Fabian Fröhlich

Decoding & manipulating human intercellular signaling via scalable cell-free protein synthesis https://www.biorxiv.org/content/10.64898/2026.10.24.761585v1

We Await Silent Tristero's Empire www.lesswrong.com/posts/WHEQps...

Pinal, make me a protein that makes me a sandwich.

Next week we will do a hackathon on AI coding agents in bioinformatics, joined virtually by 3 groups @colmr.bsky.social @emanuelvgo.bsky.social @dessimoz.bsky.social on protein structure, evolution, genetics, and cancer. We will post results throughout the week in case anyone wants to follow along

Our work out today in @nature.com! We identified a previously unknown function for WEE1 in cell cycle control that could explain some of the inhibitor side-effects. We found WEE1 inhibits APC/C(Cdh1) to promote S-phase and cell cycle entry. Inhibit Wee1 , block or impair cell cycle entry.

How we are approaching AI at openRxiv - new blog post prompted by growing adoption by researchers, submission patterns, and questions from the community openrxiv.org/approach-to-... 1/n

🚨New preprint! Ligands at the same GPCR can produce wildly different signaling outputs. Why? We built a mutational scanning platform to measure ~10,000 µOR variants across 15 opioids, yielding ~400k measurements of how sequence and ligand chemistry set signaling. www.biorxiv.org/content/10.6... 1/10

Can we design proteins that cut other proteins? Our de novo cysteine protease paper is out in Nature! We designed new folds that cleave peptide backbones, with activity demonstrated in mammalian cells. Paper and code 👇 www.nature.com/articles/s41...

www.anthropic.com/research/emp... On the note of railroads giving us the managerial corporation, it of course also gave us other silly ideas like the Bering Strait crossing en.wikipedia.org/wiki/Bering_...

It‘s been two years since the pre-print. In the meantime, we have been busy validating ConvexGating based gating strategies in the lab. Check out our publication at Nat Comm: www.nature.com/articles/s41...

I got really excited about the paper and then it just ended 🫠

It saved some for you. (One shot!)

Good old Satanists www.404media.co/it-is-done-h...

German lesson for today: „Dampflaberer" — someone whose AI hot takes are as intellectually lazy as the slop they're criticising. Some concerns are real and deserve better than recycled talking points. Running their Gschmarri past an AI assistant might help.

I came across this parody of a rumored upcoming press release by OpenAI: "OpenAI Releases the Final Ten Minutes of 500 Previously Unreleased Films, Ushering in a New Era of Movie Watching" : x.com/Endings500/s...

So a few folks asking why OAI is releasing this at all. And I think that's probably worth a thread in its own right

As habitual AI user for writing who regularly sees "100% human" scores on text with 80%+ LLM-written words, I suspect that: (i) reliability of AI detection is overestimated, (ii) writing of latest-gen models is under-appreciated, and (iii) "LLM-generated" is not as clear cut as many people think

AI & biomed research. @charlesswanton.bsky.social & I write for the @standard.co.uk.web.brid.gy about how AI can help us in @crick.ac.uk to understand how life works: what keeps us healthy, what sets disease in motion & why patients respond differently www.standard.co.uk/news/tech/ai...

Looking for a PhD? @crick.ac.uk PhD applications for next year are open. 4 year program with lots of outstanding projects on offer. If you are interested in viral host interactions, cytoskeleton, cell bio, live cell imaging - see Way lab project + video. plz repost www.crick.ac.uk/careers-and-...

Applications are open for @crick.ac.uk PhD student program. This is an outstanding 4 year program run by an incredible team that puts students at the heart of everything they do. Lots of great projects to choose. We have 2 positions in our lab this year! Please apply! www.crick.ac.uk/careers-and-...

Our AI for Biological Discovery online seminar series continues with “Communities of AI agents for scientific discoveries” by James Zou, Stanford University, on 7 October at 15:00 BST. Register now for the webinar: www.eventbrite.co.uk/e/ai-in-biol...

Applications are open for our new AI/ML clinical fellowships, combining formal MSc-level training in AI and machine learning with PhD or postdoctoral research at the Crick. Find out more about the programme and apply by 11 November: https://bit.ly/4hxmAgn

Mechanistic World Models for biology are (almost) here: www.biorxiv.org/content/10.6...

"What are we even trying to do here?" Is what I have been asking many people in academia more widely lately. It is long past time for us, across *all* fields, to rethink the faux-meritocracy of numerical metrics (# of papers, citations, etc). We really should decide and reward what we truly value.

PhD opportunity in our lab at @ucl.ac.uk! 🧬 How do colorectal tumours spatially adapt to treatment? Study cancer cell plasticity using organoids, single-cell, & spatial biology. 4 years | Jan 2027 (flexible) | Stipend + UK home fees ucl.ac.uk/work-at-ucl/... Please share!

Discover the latest issue of The Crick magazine, featuring stories on cancer, antimicrobial resistance, life after a Nobel Prize, liver health, heat and the human body, and more from across the Crick. Read now: https://www.crick.ac.uk/news-and-features/the-crick-magazine-issue-3

"All corners of academia will soon be flooded with AI-generated research....Maths and CS go first because their entire output is symbol manipulation...Biology comes later not because biologists are cleverer but because the rate-limiting step is physical" giorgio.gilest.ro/the-weimar-o...

The general attitude of our community towards a technology that can [...] suggests that these operationalizations of our values are at best incomplete.

A group of 25 Fields Medalists, including myself, have made a joint declaration on Math and AI: mathandai.org . We welcome additional signatories. See also this article in the Economist announcing the declaration: www.economist.com/science-and-...

I'm really excited to be heading to the Crick to start the Quantitative Spatial Biology lab! We'll be doing all things #spatialbiology, mathematical modelling, and AI, to get a deep understanding of the biological mechanisms underlying how spatial structures form in health and disease #newPI 🔬🧬🧪🧮

The new AC-DC paper is out! ⚡ One small gene circuit, more than 30 distinct dynamical behaviours. Showing how small regulatory networks can hide a surprising amount of dynamical complexity. www.cell.com/cell-systems...

openai.com/index/resear...

Maybe it’s time to say goodbye to UMAP and other low-dimensional embeddings (at least in many single-cell analyses). We developed MILK to encode single-cell populations into tree representations at unprecedented scales. www.biorxiv.org/content/10.6... Here’s what MILK is: 🧵

A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability www.nature.com/articles/s41...

🧬 One cell whispers code 🔗 neural nets meet ODEs 🔬 come decode with us

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

Join us for our first online AI for Biological Discovery Seminar, where our Chief AI Scientist Mihaela van der Schaar will host Caroline Uhler to discuss her research at the intersection of machine learning, statistics and genomics. Learn more and book your free ticket: https://bit.ly/4xAvNLL

I enjoyed this. ordinaryabundance.com

Curriculum learning is good, curriculum multiple shooting is better: new preprint on how to train ODE (including UDE and NODE) models: arxiv.org/abs/2608.05777

Yesterday I gave a talk at an OpenAI summit on the future of mathematics. I was asked to talk about the bad future, where humans become mathematically disempowered. Here's a blog post based on the talk: www.daniellitt.com/blog/2026/8/...

Many don't see how much AI has changed recently. Coding agents aren't just chatbots. We can’t deal with the challenges of AI if we don’t understand it. Here's a post to provide some evidence (Claude doing small ML experiments) and form intuitions. davidpreichert.substack.com/p/if-you-hav... 🧵..

ANNOUNCEMENT: All our sundials will be out of order this evening between about 6pm and 8pm, we apologise for any inconvenience this may cause. Normal service will resume tomorrow. In unrelated news, enjoy the eclipse later... Photos: Mike Selby, Annapurna Mellor, Chris Davies, John Millar

1/ New preprint! with @solersanchisx.bsky.social @cwjpugh.bsky.social @federicobilleci.bsky.social @jonnyfrazer.bsky.social and Mafalda Dias, we introduce a scalable framework to improve stability prediction and separate folding from functional constraints. www.biorxiv.org/content/10.6...