Philadelphia Neuroscience Professor obsessed w/dentate gyrus, mentoring, unsweet soymilk. Opinions & bad jokes are mine not my employerβs. She/her/cat.
https://sites.google.com/view/eischlab
Pics: 75% my smiling face, desk, laptop, blue sky with clouds
Want to chase memory engrams with us? Our NIMH-funded lab studies how LEC inputs shape dentate gyrus engrams. Seeking a postdoc (US work authorization required) to apply with me for CHOP's 3-yr SPAR Fellowship. Apply by Nov 20, earliest possible start July 2027. DM me π§ π§ͺ please RT!
Classic and novel features of the dentate gyrus vascular niche quantified through 3D vessel reconstruction https://www.biorxiv.org/content/10.64898/2026.10.20.760295v1
A study in Nature Neuroscience identifies a secreted phospholipase in the hippocampal dentate gyrus that mediates an aging-sensitive compensatory mechanism promoting cognitive resilience and neuroprotection. go.nature.com/3WgXLy3#Neuroskyence π§ͺ
A paper in Nature Medicine presents a device platform that converses with patients to help them manage their epilepsy. In a small test, patient feedback helped the system improve seizure detection, cutting false alarms by about 80 percent. go.nature.com/489Oo5X#medsky π§ͺ
How does the brain represent symbolic integers and fractions? This study shows that educated adults process both integers and fractions within a shared, topographic map, indicating that the brain integrates numerical concepts to compare magnitudes.
π§ͺ #NeuroSky#math#numerosityplos.io/4jveiIp
Physicist William Higinbotham was born #OTD in 1910. During the Manhattan Project he was the Electronics Group leader at Los Alamos.
In 1958, while working at Brookhaven Lab, he invented one of the first video games: βTennis for Two.β It ran on an oscilloscope! π§ͺ βοΈ
Image: Brookhaven National Lab
Billions of our hard earned tax dollars that were meant for science funding went unspent.
The money will be spent on whatever Trump's priorities are, not basic research.
Brought to you from party of waste, fraud of abuse.
π§ͺ cen.acs.org/policy/resea...
New insights on CAR T cell therapy in recurrent GBM reveal that the endogenous immune compartment plays a critical role in response, impacting tumor reduction & survival. PMID:42296961, Cell 2026, @Cellhttps://www.cell.com/cell/fulltext/S0092-8674(26)00585-4#Medsky#Pharmsky#RNA#ASHG#ESHG π§ͺ
Orexin agonists have been approved for the treatment of a type of narcolepsy. A feature in Nature reports on how they could also treat conditions across the health spectrum, much like what has happened with GLP-1 drugs. #medsky π§ͺ
New study: Integrin-Ξ±8βΊ mesenchymal stem cells in the bone marrow play key roles in maintaining hematopoietic stem cell function. Depleting these cells decreases HSC numbers and activity. PMID:42409817, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75276-2#Medsky#Pharmsky#RNA π§ͺ
A 75,000-year-old Neanderthal from Shanidar Cave, Iraqi Kurdistan, shows evidence of a potentially lethal spear wound, offering rare insight into violence among our ancient relatives. The findings are published in Scientific Reports. π§ͺπΊ
Over 2,700 human mRNA 3' UTRs show conserved sequences that regulate proteins with long intrinsically disordered regions (IDRs). KDM6B 3' UTR alters JMJD3 folding, enhancing IDR interactions, therebyβ¦ PMID:42259285, Cell 2026, @Cellhttps://www.cell.com/cell/fulltext/S0092-8674(26)00576-3#Medsky π§ͺ
Facial biomarker model of #aging & #cancer#mortality risk
www.thelancet.com/journals/lan...
β highest-risk quartile had > 3X mortality of lowest
β could enhance risk stratification when traditional biomarkers unavailable
#health#research#technology π§ͺππ€³π¬πΈ
Researchers analyzed 17 visual pigments in the mantis shrimp eye, discovering two red-light-absorbing proteins that can switch on and off using different wavelengths of light and that could potentially serve as molecular switches to modulate disease signaling pathways. https://bit.ly/4i0dZnN π‘ βοΈ π§ͺ
π§ͺA new study from our lab! Led by @luisaguirre.bsky.social: we analyzed 383 pollination, seed-dispersal & hostβparasite networks worldwide.
Climate mostly shapes network structure, but human impact hits bird- and insect-mediated networks hardest.
π doi.org/10.1111/geb.70246#Ecology#Biogeography
The night sky in Vincent van Goghβs painting The Starry Night may have been inspired by a celestial arrangement visible before dawn on 22 July 1889, according to research in Scientific Reports. The authors argue that the conventional June dating of the work should potentially be reconsidered. ππ§ͺ
Transposable elements, making up ~50% of mammalian genomes, crucially influence gene expression, genomic evolution, and disease via specific regulation, despite losing mobility. PMID:42276034, Cell 2026, @Cellhttps://www.cell.com/cell/fulltext/S0092-8674(26)00520-9#Medsky#Pharmsky#RNA#ASHG π§ͺ
Hereβs my piece of having SciAm kill an urgent story of mine after their acquisition.
I knew Springer Nature likely sold SciAm to avoid dealing with a union.
I didnβt know they saw SciAm as a liability bc they were losing federal subscribers over Trump coverage.
www.whatsitlike.me/the-story-sc...
The Rubin Observatory in Chile is an accidental art machine. It is gearing up to produce a 10-year, high-def movie of the whole universe. But along the way, it's returning beautiful images like this one of the Seagull Nebula in the constellation Monoceros. π§ͺπ
rubinobservatory.org/news/rubin-c...
Psyche!
NASA mission to a metal asteroid, possible fragment of a planetesimal core.
Now beyond Mars and on its way to the asteroid belt, arriving summer 2029! Was there for launch! Fair winds and following seas. π§ͺπ
www.jpl.nasa.gov/news/pedal-t...
Scientists have debated for decades whether the human brain sprouts new neurons throughout life. A feature in Nature asks what it would mean if our brains could grow new neurons and how much evidence is enough. #Neuroskyence π§ͺ
CSUN Biology seeks a "Bird or Mammal Biologist" studying extant, non-model birds or mammals, and having experience in collections management, to teach Avian Ecology and/or Mammalogy and help steward our natural history collections (showy examples pictured)
careers.pageuppeople.com/873/nr/en-us...
Unraveled 55 pro- and anti-HIV factors in CD4+ T cells using CRISPR screens. Key insights reveal diverse antiviral mechanisms. Game changer in HIV research! PMID:42013838, Cell 2026, @Cellhttps://www.cell.com/cell/fulltext/S009286742600382X#Medsky#Pharmsky#RNA#ASHG#ESHG π§ͺ
A paper in Nature describes the fossil of an early relative of mammals that shares some adaptions seen in the modern platypus, from the Jurassic period of China. The remains shed light on the evolutionary origins of suckling and swallowing. go.nature.com/4zpn0Nc#Paleosky π§ͺ
Indeed, years before Genealogy of Morals, Darwin had argued that our moral principles had evolved from social instincts.
I wrote about that here (paywall): https://muse.jhu.edu/article/676147/pdf
π±π #HistSTM#philsci#psychsky#evobio π§ͺ
Healthy corals can pass tiny symbiotic algae (dinoflagellates) to bleached corals through brief physical contact. Within weeks, this transfer can drive the bleached coral to full recovery! π§ͺ
www.science.org/doi/10.1126/...
Artificial light at night (ALAN) is a substantial, growing and largely unregulated threat to biodiversity worldwide. A Review in Nature Reviews Biodiversity examines the state of knowledge regarding the measurement, impacts and mitigation of ALAN. go.nature.com/4yglFr2 ππ§ͺ
BDSC is an incredible resource to the field and is behind so much important science. I didnβt realize it is only a couple years older than I am! π π§ͺ
40 years ago today, the BDSC made its 1st shipment. To celebrate, Trudy Kaufman, who packed the 1st shipment, boxed up the same kinds of flies for John Roote at Cambridge, who placed the 1st order. Watch for pics of the arrival next week. Weβve shipped 4,882,378 vials total. Thatβs a lot of flies!
"I spent the months of March, April, May & June last at No. 4161, Riva dei Schiavoni, where I had a little fourth floor, the view so divine (...) & the situation so convenient, that it was a very tolerable situation. I wrote there the larger part of my last novel."
- Henry James
Indeed they did.
This is an important change that will make biomedical science like cancer and dementia research worse, by allowing newly political roles (program officials now under Schedule F/P/C and IC directors chosen by politicals) free rein to choose projects to fund.
As a PhD student designing my first survey, I added what I thought was a throwaway question at the end. To my surprise, thousands of academics answered it! The paper is out today: doi.org/10.1093/pnas...
A Moscow court sentenced Russian ornithologist Sofya Rozenfeld to 3.5 years in a penal colony on 7 October over two small donations to an anticorruption organization proscribed by the Russian government. https://scim.ag/4jUFyQH
1/4 Our new preprint is out on bioRxiv: Arousal-informed neuronal avalanches operate near criticality.
We investigate whether neuronal activity in awake cortex operates near a critical point, and how this relates to sensory stimulation and arousal.
doi.org/10.64898/202...
π¨ New preprint
11,000+ human brain microvessels in cSVD.
Key findings:
β’ Early, bimodal pericyte loss
β’ Endothelial activation comes later
β’ Venous-like microvascular shift
β’ Capillary density β
π‘ Suggests a sequential vascular pathology, not parallel.
π www.biorxiv.org/content/10.6...
Glycosylation is among the most important modifications in biology.
We know relatively little about glycobiology, because it is hard to study.
This Nat Rev Methods primer describes our best tools for analyzing glycosylation π½