bsky.social @lauraeme.bsky.social #SMCcomplexes #eukaryogenesis #LECA #condensin #cohesin #evolutionarycellbiology #chromatin 🧵(1/6) doi.org/10.1101/2024...

doi.orgShaping up genomes: Prokaryotic roots and eukaryotic diversification of SMC complexesbioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Eelco Tromer reposted

Bungo Akiyoshi
@bungoakiyoshi.bsky.social

A new preprint from our group in collaboration with @jvhooff.bsky.social and @eelcotromer.bsky.social. We discovered that trypanosomes have (a zombie of) Bub1-Bub3 despite the fact that tryps do not have a canonical spindle checkpoint! This is a team work involving Dan, WillC, Midori and Patryk

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social

Kinetoplastid kinetochore proteins KKT14-KKT15 are divergent Bub1/BubR1-Bub3 proteins https://www.biorxiv.org/content/10.1101/2024.01.04.574194v1

biorxiv.orgKinetoplastid kinetochore proteins KKT14-KKT15 are divergent Bub1/BubR1-Bub3 proteins https://www.biorxiv.org/content/10.1101/2024.01.04.574194v1 Faithful transmission of genetic material is crucial for the survival of all organisms. In many euka

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