Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁

@eisch.bsky.social

Philadelphia Neuroscience Professor obsessed w/dentate gyrus, mentoring, unsweet soymilk. Opinions & bad jokes are mine not my employer’s. She/her/cat. https://sites.google.com/view/eischlab Pics: 75% my smiling face, desk, laptop, blue sky with clouds

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Want to chase memory engrams with us? Our NIMH-funded lab studies how LEC inputs shape dentate gyrus engrams. Seeking a postdoc (US work authorization required) to apply with me for CHOP's 3-yr SPAR Fellowship. Apply by Nov 20, earliest possible start July 2027. DM me 🧠πŸ§ͺ please RT!

research.chop.eduSupporting Promising Academic Researchers FellowshipThe Supporting Promising Academic Researchers Fellowship at Children's Hospital of Philadelphia partners with the University of Pennsylvania’s Provost Fellowship Program to fund Fellowship Programs at...

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

A paper in Nature Medicine presents a device platform that converses with patients to help them manage their epilepsy. In a small test, patient feedback helped the system improve seizure detection, cutting false alarms by about 80 percent. go.nature.com/489Oo5X #medsky πŸ§ͺ

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

How does the brain represent symbolic integers and fractions? This study shows that educated adults process both integers and fractions within a shared, topographic map, indicating that the brain integrates numerical concepts to compare magnitudes. πŸ§ͺ #NeuroSky #math #numerosity plos.io/4jveiIp

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

One of the very first video games, and certainly the first (but not last!) example of a video game designed by a physicist! πŸ§ͺ βš›οΈ πŸ‘Ύ

Physicist William Higinbotham was born #OTD in 1910. During the Manhattan Project he was the Electronics Group leader at Los Alamos. In 1958, while working at Brookhaven Lab, he invented one of the first video games: β€œTennis for Two.” It ran on an oscilloscope! πŸ§ͺ βš›οΈ Image: Brookhaven National Lab

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Billions of our hard earned tax dollars that were meant for science funding went unspent. The money will be spent on whatever Trump's priorities are, not basic research. Brought to you from party of waste, fraud of abuse. πŸ§ͺ cen.acs.org/policy/resea...

cen.acs.orgNSF closes fiscal 2026 with over $1 billion left unspentThe agency says the money will be invested in Trump-aligned initiatives

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Orexin agonists have been approved for the treatment of a type of narcolepsy. A feature in Nature reports on how they could also treat conditions across the health spectrum, much like what has happened with GLP-1 drugs. #medsky πŸ§ͺ

go.nature.comWill this sleep-disorder drug be the next big blockbuster?Orexin agonists have been approved for the treatment of a type of narcolepsy, yet they could also treat conditions across the health spectrum.

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

New study: Integrin-Ξ±8⁺ mesenchymal stem cells in the bone marrow play key roles in maintaining hematopoietic stem cell function. Depleting these cells decreases HSC numbers and activity. PMID:42409817, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75276-2 #Medsky #Pharmsky #RNA πŸ§ͺ

doi.orgEndosteal integrin-α8⁺ mesenchymal stem cells maintain haematopoietic stem cell function via extracellular matrix-mediated interactions | Nature CommunicationsThe stem cell niche is a specialised microenvironment essential for maintaining haematopoietic stem cells (HSCs). Here we identify a distinct subset of mesenchymal stem cells (MSCs) expressing integrin α8 (Itga8⁺ MSCs) within the bone marrow (BM) endosteum. These cells exhibit distinct MSC properties and higher haematopoietic supportive activity than other MSC subsets. Depletion of Itga8⁺ MSCs decreased HSC numbers, reduced quiescence of endosteal HSCs and diminished BM repopulating capacity. Itga8⁺ MSCs support haematopoiesis through cell adhesion-related mechanisms. Single-cell RNA sequencing further identified Itga8⁺ MSCs as a distinct subpopulation within bone-lining cells. Moreover, we identified Mfap4 as a candidate factor expressed in Itga8⁺ MSCs, and Mfap4 supported the BM reconstitution capacity of HSCs. These results suggest that Itga8⁺ MSCs represent a distinct niche cell population for HSC maintenance. This work provides new insights into HSC regulation and strategies to op

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

A 75,000-year-old Neanderthal from Shanidar Cave, Iraqi Kurdistan, shows evidence of a potentially lethal spear wound, offering rare insight into violence among our ancient relatives. The findings are published in Scientific Reports. πŸ§ͺ🏺

go.nature.comEvidence for funerary behaviour and lethal trauma in a new Neanderthal individual from Shanidar Cave - Scientific ReportsShanidar Cave has long featured in debates concerning Neanderthal cognitive capacity and behaviour, including evidence for care and intentional burial. By identifying additional individuals, including Shanidar A reported here, new excavations have expanded a burial cluster first identified in 1960. Shanidar A, an older adult, was deposited around 75,000 years ago, decayed, and their skeletal remains were subsequently disturbed by a flash flood. Our findings raise the minimum number of individuals in this unparalleled cluster to five, supporting interpretations of complex, potentially meaningful Neanderthal mortuary behaviour. Shanidar A also demonstrates major non-fatal trauma to the face and rare evidence of perimortem penetrating trauma among Neanderthals. Trauma among Middle and Upper Palaeolithic Neanderthals and modern humans, and subsequent survival, is common. However, the facial injury was severe and unusual. It suggests care from group members, the evolutionary origins of which are also contentious. The nature of the perimortem penetrating traumatic injury adds to a small corpus of such injuries in the hominin fossil record. The morphology of this scapula perforation is consistent with injury from a wooden spear, providing valuable (albeit indirect) evidence for the use of wooden implements in the Middle Palaeolithic, which is often difficult to demonstrate given the rare preservation of organic materials.

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Over 2,700 human mRNA 3' UTRs show conserved sequences that regulate proteins with long intrinsically disordered regions (IDRs). KDM6B 3' UTR alters JMJD3 folding, enhancing IDR interactions, thereby… PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky πŸ§ͺ

cell.comhttps://www.cell.com/cell/fulltext/S0092-8674(26)00576-3No description available

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Researchers analyzed 17 visual pigments in the mantis shrimp eye, discovering two red-light-absorbing proteins that can switch on and off using different wavelengths of light and that could potentially serve as molecular switches to modulate disease signaling pathways. https://bit.ly/4i0dZnN πŸ’‘ βš›οΈ πŸ§ͺ

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

πŸ§ͺA new study from our lab! Led by @luisaguirre.bsky.social: we analyzed 383 pollination, seed-dispersal & host–parasite networks worldwide. Climate mostly shapes network structure, but human impact hits bird- and insect-mediated networks hardest. πŸ“„ doi.org/10.1111/geb.70246 #Ecology #Biogeography

doi.orgThe Multifaceted Effects of Anthropogenic and Climatic Factors on Ecological NetworksAim Biotic interactions, such as pollination, seed dispersal, and parasitism, are key for biodiversity and ecosystem function. Ecological networks quantify the structure of biotic interactions, prov...

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

The night sky in Vincent van Gogh’s painting The Starry Night may have been inspired by a celestial arrangement visible before dawn on 22 July 1889, according to research in Scientific Reports. The authors argue that the conventional June dating of the work should potentially be reconsidered. πŸ”­πŸ§ͺ

go.nature.comThe actual sky of Van Gogh’s Starry Night: a multidisciplinary reconstruction - Scientific ReportsThe Starry Night: whether its sky represents spontaneous fantasy or a realist depiction has gone unanswered for over a century. Earlier astronomical readings, constrained by the conventional June dating, reached mutually exclusive conclusions, and the painting’s celestial arrangement was never quantitatively tested. In contrast, this study narrows the dates on which the Moon and Venus fall within the painter’s field of view, confirms that selection by Procrustes fitting of the asterism, and cross-checks it against meteorological and bioclimatic records and the original letters. The procedure is first applied to night paintings by Elsheimer and Millet, and validated on two 1888 night paintings whose sites survive. The painter’s narrow frame, recovered from an earlier sketch of the same terrain, is then applied to the 1889 sky. At dawn around 22 July 1889, the waning-crescent Moon, Venus, and the Hyades cluster gather within that narrow frame, while the asterism’s geometry, contemporary weather records, and the letters independently converge on the same date. These findings suggest that the night sky in The Starry Night originated from observation of a specific celestial arrangement, and call for reconsidering the June dating. This framework can extend to historical night paintings as a reproducible scientific art history.

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Replying to @whatsitlike.me

Here’s my piece of having SciAm kill an urgent story of mine after their acquisition. I knew Springer Nature likely sold SciAm to avoid dealing with a union. I didn’t know they saw SciAm as a liability bc they were losing federal subscribers over Trump coverage. www.whatsitlike.me/the-story-sc...

whatsitlike.meThe story Scientific American wouldn't let me tellWhen the media institution tumbled, I wasn't about to let my reporting go with it.

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

The Rubin Observatory in Chile is an accidental art machine. It is gearing up to produce a 10-year, high-def movie of the whole universe. But along the way, it's returning beautiful images like this one of the Seagull Nebula in the constellation Monoceros. πŸ§ͺπŸ”­ rubinobservatory.org/news/rubin-c...

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Scientists have debated for decades whether the human brain sprouts new neurons throughout life. A feature in Nature asks what it would mean if our brains could grow new neurons and how much evidence is enough. #Neuroskyence πŸ§ͺ

go.nature.comCan your brain grow new neurons? How researchers are solving a century-old puzzleScientists have debated for decades whether the human brain sprouts new neurons throughout life. What would it mean if it could β€” and how much evidence is enough?

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

πŸ‘©πŸ»β€πŸ”¬πŸ§ͺ

CSUN Biology seeks a "Bird or Mammal Biologist" studying extant, non-model birds or mammals, and having experience in collections management, to teach Avian Ecology and/or Mammalogy and help steward our natural history collections (showy examples pictured) careers.pageuppeople.com/873/nr/en-us...

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

T minus 6 days until our trip to visit these lovely beings 🌎πŸ§ͺπŸ¦‰πŸ¦‘ (Photo under permit AMLR 2025)

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

A paper in Nature describes the fossil of an early relative of mammals that shares some adaptions seen in the modern platypus, from the Jurassic period of China. The remains shed light on the evolutionary origins of suckling and swallowing. go.nature.com/4zpn0Nc #Paleosky πŸ§ͺ

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

And here (free): jhiblog.org/2017/11/13/w... πŸŒ±πŸ‹ #HistSTM #philsci #psychsky #evobio πŸ§ͺ

jhiblog.orgWhat if Humans Were Raised Like Bees? Charles Darwin and the Evolution of MoralityBy Greg Priest Read the full companion article in this quarter’s Journal of the History of Ideas. A new biography of Charles Darwin is coming out. Styled as a β€œradical reappraisal,” the book, by...
Greg Priest@gregpriest.bsky.social

Indeed, years before Genealogy of Morals, Darwin had argued that our moral principles had evolved from social instincts. I wrote about that here (paywall): https://muse.jhu.edu/article/676147/pdf πŸŒ±πŸ‹ #HistSTM #philsci #psychsky #evobio πŸ§ͺ

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Artificial light at night (ALAN) is a substantial, growing and largely unregulated threat to biodiversity worldwide. A Review in Nature Reviews Biodiversity examines the state of knowledge regarding the measurement, impacts and mitigation of ALAN. go.nature.com/4yglFr2 🌎πŸ§ͺ

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

BDSC is an incredible resource to the field and is behind so much important science. I didn’t realize it is only a couple years older than I am! πŸŽ‚ πŸ§ͺ

40 years ago today, the BDSC made its 1st shipment. To celebrate, Trudy Kaufman, who packed the 1st shipment, boxed up the same kinds of flies for John Roote at Cambridge, who placed the 1st order. Watch for pics of the arrival next week. We’ve shipped 4,882,378 vials total. That’s a lot of flies!

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

"I spent the months of March, April, May & June last at No. 4161, Riva dei Schiavoni, where I had a little fourth floor, the view so divine (...) & the situation so convenient, that it was a very tolerable situation. I wrote there the larger part of my last novel." - Henry James

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Indeed they did. This is an important change that will make biomedical science like cancer and dementia research worse, by allowing newly political roles (program officials now under Schedule F/P/C and IC directors chosen by politicals) free rein to choose projects to fund.

scientificamerican.comNIH appears to shut down comments on science peer-review rule change ahead of scheduleThe proposed change to how the National Institutes of Health handles grant applications has been criticized by scientists as reducing transparency

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Claude has suggested I go and eke out an existence in a windswept and desolate lighthouse

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

As a PhD student designing my first survey, I added what I thought was a throwaway question at the end. To my surprise, thousands of academics answered it! The paper is out today: doi.org/10.1093/pnas...

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

A Moscow court sentenced Russian ornithologist Sofya Rozenfeld to 3.5 years in a penal colony on 7 October over two small donations to an anticorruption organization proscribed by the Russian government. https://scim.ag/4jUFyQH

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

1/4 Our new preprint is out on bioRxiv: Arousal-informed neuronal avalanches operate near criticality. We investigate whether neuronal activity in awake cortex operates near a critical point, and how this relates to sensory stimulation and arousal. doi.org/10.64898/202...

doi.orgdoi.org

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Publication alert πŸ€“πŸŽ‰ Well done Audrey, Dany, and Conor πŸ™Œ link.springer.com/article/10.1...

link.springer.comPericyte loss and endothelial activation define distinct vascular states in cerebral small vessel disease - Acta NeuropathologicaCerebral small vessel disease (cSVD) is a leading cause of stroke and vascular cognitive impairment, yet the cellular mechanisms underlying microvascular dysfunction in human disease remain incomplete...
Axel Montagne@axelmontagne.bsky.social

🚨 New preprint 11,000+ human brain microvessels in cSVD. Key findings: β€’ Early, bimodal pericyte loss β€’ Endothelial activation comes later β€’ Venous-like microvascular shift β€’ Capillary density ↑ πŸ’‘ Suggests a sequential vascular pathology, not parallel. πŸ”— www.biorxiv.org/content/10.6...

Amelia Eisch πŸ§ͺπŸ§ πŸ‘©β€πŸ”¬ 🐁 reposted

Glycosylation is among the most important modifications in biology. We know relatively little about glycobiology, because it is hard to study. This Nat Rev Methods primer describes our best tools for analyzing glycosylation πŸ”½