Fitz-James Lab

Fitz-James Lab

@fitz-james-lab.bsky.social

Molecular biology lab based at the Department of Biology, University of Oxford. Researching insect epigenetics and epigenetic inheritance.

2.2K followers1K following39 posts

Fitz-James Lab reposted

Takashi Akera Lab
@takashiakeralab.bsky.social

We are hiring POSTDOC now!🚨please repost! Fully-funded 5-year position πŸ‘©πŸ»β€πŸ”¬πŸ‘¨β€πŸ”¬πŸ§¬Looking forward to your application!βœ‰οΈ

Fitz-James Lab reposted

Fena Ochs
@fenaochs.bsky.social

We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...

nature.comPostdocs at Center for Gene Expression in Department of Cellular and Molecular Medicine - Copenhagen, Hovedstaden (DK) job with University of Copenhagen | 12849488We are looking for 2 or more highly motivated postdocs interested in ribosome biology, 3D chromatin organisation, or regulation of protein turnove...

Fitz-James Lab reposted

Ben Carty
@bencarty.bsky.social

Very proud to have our latest work now online in @natsmb.nature.com. A wonderful team effort across the centromere community, across @jansenlab.bsky.social @naltemose.bsky.social @dfachinetti.bsky.social and Giunta labs. Happy reading! 1/4 www.nature.com/articles/s41...

nature.comHeterochromatin boundaries maintain centromere position, size and number - Nature Structural & Molecular BiologyCarty et al. identify the H3K9 methyltransferases that restrict the size and position of the centromere protein A chromatin domain, maintaining functional centromeres.

Fitz-James Lab reposted

Mark A. Hanson
@hansonmark.bsky.social

WE ARE RECRUITING PHD STUDENTS!!! We have three(!) funded PhD studentships advertising presently. If any of these are of interest, please reach out! Thread below with links to more information on each project. #Drosophila #Evolution #Immunity #SelfishGene #Aphids Thread with links below 🧡 1/4

Fitz-James Lab
@fitz-james-lab.bsky.social

It’s been a big month for the lab! We’ve gone from just me to six in as many weeks. I’m so excited to embark on this new chapter with these wonderful people, and I’m looking forward to the exciting science πŸ§ͺwe’ll be doing together in the new Life and Mind Building @biology.ox.ac.uk #epigenetics

Fitz-James Lab
@fitz-james-lab.bsky.social

Great opportunity in a fun lab / cool city!

Mike Robson@drmrobson.bsky.social

Postdoc🚨! Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro

mdc-berlin.deWissenschaftliche*r Mitarbeiter*in/ Postdoc (m/f/d)Chromatin ist nicht unbeweglich. Es handelt sich um ein hochdynamisches Material, dessen 3D-Struktur zentrale genomische Prozesse – von der Transkription bis zur DNA-Reparatur – steuert. Doch wie verhΓ€lt sich Chromatin als Material – als FlΓΌssigkeit, Feststoff oder viskoelastisches Gel –, um diese Funktionen in lebenden Zellen auszufΓΌhren? Ohne eine Antwort auf diese Frage kΓΆnnen wir nicht vollstΓ€ndig verstehen, wie Chromatin bei Krankheiten gestΓΆrt wird.

Fitz-James Lab reposted

Magdalena Skipper
@magdalenaskipper.bsky.social

From today, every paper submitted to Nature -if published - will be accompanied by peer reviewers comments & authors rebuttal. We started the trial in 2020; we now want to open up the review process & showcase its role in shaping & improving papers πŸ§ͺ #AcademicSky www.nature.com/articles/d41...

nature.comTransparent peer review to be extended to all of Nature’s research papersFrom today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses β€” to illuminate the process of producing rigorous science.

Fitz-James Lab reposted

Berta Verd
@bertaverd.bsky.social

Experimental embryology postdoc available in my lab at the @biology.ox.ac.uk @ox.ac.uk working on the evolution of vertebral counts. Reach out if you’re passionate about EvoDevo, enjoy lab work and microscopy and are into or could get into cichlid fishes. Deadline on the 16th June. Please share!

Fitz-James Lab
@fitz-james-lab.bsky.social

Very cool paper combining two of my favourite things: phylogeny and genome organisation

Iana V. Kim@ianakim.bsky.social

I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...

nature.comChromatin loops are an ancestral hallmark of the animal regulatory genome - NatureThe physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...

Fitz-James Lab reposted

Fly Journal
@fly-journal.bsky.social

Fly journal is now on BlueSky! The world’s only academic journal dedicated to research on Drosophila & cognate insects. A fully open-access journal that combines rapid publication with high standards of peer-review. For further info and how to submit your work, see the link.

tandfonline.comFlyOpen access research on Drosophila developmental/evolutionary biology, organogenesis, neurobiology, circadian rhythms, learning & memory, sex determination

Fitz-James Lab reposted

Flora Paldi
@fpaldi.bsky.social

Our new review in @cp-trendscellbio.bsky.social is now online! We discuss the connection between the epigenome, 3D genome folding, gene expression and cellular memory, specifically in loop extrusion-independent contexts.

Trends in Cell Biology@cp-trendscellbio.bsky.social

3D genome folding in epigenetic regulation and cellular memory

dlvr.it3D genome folding in epigenetic regulation and cellular memoryThe 3D folding of the genome is tightly linked to its epigenetic state which maintains gene expression programmes. Although the relationship between gene expression and genome organisation is highly context dependent, 3D genome organisation is emerging as a novel epigenetic layer to reinforce and stabilise transcriptional states. Whether regulatory information carried in genome folding could be transmitted through mitosis is an area of active investigation. In this review, we discuss the relationship between epigenetic state and nuclear organisation, as well as the interplay between transcriptional regulation and epigenetic genome folding. We also consider the architectural remodelling of nuclei as cells enter and exit mitosis, and evaluate the potential of the 3D genome to contribute to cellular memory.

Fitz-James Lab reposted

Sheppard Lab
@sheppardlab.bsky.social

TWO postdoc positions in Computational Microbiology and/or biochemistry. Join our interdisciplinary group in the new Life and Mind Building @OxfordBiology, @UniofOxford, @IneosOxford Please apply and share this post: www.jobs.ac.uk/job/DMP641/p...

jobs.ac.ukPostdoctoral Research Associate at University of OxfordDiscover Postdoctoral Research Associate jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.
Fitz-James Lab
@fitz-james-lab.bsky.social

7/10 As controls for our sRNA pathway mutants we used some well-known marker mutations on the same chromosome. One of these, mutation in the gene Stubble (Sb) which is well-known to Drosophila enthusiasts, had a clear effect on eye colour, making it more red.

Fitz-James Lab
@fitz-james-lab.bsky.social

5/10 We decided to investigate whether sRNAs were contributing to Fab2L eye colour and its inheritance. First, we sequenced sRNAs in a variety of Fab2L lines with epigenetic and phenotypic differences. But we found no sRNAs mapping to the eye colour gene.

Fitz-James Lab
@fitz-james-lab.bsky.social

6/10 Next, we tested an array of mutants in sRNA pathways. Again, we found no effect of the mutations on eye colour, arguing against a role for sRNAs in eye colour. However, a surprising result involving one of our controls jumped out at us…

Fitz-James Lab
@fitz-james-lab.bsky.social

3/10 But is H3K27me3 the only epigenetic information involved? Epigenetic signals often work together, making it hard to tell if a particular signal is truly inherited, or simply reconstructed in each generation based on another inherited signal.

Fitz-James Lab
@fitz-james-lab.bsky.social

4/10 In many organisms (C. elegans, plants…) small non-coding RNAs are known to be passed through the germline and are often considered the true directly inherited signal, with other epigenetic signals being derived from them.

Fitz-James Lab
@fitz-james-lab.bsky.social

2/10 The Drosophila Fab2L line has an epigenetic eye colour phenotype inherited across generations. Eye colour is determined by variation in H3K27me3 levels, and we recently investigated the mechanism by which differences in this mark first arise and become heritable. www.cell.com/molecular-ce...

cell.comInterchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in DrosophilaIn some cases, non-genetic information can be inherited across generations. Fitz-James etΒ al. investigate the mechanism by which such epigenetic information becomes heritable in fruit flies. They show...

Fitz-James Lab reposted

Alicia Hidalgo Lab
@aliciahidalgolab.bsky.social

Postdoc opportunity in UK, Wellcome funded, 3 years, to investigate neurogenetics underlying how the brain changes throught life: plasticity vs degeneration. Drosophila, imaging, behaviour. Candidates of all nationalities welcome. Application deadline 19 March. Pls repost. #Drosophila #postdoc #job

Fitz-James Lab
@fitz-james-lab.bsky.social

Wow! Incredibly grateful to Jessica Hawes and Alyson Ashe for their very kind preview of our paper for the current issue of Mol Cell! @cellpress.bsky.social www.cell.com/molecular-ce...

cell.comMoving epigenetic inheritance into the space age: Evidence that 3D genome organization is required for the establishment of epigenetic memoryIn this issue, Fitz-James etΒ al. use genetic manipulations to show that transient interchromosomal contacts between distant regulatory elements, mediated by the transcription factor GAF, can initiate ...
Fitz-James Lab
@fitz-james-lab.bsky.social

Still two weeks left to apply to join the lab in Oxford @biology.ox.ac.uk for an exciting project on #epigenetic inheritance in #Drosophila !

Fitz-James Lab@fitz-james-lab.bsky.social

We are looking for a post-doc to join us in Oxford @biology.ox.ac.uk to study epigenetic inheritance! The project will use Cut&Run and RNA-seq to map and track new epimutations as they arise in Drosophila populations across multiple generations. Feel free to share! my.corehr.com/pls/uoxrecru...

Fitz-James Lab
@fitz-james-lab.bsky.social

Very excited to be setting up my lab @biology.ox.ac.uk and looking forward to growing the team in the coming years!

Oxford Biology@biology.ox.ac.uk

Congratulations to @fitz-james-lab.bsky.social, who has been awarded a Wellcome Career Development Fellowship! His research focuses on the molecular mechanisms behind Transgenerational Epigenetic Inheritance: how non-genetic information is transmitted across generations πŸ‘‡ bit.ly/4gGQgFi

bit.lyDr Max Fitz-James awarded Wellcome Career Development Fellowship

Fitz-James Lab reposted

The Groth lab
@grothlab.bsky.social

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀π₯𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring πŸ” 𝐏𝐑𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC)Β in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

tinyurl.com6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.
Fitz-James Lab
@fitz-james-lab.bsky.social

I can highly recommend a great programme to come work at a very welcoming place!

Oxford Biology@biology.ox.ac.uk

Applications are open for our Independent Research Fellowship Mentorship Programme! The programme supports promising early career researchers to submit fellowship applications and move towards research independence. If you’re looking to make the move, full details are on our websiteπŸ‘‡ bit.ly/BioIRF

bit.lyFellowships

Fitz-James Lab reposted

Berta Verd
@bertaverd.bsky.social

I am recruiting an #ERC funded PostDoc to work on the evolution of vertebral counts in cichlids. This is an experimental project & will be looking for candidates with experience generating reporter lines, live-imaging and experimental embryology. Application deadline: 25th Feb. tinyurl.com/33jbu8fa

Fitz-James Lab reposted

Ivana Jerkovic
@ivana-jerkovic.bsky.social

We seek a bioinformatician to join our group at the College de France, Paris. If you like genomics, 3D genome organization, gene regulation, and development check out the offer and get in touch!