Ellen Foxman

Ellen Foxman

@ellenfoxman.bsky.social

Associate Professor, Immunologist, Physician-Scientist. Studying human immunology, innate immunity, host-virus interactions for better diagnosis, treatment, prevention. Opinions are my own.

2.6K followers1K following47 posts

Ellen Foxman
@ellenfoxman.bsky.social

Excited to see this beautiful image of nasal #organoids featured as biomedical Image of the day by @cellpress.bsky.social 🙏🙏🙏 See full paper @cellpressblue.bsky.social #respiratory #lungs #EpithelialMechanics #IdSky #MedSky #ImmunoSky

Biomedical Picture of the Day BPoD@bpodaily.bsky.social

Response to rhinovirus depends on levels of interferon production & viral load – differences revealed using a nasal organoid 📷 Julien Amat & Bao Wang, relating to B.Wang et al article @yaleschoolofmed.bsky.social in @cellpressblue.bsky.social ➡️ bpod.org.uk/archive/2026... with @rooph.bsky.social

Ellen Foxman
@ellenfoxman.bsky.social

#Epithelialmechanics fans...interferons protect against viruses but also impair recovery post-infection. In new work @plosbiology.org we show that interferons block epithelial repair by co-opting the Hippo pathway #innateimmunity #lungs #respiratory journals.plos.org/plosbiology/...

journals.plos.orgDose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cellsInterferons (IFNs) initiate antiviral defence when infected cells sense a virus protecting against infection via JAK/STAT signaling, but can hinder recovery by impairing tissue repair by an unknown me...

Ellen Foxman reposted

Thelonevirologist
@thelonevirologist.bsky.social

Frequent presymptomatic household transmission of influenza A but not influenza B virus www.nature.com/articles/s44...

nature.comFrequent presymptomatic household transmission of influenza A but not influenza B virus - Nature HealthBased on two waves of data collection from 748 households in Hong Kong, this analysis sheds light on the number of transmission events that occurred before manifestation of symptoms in influenza A and...

Ellen Foxman reposted

Ivan Zanoni
@lozanzi.bsky.social

#InterferonFriendsOrFoes? Another cool one @ellenfoxman.bsky.social &friends out @plosbiology.org about how excessive #IFNs delay repair by activating LATS & degrading YAP/TAZ in the Hippo 🦛 pathway! journals.plos.org/plosbiology/... 👇👇👇

journals.plos.orgDose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cellsInterferons (IFNs) initiate antiviral defence when infected cells sense a virus protecting against infection via JAK/STAT signaling, but can hinder recovery by impairing tissue repair by an unknown me...
PLOS Biology@plosbiology.org

#Interferons protect against #ViralInfection, but can hinder tissue repair - how? @ellenfoxman.bsky.social &co show that high IFN levels suppress #BronchialCell migration & proliferation during tissue repair via JAK-driven LATS1 activation, independent of STAT1 @plosbiology.org 🧪 plos.io/4k1pyKA

Ellen Foxman reposted

Ivan Zanoni
@lozanzi.bsky.social

Fantastic work @ellenfoxman.bsky.social &co! If you block the #InterferonPower, Rhinovirus activates NFkB & NLRP1 #inflammasome leading to IL1b secretion & excessive mucus production!

Ellen Foxman@ellenfoxman.bsky.social

Rhinoviruses cause common cold & asthma attacks but are also often benign. Using nasal organoids, we learned how the community of cells in the lining the nasal passages coordinates to respond to rhinovirus and which responses lead to excess mucus & inflammation. www.cell.com/cell-press-b...

cell.comRhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signalingRhinoviruses are the most frequent cause of common colds and also a major cause of respiratory distress in high-risk groups. Using single-cell sequencing of rhinovirus-infected nasal epithelial organo...
Ellen Foxman
@ellenfoxman.bsky.social

Rhinoviruses cause common cold & asthma attacks but are also often benign. Using nasal organoids, we learned how the community of cells in the lining the nasal passages coordinates to respond to rhinovirus and which responses lead to excess mucus & inflammation. www.cell.com/cell-press-b...

cell.comRhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signalingRhinoviruses are the most frequent cause of common colds and also a major cause of respiratory distress in high-risk groups. Using single-cell sequencing of rhinovirus-infected nasal epithelial organo...
Ellen Foxman
@ellenfoxman.bsky.social

Happy to share this review just out in Current Opinion in Immunology on innate immunity in the respiratory tract - also check out the other reviews in this collection on Intrinsic Immunity edited by John MacMicking #ImmunoSky #IDSky #pulmsky #MedSky www.sciencedirect.com/science/arti...

sciencedirect.comLayers of defense: protection from respiratory viruses by epithelial-intrinsic immunityA central challenge in defending mucosal barriers is protecting against pathogens while also limiting excessive inflammation. Respiratory viruses are …
Ellen Foxman
@ellenfoxman.bsky.social

#COVID19 revealed the urgent need for better ways to screen for & rule out respiratory virus infection. We present a nasal biomarker screening strategy to prevent & manage outbreaks @eBiomedicine.bsky.social #IDSky #MedSky #lungs @yaleschoolofmed.bsky.social www.thelancet.com/journals/ebi...

thelancet.comNasal biomarker testing to rule out viral respiratory infection and triage samples: a test performance studyThese results demonstrate the utility of a nasopharyngeal biomarker to rule out respiratory infection, with potential applications in outbreak management and/or routine screening in high-risk settings...

Ellen Foxman reposted

Hensley Lab
@scottehensley.bsky.social

Check out this news story that @nature.com wrote describing our recent preprint where we tested our H5 mRNA vaccine in calves. The data look good and we are currently testing the vaccine in lactating cattle...more to come!

Nature@nature.com

As bird flu sweeps across US poultry and cattle farms, researchers are racing to find ways to contain the outbreaks before they ignite a human pandemic. Now, a team of scientists has developed a fresh approach: the first mRNA bird-flu vaccine for cattle. https://go.nature.com/4kbOvTe

go.nature.comBird flu vaccine for cattle aces early testVaccines for livestock could reduce the risk of human outbreaks, but hurdles remain.

Ellen Foxman reposted

Thiago Carvalho
@cyrilpedia.bsky.social

'Neutrophils expressed notably low levels of STING, whereas forced expression led to uncontrolled systemic inflammation. During development in the thymus, Tcells dynamically & epigenetically restricted STING expression through DNMT1–mediated transcriptional silencing' #Immunology

science.orgDynamic STING repression orchestrates immune cell development and functionRepression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.

Ellen Foxman reposted

Sam Wang
@samwang.bsky.social

Today I'm filled with admiration for my university's president, Chris Eisgruber. He's standing up for Columbia and for universities as a home for freedom of ideas, debate, and thought - free of government attack. www.theatlantic.com/ideas/archiv...

theatlantic.comThe Cost of the Government’s Attack on ColumbiaAmerican universities have given the country prosperity and security. The Trump administration’s attack on academic freedom endangers all of that.

Ellen Foxman reposted

Kalev Freeman
@uvmtraumalab.bsky.social

My privilege to team up with FASEB President-elect Eric Kelley today. We visited the W. Virginia and #Vermont offices together to explain how science research saves lives, creates jobs and keeps the USA competitive. #FASEBonTheHill #FundScience #NIH #MedSky #AcademicSky #UVMLarnerMed🧪

Ellen Foxman reposted

Nicole Bedera
@nbedera.bsky.social

If there's one thing that domestic violence research has taught me, it's that abusers set up no-win scenarios. They punish you whether you cooperate with them or whether you push back. The only way out is to strengthen ties with people outside of the relationship who can create new, better options.

Ellen Foxman reposted

Vaughn Smider, MD, PhD
@vvsmider.bsky.social

Replying to @pamherd.bsky.social

I’m a biomedical researcher who lost his wife to cancer. Finding cures is personal to me. What’s happening at the NIH is devastating. Here’s my editorial in my hometown newspaper. www.vindy.com/opinion/edit...

vindy.comDOGE ends America’s golden age of biomedical researchBiomedical research impacts all of us. I became curious about how drugs work after my mom was diagnosed with rheumatoid arthritis when I was a small boy. She received “gold shots” as treatment, which ...

Ellen Foxman reposted

Ivan Zanoni
@lozanzi.bsky.social

#WeekendRead! #InflammasomePower! @rauchlab.bsky.social &co show @jem.org that small intestinal tufts cells activate the NLRC4 inflammasome leading to PGD2-dependent IL-22 production by ILC3, protecting against Salmonella! rupress.org/jem/article/...

rupress.orgEnteric tuft cell inflammasome activation drives NKp46+ILC3 IL22 via PGD2 and inhibits SalmonellaPGD2 released after NAIP-NLRC4 inflammasome activation in tuft cells signals onto ILC3s and mediates host defense mechanisms against Salmonella Typhimurium

Ellen Foxman reposted

Gabriele Pollara
@gpollara.bsky.social

Looking for a research assistant post in London? 🤔 Interested in how anti-cytokine auto-antibodies are associated with immune dysfunction and disease during ageing? 🎯 Then do consider applying for this exciting post 👇 #ImmunoSky #IDSky @uclmedsci.bsky.social www.ucl.ac.uk/work-at-ucl/...

ucl.ac.ukUCL – University College LondonUCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Ellen Foxman reposted

Dave Baltrus 🦦
@surtlab.bsky.social

In my 25 years since high school I’ve seen 1. HIV/AIDS go from death sentence to manageable with drugs 2. Cystic fibrosis go from pretty much an extended death sentence to manageable with drugs 3. Sickle cell go from a horrible disease to (almost maybe) cured by gene therapy Simply incredible

Ellen Foxman reposted

Hensley Lab
@scottehensley.bsky.social

Today @natmedicine.bsky.social published our study showing the older individuals born prior to 1968 have more antibodies that cross-react to #H5N1 relative to younger individuals. If H5N1 causes a pandemic, children will likely be the most susceptible. 1/2 www.nature.com/articles/s41...

nature.comImmune history shapes human antibody responses to H5N1 influenza viruses - Nature MedicineH5N1 strain-specific antibodies are higher in older individuals and correlate more with birth year than with age, suggesting that younger individuals are potentially more likely to benefit from H5N1 v...