Joshua G. Schraiber

Joshua G. Schraiber

@jgschraiber.bsky.social

Evolutionary biologist, computational biologist, statistician. I like to develop mathematical models of evolutionary process and see how they fit to data. I also like cities where building apartments is legal and greatly dislike fascism

3K followers2.7K following7.3K posts

Joshua G. Schraiber reposted

Tariffs between Canada and the US have now been normalized. It’s just a matter of their levels. No one is talking about the USMCA and its renewal anymore. If Canada ends up making a deal that includes tariffs, then Trump’s coercive approach will have won the day.

Joshua G. Schraiber reposted

I a just old enough to remember what the aftermath of 9/11 was like, and even then a member of the Bush administration saying something this Islamophobic would have been unthinkable. Sure they still thought these things but getting rid of the norms that kept them from saying it has been awful.

The Bulwark@thebulwark.com

RFK: "There's five hundred million Arabs in the world. And yet they don't produce science. They don't win the Nobel Prize. They don't win the Fields Prize. They don't win the Wolf Prize. They don't produce literature."

Joshua G. Schraiber reposted

Replying to @alonlevy.bsky.social

So then to rephrase, Wiles had a reasonable belief that he wouldn't get beaten to the punch if he prevented being scooped. Now it seems likely many of the prestige problems are gonna be knocked out as a side effect of O.AI trying to find interesting things to test their models against.

These guys are just literal racists and that's their number one most important motivation

The Bulwark@thebulwark.com

RFK: "There's five hundred million Arabs in the world. And yet they don't produce science. They don't win the Nobel Prize. They don't win the Fields Prize. They don't win the Wolf Prize. They don't produce literature."

Joshua G. Schraiber reposted

Replying to @pekka.bsky.social

Gemini thinks this existence proof "represents at least half of the total journey" towards the Yang–Mills existence and mass gap Millennium Problem.

Joshua G. Schraiber reposted

i don't think anyone should run explicitly on banning online gambling but i do think that a democratic-led government should just quietly take steps to undermine the industry and create an inhospitable regulatory environment

David Brauer@dbrauer.net

Lula won in part by banning online gambling

Joshua G. Schraiber reposted

Replying to @jamellebouie.net

Mutually incompatible regulatory regimes. CA should require something NY prohibits. Make their compliance departments balloon.

Joshua G. Schraiber reposted

Replying to @jdcmedlock.bsky.social

Meanwhile, one of the most harmful policy movements in America right now is a property tax revolt that is shifting us away from our most economically efficient tax, all so property owners can have a little more in their pockets next month.

Joshua G. Schraiber reposted

Hey!! It's one thing to go mucking around in fluid dynamics, but this feels personal. A lot of problems I care about have hardness results conditioned on ETH. This will invalidate a lot of results.

Joshua G. Schraiber reposted

Joshua G. Schraiber reposted

Joshua G. Schraiber reposted

From Auckland to Vancouver, inner-ring neighborhoods are reserved for the rich to have low-density housing next to the downtown job center. This is regressive and inefficient, creating sprawl and forcing everyone else into long commutes.

Joshua G. Schraiber reposted

Replying to @jamellebouie.net

candidate quality matters a lot in senate elections and there's a bunch of GOP candidates in deep red areas who have never had to run in a competitive election before, south carolina definitely included

If you ever thought "percent of income spent on housing" was a useful metric of housing affordability, I introduce you to this plot where San Francisco is at the bottom.

David H. Montgomery@dhmontgomery.com

Median rent as a share of median income of renter households in major U.S. metros, 2010 vs. 2024. Minneapolis is lowest on the list, at 29%, down from 30.4% in 2010. www.artio.so/dataviz/page...

Joshua G. Schraiber reposted

Replying to @kevinerdmann.bsky.social

Yeah - definitely not arguing that the housing market is fine - just that "% of consumption spent on housing" is a really bad metric for evaluating it, for good or bad.

Joshua G. Schraiber reposted

Replying to @besttrousers.bsky.social

ie, you have a two earner household paying 30% of their income in rent. Then one of them loses their job (but gets 50% of it in UI payments). Now they are pay 40% of their income (including UI) in rent until the second earner finds a new job.

Joshua G. Schraiber reposted

Replying to @besttrousers.bsky.social

The reason "percent of income spent on housing" is slightly lower in 2024 than 2010 isn't because housing is more affordable today. It's because in 2010 there were a bunch of households that had two earners in 2007 trying to stay in their house with one earner in 2010.

Joshua G. Schraiber reposted

doi.orgFrequency-dependent fitness effects are ubiquitous in rapidly adapting microbial populationsIn simple microbial populations, the fitness effects of selected mutations are typically assumed to be constant, regardless of mutant frequency. This assumption underpins predictions about evolutionar...
Joao Ascensao@joaoascensao.bsky.social

How common are frequency dependent fitness effects? New preprint out today 👇 doi.org/10.1101/2025...

doi.orgFrequency-dependent fitness effects are ubiquitousIn simple microbial populations, the fitness effects of most selected mutations are generally taken to be constant, independent of genotype frequency. This assumption underpins predictions about evolutionary dynamics, epistatic interactions, and the maintenance of genetic diversity in populations. Here, we systematically test this assumption using beneficial mutations from early generations of the Escherichia coli Long-Term Evolution Experiment (LTEE). Using flow cytometry-based competition assays, we find that frequency-dependent fitness effects are the norm rather than the exception, occurring in approximately 80\% of strain pairs tested. Most competitions exhibit negative frequency-dependence, where fitness advantages decline as mutant frequency increases. Furthermore, we demonstrate that the strength of frequency-dependence is predictable from invasion fitness measurements, with invasion fitness explaining approximately half of the biological variation in frequency-dependent slopes. Additionally, we observe violations of fitness transitivity in several strain combinations, indicating that competitive relationships cannot always be predicted from fitness relative to a single reference strain alone. Through high-resolution measurements of within-growth cycle dynamics, we show that simple resource competition explains a substantial portion of the frequency-dependence: when faster-growing genotypes dominate populations, they deplete shared resources more rapidly, reducing the time available for fitness differences to accumulate. Our results demonstrate that even in a simple model system designed to minimize ecological complexity, subtle ecological interactions between closely related genotypes create frequency-dependent selection that can fundamentally alter evolutionary dynamics. ### Competing Interest Statement The authors have declared no competing interest.

Joshua G. Schraiber reposted

yeah like i was meeming last night but "turbo-corrupt guy in his 80s that cost control of parliament to the bolsonarists and only won the presidency 52-48" is not a recipe for long-term electoral good happen or short-term good governance

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Joshua G. Schraiber reposted

Public offerings that give one person & their heirs perpetual free rein over a company — able to mismanage to the tune of billions at a time, with impunity — need to be significantly restricted, if not regulated from existence.

The Washington Post@washingtonpost.com

A recent securities filing spotlighted what triggered Mark Zuckerberg’s months-long power battle with board directors at Meta — a fight that sparked not-so-veiled threats from Zuckerberg and led board members to contemplate quitting.

Joshua G. Schraiber reposted

Replying to @sky.skymarchini.net

agree with george [full disclosure: I'm not an equities guy] and i'd add that liabilities are WAY less than i was expecting and their off-balance-sheet arrangement (incl. contracted compute) looks reasonable, this is a barnbuster of a prospectus tbh

The unit economics here are frankly shocking they're so good. This is wildly stronger than I expected tbh.

This sucks?

Pitch Mr. Perfect@michaelwaterloo.bsky.social

I can confirm ESPN's report. Game 6 of the #WNBA Finals will be 12:30 p.m. on Thursday. An initial source "couldn't confirm or deny." A secondary source confirmed that Game 6 will indeed be at 12:30 p.m. with the Hawks playing at 8 p.m. instead of 7 p.m. #WNBA I @theixsports.bsky.social

Joshua G. Schraiber reposted

Replying to @sababausa.bsky.social

If the MSPB decision stands, it would effectively rewrite the whole principal officer / inferior officer framework by adding a huge "unless" to the "inferior officers can be protected from at-will removal" precedent

Joshua G. Schraiber reposted

Why it's important to consult a statistician before data collection, example 17445: If you collect data from 1000 patients, nested in 20 therapists, your effective sample size is much (much!) smaller than you think it is... 😏

Joshua G. Schraiber reposted

Replying to @jgschraiber.bsky.social

There is already a Fed. Cir. case on at-will removal of immigration judges (who are generally regarded as inferior officers) that might head to SCOTUS (oral argument in the Fed. Cir. case is scheduled for Dec. 10) bsky.app/profile/josh...

Josh Gerstein@joshgerstein.bsky.social

JUST IN: Federal Circuit agrees to highly unusual initial en banc review in immigration judges' challenge to Trump claim he has presidential authority to fire them at will. Argument likely October or later, though. Doc: www.documentcloud.org/documents/28...

Joshua G. Schraiber reposted

This, but also, as a liberal I believe in freedom and human rights for all people, all around the world. That translates into rooting interests in elections where freedoms and rights are on the ballot, as they often are.

Dan Mauler 🎃@meelar.bsky.social

I just think Matt's wrong about this. We're at a point in our technological development where a ton of problems spill over national borders--if Flavio Bolsonaro burns down the Amazon, that will flood houses in Miami.

Joshua G. Schraiber reposted

Maybe 20 years ago but it just feels so odd to hear this idea expressed by a respectable mind now. Isn't it beyond dispute that governance spillovers are now so huge that it's morally indefensible not to "care"? Would anyone say people from other countries should be indifferent to who POTUS is?

Joshua G. Schraiber reposted

Replying to @jamellebouie.net

interestingly this interest in black voters doesn’t extend to the republican effort to deprive them of federal representation, nor do they seem interested in asking whether republican candidates are burdened by the fact that trump talks like a klansman

Joshua G. Schraiber reposted

pundits are basically bored by the idea that these democratic candidates are not meaningfully behind with black voters and so are trying to conjure a controversy into existence

Ariel@ari-el222.bsky.social

he’s also given multiple speeches on this and has really been trying with outreach both during the primary and now. I think the media just really wants Black voters to abandon Dems. Talarico had more time to show this narrative was completely bunk but it really mirrors that coverage too

Joshua G. Schraiber reposted

There is an international, well-connected network of fascists promoting far-right candidates in elections (and coups) across the world. The guy who owns the site Yglesias posted this on is one of their leaders. Be careful of people advocating for their opponents to disarm!

Dan Mauler 🎃@meelar.bsky.social

I just think Matt's wrong about this. We're at a point in our technological development where a ton of problems spill over national borders--if Flavio Bolsonaro burns down the Amazon, that will flood houses in Miami.

Joshua G. Schraiber reposted

Boston’s chief planner is a true believer in the San Francisco model, in which you make it impossible to profitably build apartments by-right so developers are forced into a politicized discretionary negotiation with the city, which relaxes the rules in exchange for below-market units.

This post is unavailable.

Joshua G. Schraiber reposted

betting markets on elections are extremely obviously biased to right-wingers winning, largely because far more right-wingers bet and a disproportionate number of them are deeply stupid and in denial about who supports them occasionally they figure out that some Dems are safe, etc but other times...

Joshua G. Schraiber reposted

Yeah, my biggest takeaway from the Anty S-1 is the groundhog didn't see its shadow, so add another 6 quarters on to whenever you think computer hardware will be affordable again.

Micah@rincewind.run

bubble’s not popping anytime soon if anthropic is making this kind of money off claude, even if capex costs are still absurd

Joshua G. Schraiber reposted

bubble’s not popping anytime soon if anthropic is making this kind of money off claude, even if capex costs are still absurd

The unit economics here are frankly shocking they're so good. This is wildly stronger than I expected tbh.

Joshua G. Schraiber reposted

Replying to @peark.es

85% inference margin, training costs are well below that. Really remarkable.

Joshua G. Schraiber reposted

Replying to @peark.es

The unit economics here are frankly shocking they're so good. This is wildly stronger than I expected tbh.