N End Rules

My first @bsky.app post could only be #crossing two accessions of #arabidopsis from very different 🏔️ #genetics #plantscience a kind of meditation.

Many thanks to all the participants, for the interesting and fascinating talks. Great discussions and great science! See you at the next meeting 🧪🌱

Increased signaling of the Neanderthal growth hormone receptor http://dlvr.it/TW0r3t Hugo Zeberg @i.se & others @currentbiology.bsky.social #ASHG26

🌱Our new preprint in @biorxiv-plants.bsky.social uncovers a novel role for Toc90 in regulating chloroplast senescence and photosynthetic protein abundance in Arabidopsis. 📄:https://www.biorxiv.org/content/10.64898/2026.09.29.755046v1

We're delighted to share our latest paper published today in @currentbiology.bsky.social . www.cell.com/current-biol... We use comparative transcriptomics and microscopy to show that this tiny structure contains a fusion of a compressed stem and a leaf.

Mutations in SUMO conjugating enzyme reveal contributions of sumoylation to plant stress resilience and yield Lilian Nehlin, et al. nph.onlinelibrary.wiley.com/doi/10.1111/... #PlantScience

Had a UKRI funded grant proposal rejected at the "AI triage stage". "This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review." 🧪 #academicsky

Can @ukri.org tell us what AI thinks makes a good proposal so that we can write our proposals in that way? This is an extremely poor decision. Why not just put all internationally competitive proposals in a hat and pull them out randomly? That at least would be transparent.

Great to see such detailed and continuing work on COMATOSE including cryo-EM structures! Structural insights into Arabidopsis thaliana CTS-mediated fatty acid and hormone metabolism www.nature.com/articles/s41...

Coenzyme A biosynthesis is regulated by two distinct Ubiquitin E3 ligase complexes | UBR4-KCMF1 and MKLN1-CTLH independently converge on a common N-terminal MK Arg/N-degron to promote PANK degradation and restrict CoA biosynthesis | @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.6...

7.3% funding rate, if lucky. Who is going to read this, how do you make an objective decision (different (types) of reviewers)? I will die on this hill: If the funding rates do not go up, a lottery in the top 25% is more fair than arbitrary human decisions, I doubt you will go wrong in that cohort.

Hello, Proteostasis Community!🌱 We’re excited to finally share with you the final program of our conference!🎉 Join us in the charming city of Strasbourg from October 14th to 16th for three days of exciting science and inspiring discussions! 🧬 🧪 Stay tuned for more updates!

Our paper is out! 🤩 HYT1, a new Cys2- substrate of the #Ndegron pathway to add to the list! 🌱 Thanks to @n-end-rules.bsky.social @charlene-kunaka.bsky.social @gunjansharma88.bsky.social , Susana and all the people involved in this work! You can read it on @natcomms.nature.com👇🏼

Many of you may have heard the terrible news of Dr. Meng Chen's sudden death. I just found this tribute from UC Riverside cnas.ucr.edu/news/2026/09... and a beautiful review article he contributed to @plantphys.bsky.social earlier this year, "25 years of photobodies" doi.org/10.1093/plph... 💔

Hierarchical regulation of oxygen-sensing through coupled transducers in Arabidopsis thaliana www.nature.com/articles/s41... New #plantscience work by @isamanrique.bsky.social @charlene-kunaka.bsky.social @gunjansharma88.bsky.social @n-end-rules.bsky.social

Rubisco, a CO2-fixing enzyme and a major reservoir of nitrogen and carbon in plant leaves, requires a unique N-terminal maturation pathway | Dong Xie et al. @giglionelab.bsky.social @ifink-lab.bsky.social www.science.org/doi/10.1126/...

Radial #oxygen loss, rhizospheric #methane oxidation and methane emissions from #rice roots Juan de la Cruz Jiménez, et al. nph.onlinelibrary.wiley.com/doi/10.1111/... #PlantScience

Our work, Progressive oxygenation of developing leaves directs morphogenesis, is now out in Science Advances! We found that developing leaves oxygenate from tip to base, strikingly mirroring their developmental axis, and this drives leaf dev. www.science.org/doi/10.1126/sciadv.aef2430 #plantscience

Progressive oxygenation of developing leaves directs morphogenesis Exciting #plantscience work by @daanweits.bsky.social @panicuccigabriele.bsky.social @syno2xis.bsky.social out now in Science Advances www.science.org/doi/10.1126/...

Protein synthesis is dynamically responsive to the environment, but how do cells ensure that their protein quality control mechanisms are appropriately scaled to changing translational demand? We address this question in our new study in @natcomms.nature.com www.nature.com/articles/s41...

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

The RAP2.12 and RAP2.3 factors act downstream of LRR-MAL Receptor Kinases in Arabidopsis pollen-stigma interactions. https://www.biorxiv.org/content/10.64898/2026.08.24.746730v1

Chemical priming of hypoxia responses via PLANT CYSTEINE OXIDASE inhibition improves flooding tolerance academic.oup.com/plphys/artic...

Oxygen sensing in plants: from dynamic hypoxia signalling to the expanding roles of the Cysteine N-degron pathway academic.oup.com/jxb/article/...

#PlantSciJobs #PlantSciJob PostDoc position (3 + 2 years) Protein biochemistry or molecular plant sciences @Uni Osnabrück, Germany Start: as soon as possible Deadline: 31. August 2026 www.deutsche-botanische-gesellschaft.de/en/job-openi...

In memory of Professor Tamara Vasilievna Chirkova (1932 -2026). She pioneered research on plant adaptation to oxygen deficiency and laid a robust foundation for the advancements we witness today. #plantscience sites.google.com/ucr.edu/ispl...

Functional diversification of UBP6 in plant immunity through N-degron pathway regulation https://www.biorxiv.org/content/10.64898/2026.07.24.740541v1

Our new preprint shows that metacaspase-mediated proteoform generation and N-degron pathway-dependent proteoform stability act together to diversify UBP6 function during Arabidopsis immunity www.biorxiv.org/content/10.6...

New preprint: In collaboration with @yorgsvicen.bsky.social we show metacaspase9 and ATE N-degron pathway-dependent proteoform stability act to diversify UBP6 function during plant immunity www.biorxiv.org/content/10.6...

FTFY

We developed genetically encoded FRET-based biosensors to visualize protease activity in living plant cells with high spatial and temporal resolution. (2/5)

Today marks a huge milestone in my career. I am proud to be announced as one of the new BBSRC Discovery Fellowship awardees, with a grant close to the value of £500 000

I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇

Over the last month I saw that human editors are now stripped of control. I could no longer stop the system from auto-inviting "reviewers" with zero relevant expertise. Even worse - the AI began actively revoking the invitations I manually sent out to actual, qualified experts.

Cool new T-DNA plasmid! Let's see how it gets adopted and common tools become available -- hope those will happen to some level at least www.biorxiv.org/content/10.6...

The final version of our @annualreviews.bsky.social article is now published OPEN ACCESS www.annualreviews.org/content/jour...

The N-degron pathway regulates glucose and insulin homeostasis through the lysosomal degradation of RXRA/RXRα via SQSTM1/p62: Autophagy: www.tandfonline.com/doi/abs/10.1...

New review out on protein N-terminal formylation - a stress-inducible modification of eukaryotic proteins #N-degron @ispt-proteinterm.bsky.social www.nature.com/articles/s12...

An oxygen-sensing Polycomb-group protein encodes flooding stress memory in plants https://www.biorxiv.org/content/10.64898/2026.05.01.722198v1

So happy and proud to share our lab’s first #plantscience research article, revealing that angiosperms have the capacity to encode memory of flooding stress. A heroic effort by @aidamaric.bsky.social in collaboration with @djgibbs.bsky.social and others. A brief 🧵 www.biorxiv.org/content/10.6...

Is this the end of science as we know it? mikhoelias.substack.com/p/how-ai-bre...

For those who missed this at the other place: open.substack.com/pub/mikhoeli...

University of Nottingham set to cut 600 jobs in major cost-cutting move #Nottinghamshire #Notts

N-terminal cysteine dependent proteolysis of RGS4/5 is not sensitive to physiological oxidative stress | Preprint by Ya-Min Tian, Haeun Kim, Peter Ratcliffe & Thomas Keeley @ox.ac.uk @ispt-proteinterm.bsky.social #N-degron #cysteine www.biorxiv.org/content/10.6...

We knew PCOs & ERFVIIs regulated plant hypoxia, but this work shows they also manage the 'reoxygenation' stress. www.nature.com/articles/s41... @biology.ox.ac.uk @ox.ac.uk @uni-muenster.de

🎉 Thrilled - our new Nature Chemistry paper identifying H3K9acOH, a new histone PTM formed by JmjC oxygenase KDM3A - revealing an O2‑dependent PTM in chromatin regulation. Congrats to CRUK KDM team in the Kawamura & Schofield groups & thanks to our amazing collaborators! 📄 rdcu.be/fdx4f #Epigenetics

Generation of Brassica napus with enhanced Sclerotinia sclerotiorum resistance through CRISPR/Cas9‐mediated inhibition of the PROTEOLYSIS6 N‐degron pathway Lin et al. nph.onlinelibrary.wiley.com/doi/10.1111/...

The N-degron pathways move from basic to applied science. This pathway will prove to be of key importance for agricultural improvement. Very happy to have been a part of this work led by Chen Lin and colleagues. #plantscience #nendrule #hypoxia nph.onlinelibrary.wiley.com/doi/10.1111/...

🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 www.science.org/doi/10.1126/... #EvoDevo