Max Gutierrez

In the age of generative AI, the assumption that writing a paper requires doing science does not hold. This Perspective by @blekhman.bsky.social argues that the field's response to AI-generated papers should be predicated on clarity of purpose for bioresearch. 🧪 #AcademicSky plos.io/47wZsKo

Less than 5% chance!!! Come on @erc.europa.eu We need to find a solution. Otherwise, we will lose a generation of young researchers.

Need help analysing your image data? Don't know where to start? Have you heard about @uk-bias.bsky.social ? Come along to our first online helpdesk, hosted by @lankylaste.bsky.social and Anneliese Jarman, to find out more - details below.

🚨4-year PhD position with @tinearnvig.bsky.social and me How do genetically identical bacteria generate multiple phenotypes, maximising survival in case of sudden catastrophes like nutrient starvation or host immunity?

None of this year's science Nobel Prizes have gone to women. The number of these prizes to go to women remains at 27 out of more than 600. See how many you can name in our quiz: www.nature.com/immersive/d4...

💥Very happy to see this work out! Fantastic work from former PhD student Beren Aylan on single cell dynamic reporters in Mtb using unstable mWasabi. So many people helped along the way, in particular Laure Botella, Pierre Santucci @pierresantucci.bsky.social Tony Fearns and Teresa Cortes 🥳

Looking for a PhD? @crick.ac.uk PhD applications for next year are open. 4 year program with lots of outstanding projects on offer. If you are interested in viral host interactions, cytoskeleton, cell bio, live cell imaging - see Way lab project + video. plz repost www.crick.ac.uk/careers-and-...

Guys! @jbahler.bsky.social and I are recruiting a PhD student in this round - if you know great undergrads or Masters students please tell them about us! And Crick in general, of course ;) Thank you!!

Out Now! Oncogenic viral infection triggers LAMP2A SUMOylation and chaperone-mediated autophagy to promote tumorigenesis #MicroSky

“I think what motivates me to work on TB is that I always wanted to work on something relevant and important for humans.” Watch @maxgg.bsky.social discuss his journey to developing new methods to visualise TB and antibiotics inside cells. https://youtu.be/wzGqJszqh-s

If financial barriers are keeping you from Tuberculosis: Basic Science Addressing Clinical Needs in London, don't let them hold you back. 🌍 GHTAs for LMIC scientists cover registration, airfare, lodging, ground transport to attend. Apply by Sept. 29th! Join us March 1–4, 2027.

Our study on DFCP1 and lysosome membrane repair is live! We uncover a previously unrecognized role for omegasomes in the cellular response to lysosomal membrane damage, revealing another layer of regulation in how damaged lysosomes are repaired. www.nature.com/articles/s41...

ICYMI: New online! Mycobacterium tuberculosis outpaces antibiotic treatment

The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophages journals.biologists.com/jcs/article/... Read more about this research in our ‘First person’ interview with Rebecca Morrison: journals.biologists.com/jcs/article/...

A common LRRK2 variant sensitises macrophages to cell stress Highlighting papers from Rebecca Morrison, Enrica Pellegrino, Sila Ultanir, @maxgg.bsky.social & colleagues and @andresgoldman.bsky.social, @mitodynamics.bsky.social @theneuro.bsky.social & team. journals.biologists.com/jcs/article/...

Very pleased to announce that my Crick postdoc work has just been published in Nature Communications: www.nature.com/articles/s41... Big thank you to @bpradel.bsky.social, @jaksonluk.bsky.social, @maxgg.bsky.social and the rest of the host-pathogen interactions in TB lab that made it all possible!

Five years ago I started studying a fascinating protein of Salmonella, called SteC.

Salmonella effector kinase SteC is activated by phosphorylation at Serine 379 dx.plos.org/10.1371/jour...

tracking a single-cell mycobacterium tuberculosis infection across time

📯 Our paper “VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair” out now in Nature Communications rdcu.be/frKmN

Recruiting a postdoc to join my lab at @lshtm.bsky.social to work in an MRC porgramme grant funded project to dissect the gut colonziation by Klebsiella. In vivo and in vitro models, and new approaches to identify Klebsiella factors involved. jobs.lshtm.ac.uk/vacancy.aspx...

Great collaboration with @adrianisaacs.bsky.social showing coordinated role for FTD/ALS proteins CHMP2B and ANXA11 in membrane repair! Well done Catherine Heffner, Georgina Starling, Lorian Cobra Straker and Pippa Hawes! @crick.ac.uk, @ukdri.ac.uk, @kingslsm.bsky.social. www.cell.com/developmenta...

Check out our latest T7SS toxin story. These reverse toxins aren’t as rare as we thought!

How does a cell remodel the ER membrane into a lipid droplet? Excited to share our new bioRxiv preprint, where we find that regulated opening of the seipin ring defines a functional ER–lipid droplet interface — and identify SMLR1 as a regulator of this transition. www.biorxiv.org/content/10.6...

Our image competition with #ELMI2026 could hardly be closer with just 3 votes separating the top 2 images, with three others close behind. If you haven’t voted yet, you have until 23:59 BST tonight (18 June) to register your vote! focalplane.biologists.com/2026/06/08/f...

I'm incredibly proud to share our paper on the preclinical evaluation of the BNT164 mRNA tuberculosis vaccine candidates. Now online in the final version at Nature Immunology. www.nature.com/articles/s41...

BacPROTACs outperform inhibitors in Mycobacterium tuberculosis https://www.biorxiv.org/content/10.64898/2026.06.12.731830v1

One week left to apply. Help us find new antimicrobials and understand the inner workings of bacteria – as a technical assistant in the Machine Biophotonics and Nanoscale Bacteriology labs at the Rudolf-Virchow-Zentrum, University of Würzburg – See details below (in German). Please spread the word.

Very excited this work by Victor and Jakson @crick.ac.uk is out!! started many years ago with @jvaubourgeix.bsky.social They generated Mtb-Timer, a fluorescent reporter in Mtb as a proxy for Mtb replication and measure antibiotic responses Mtbhttps://journals.asm.org/doi/10.1128/msystems.01796-25

The weekend is coming - use it to plan a trip to Belfast for the 2026 UK Cellular Microbiology Meeting! Submit an abstract until 12th of May! Great opportunity for early career researchers! www.ukcellmicro.org

Nice demonstration by @maxgg.bsky.social et al that some, but not all, non tuberculous mycobacteria (NTM) intracellular growth in macrophages is pH sensitive #TBSky #immunosky onlinelibrary.wiley.com/doi/10.1111/...

Really important and relevant study in TB from @danbarberphd.bsky.social and colleagues. We need to re-think many assumptions. Nitric oxide production in mice has been a confounding factor. #tuberculosis

The 2026 UK Cellular Microbiology Network Meeting is approaching fast! Submit an abstract until May, 12th and join us June, 22nd/23rd in Belfast! Exiting keynote speakers and opportunities for early career researchers from the UK, Ireland and beyond to share their work. www.ukcellmicro.org

Was just asked to spread the word about this position. Structural biology and Chemical Biology positions in Barcelona, one of the great cities of the world! www.irbbarcelona.org/sites/defaul...

The time has come for big changes to research funding. New piece by RoRI’s Peter Kolarz on why incremental fixes may no longer be enough: journals.plos.org/plosbiology/...

In this systematic review & meta-analysis, Mortazavi & colleagues (@petermacp.bsky.social) investigate urban vs rural differences in #TB prevalence between 2000 and 2024 in 26 low- and middle-income countries, finding that TB epidemics have become increasingly urbanized 🧪 #MedSky plos.io/3O79BqY

We are looking for an experienced light microscopy specialist, motivated to support our users in the Advanced Light Microscopy Facility at EMBL Heidelberg. embl.wd103.myworkdayjobs.com/en-US/EMBL/j... -closing date 11 May 2026 @eurobioimaging.bsky.social @globalbioimaging.bsky.social

💥Our latest @embojournal.org on membrane damage and repair. Di @dichen02.bsky.social @crick.ac.uk found that calcium is a conserved signal for ATG8/LC3 lipidation on membranes using novel probes to record calcium leakage. Congratulations Di et al! link.springer.com/article/10.1...

‼️ A really good meeting for people working on host-pathogen interactions! Great keynote speakers this year: Raphael Valdivia and Florence Niedergang. Please repost!

Now this is the future of TB research 👏 39 Keystone Symposia & @gatesfoundation.bsky.social scholarship awardees at #KSTB26. With ~1.5M TB deaths each year, these early-career scientists are driving progress through collaboration and new ideas. @maxgg.bsky.social @breealdridge.bsky.social

All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy? Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation. www.nature.com/articles/s41... (1 out of 3)

We know how to end TB. What’s missing is the will to change the systems that keep it spreading. Ahead of #WorldTBDay, SAO is highlighting an overlooked TB risk, the international monkey trade, & why human‑centered research is a better (safer) path forward. 🔗 www.linkedin.com/pulse/yes-we...

“Measures to strengthen international biosafety and biosecurity practices” There is an absolute necessity for research on ‘pandemic-prone pathogens’. Studies must, however, be conducted responsibly & according to strict principles of safety & security This outlines steps for global accountability

New lab preprint! @zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes 🧵 tinyurl.com/ukny4ptz

Very excited to share our recently published work on NTM and their response to acid stress! As my first paper, I’m especially grateful for the support and guidance from @luizcarvalholab.bsky.social , Rachel and @maxgg.bsky.social . More to come!

Great to see this. Many years ago I found a complete set of >100 years of Quarterly Journal of Microscopical Science (predecessor to J Cell Sci) in a Dutch antiquarian book store. We scanned these as PDFs but COB have now converted the full archive to HTML 👏

I’m pleased 🤗 to share our new preprint exploring the mode of action and resistance of the antitubercular drug pyrazinamide (PZA) 💊 Thanks to everyone who have participated 🙌 We hope these findings will help the fight against drug resistance in tuberculosis. www.biorxiv.org/content/10.6...

We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum. First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social rdcu.be/ezBl7