Shefali

Shefali

@iamshef.bsky.social

Seeking postdoc positions | PhD candidate | AHA Predoc Fellow | Studying metabolism and development in the Tennessen Lab at IU Bloomington | She is into dancing and Drosophila 💃🏽🎶🎙️👩🏽‍🔬🔬

1.1K followers1.5K following1K posts

Extended family members visited my parents and said some mean things about how raising an only daughter to be "too educated" is not a good idea. Jesus Christ we are living in the 21st fucking century 🤷🏽‍♀️

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FlyBase: Development and metamorphosis into the Alliance. Marygold SJ, Attrill H, Dos Santos G, Gramates LS, McLachlan A, Millburn G, Tabone CJ, Zaru R; FlyBase Consortium. Genetics. 2026 Oct 26:iyag247. doi: 10.1093/genetics/iyag247. PMID: 42932930

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Are plant roots really made up of concentric layers of homogeneous, differentiating cell types? In our new study, out now in @nature.com, we show a more complex picture: two distinct cell states within root lineages, shaped in part by the environment. 🧵👇 www.nature.com/articles/s41...

nature.comAn environmentally regulated dichotomy in cell lineages of the root - NatureAn environment-regulated state is identified across multiple cell types at the root tip, revealing a shared dichotomy between cells with and without this state.

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📢 EASTBIO funded #PhD opportunity in our lab at #Edinburgh! Interested in #LiveImaging and capturing fascinating tissue dynamics in vivo through movies like this one? Get in touch to discuss further! Deadline: 16 Nov 2026 Please do share! www.findaphd.com/phds/project... #Drosophila #CellBio #DevBio

Not me liking pujo reels from everywhere on my Instagram and not doing anything productive for the entire evening 🤷🏽‍♀️💃🏽🙈

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Interested in speciation and from the UK? Apply for this PhD studentship to study speciation in snapdragons at UCL, supervised by Sean Stankowski and co-supervised by me! 👉 lnkd.in/eUBZBR-e Fieldwork in Spain, visits to Austria and much fun and flexibility to design your own projects guaranteed.

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honored to receive the community engagement award this year 😊 we made an onboarding handbook for *ALL* postdocs at Cornell, and we organize monthly professional development workshops for postdocs across departments - truly a team effort!! news.cornell.edu/stories/2026...

news.cornell.eduAchievement awards honor postdoctoral researchers and faculty mentors | Cornell ChroniclePostdoc Achievement Awards recognize postdocs who made outstanding contributions to the Cornell community, as well as faculty who provided exceptional mentorship to postdocs.

You wake up early to put in citations in the paper but then the number captchas, traffic lights and cars you have to select to prove that you're human is insane.

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Don't miss our session "Lessons learned: choosing mentors at different career stages" at #SACNAS2026! 📅 Sat, Oct 31 ⏰ 10:30 AM PDT 📍 Room 104 C, Level 2 Hear from a great lineup of speakers as we dive into mentorship strategies for every career stage. See you there! 🙌 @sacnas.bsky.social

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📢 TALK ALERT: Montreal peeps! I will be giving a talk in Montreal at Hôpital Maisonneuve-Rosemont Centre de Recherche on Oct. 23 (12 to 1 pm) on on our work identifying ancient functions of two tumour suppressors: promyelocytic leukemia (PML) protein and pre-mRNA processing factor 4 kinase (PRP4K).

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How does embryonic patterning remain robust when temperature changes the pace of development? In medaka, morphogen gradients rescale with developmental speed, despite morphogen diffusion remaining unchanged. Simulations point to a reaction-dominated mechanism. 👉 doi.org/10.64898/202...

doi.orgTemperature scaling of developmental tempo reveals reaction-dominated morphogen patterningA central question in developmental biology is how embryonic patterning remains robust when developmental tempo changes. In ectotherms, temperature strongly alters developmental speed and biochemical reaction rates, whereas diffusion is expected to change only weakly. How morphogen gradients required for patterning remain correctly scaled under these conditions is unclear. We addressed this problem in medaka embryos by quantifying developmental speed, morphogen clearance, diffusion, and endogenous Nodal dynamics across a broad temperature range. Developmental tempo, morphogen production, clearance, and tissue movement increased approximately two- to threefold per 10°C, whereas effective morphogen diffusion remained largely unchanged. Despite this mismatch, germ-layer proportions and morphogen patterning remained robust. Our mathematical simulations suggest that this robustness arises because the system operates in a reaction-dominated regime, in which changes in reaction and growth kinetics - rather than diffusion - are sufficient to rescale morphogen gradients. Together, our experiments and simulations provide new insights into how morphogen gradients adjust to maintain accurate tissue patterning across changes in developmental time and tempo. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, https://ror.org/0472cxd90, 637840, 863952 Deutsche Forschungsgemeinschaft, EXC 2117 – 422037984, SFB1756 – 550938463 FWF Austrian Science Fund, J 4507-B

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How does an embryo build itself? Join experimentalists and theorists as they discuss the principles of biological forms, from molecular mechanisms to whole organisms #EESDevelopment

EMBL Events@events.embl.org

Are you interested in developmental biology? Then we have news for you: #EESDevelopment is coming to EMBL next year which will explore how emerging technologies and transformative concepts are reshaping the field. 🧪 Submit your abstract by 2 March: s.embl.org/ees27-02-bl

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i am currently there at the #Purdue marker. If you're in West Lafayette, come see my talk for the Biology dept tomorrow Monday, 11:30!

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🧠🪰 Excited to share our paper in @elife.bsky.social detailing the synaptic connectome of the neurosecretory network in Drosophila. We mapped the hormone-releasing neurosecretory cells (NSCs) in the fly brain and their connectivity. 🧵https://doi.org/10.7554/eLife.102684

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The final version of our paper on Drosophila brain endocrine cells is out now in eLife. elifesciences.org/articles/102... Check out the thread from the first author @tmckim.bsky.social here for more details: bsky.app/profile/tmck...

Theresa McKim@tmckim.bsky.social

🧠🪰 Excited to share our paper in @elife.bsky.social detailing the synaptic connectome of the neurosecretory network in Drosophila. We mapped the hormone-releasing neurosecretory cells (NSCs) in the fly brain and their connectivity. 🧵https://doi.org/10.7554/eLife.102684

Pujo greetings everyone ! May we all continue to grow, learn, reflect and enrich ! It's that time of the year when I miss home the most - even being so far away from home, I can almost smell pujo. 🥁🎺🪇🔔🐚🏠 #pujo

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@joethorntonlab.bsky.social and I are thrilled to co-organize the 2027 Molecular Mechanisms in Evolution GRC, June 13–18, in beautiful Portland, Maine! See our ⭐stellar⭐ lineup of speakers ⬇️ spanning evolutionary biochemistry, cell biology, development, behavior... www.grc.org/molecular-me... 1/n

grc.org2027 Molecular Mechanisms in Evolution Conference GRCThe 2027 Gordon Research Conference on Molecular Mechanisms in Evolution will be held in Portland, Maine. Apply today to reserve your spot.

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This is how to support science! I’ve always been a bit jealous of folks who casually mention “so we got the allele from Bloomington” I wonder how many discoveries from almost 5 million shipments. Congrats!

40 years ago today, the BDSC made its 1st shipment. To celebrate, Trudy Kaufman, who packed the 1st shipment, boxed up the same kinds of flies for John Roote at Cambridge, who placed the 1st order. Watch for pics of the arrival next week. We’ve shipped 4,882,378 vials total. That’s a lot of flies!

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4 decades of stocks sent out by the @bdsc.bsky.social, nearly 5M vials!! countless crosses, experiments and knowledge generated from those flies. fun fact, like having a low area code is a cachet (eg 212), low digit BUN (Bloomington user number) IDs are a status symbol for some. my old lab was #40.🪰

40 years ago today, the BDSC made its 1st shipment. To celebrate, Trudy Kaufman, who packed the 1st shipment, boxed up the same kinds of flies for John Roote at Cambridge, who placed the 1st order. Watch for pics of the arrival next week. We’ve shipped 4,882,378 vials total. That’s a lot of flies!

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Interested in aging research? We're hiring a Research Technician to help manage our fly lab at Tufts HNRCA in Boston. Responsibilities include managing fly stocks, supervising undergraduates, and supporting studies of behavior, genetics, and healthy aging. Apply here: jobs.tufts.edu/jobs/23747?l...

jobs.tufts.eduResearch Technician, Metabolism and Basic Biology of Aging in Boston, Massachusetts | Tufts UniversityTufts University is hiring a Research Technician, Metabolism and Basic Biology of Aging in Boston, Massachusetts. Review all of the job details and apply today!