Reid Oshiro

Reid Oshiro

@rtoshiro.bsky.social

Postdoc; Schrader lab, IU Biology | PostDoc; Seed lab, UC Berkeley | PhD, Microbiology; Kearns lab, IU Biology | Love microbiology and baking! HI ➡️ IN ➡️ CA ➡️ IN| he/him 🏳️‍🌈

244 followers281 following12 posts

Reid Oshiro reposted

Saria McKeithen-Mead, PhD
@sciria.bsky.social

Pleased to share my first preprint from my postdoc, where I ask what drives mobile DNA movement between bacterial cells in complex communities like the gut microbiome. To answer this, we built a way to capture mobile DNA in the act of moving between cells, using short-read metagenomics. 🧵

doi.orgdoi.org

Reid Oshiro reposted

Jan-Ulrik Dahl (Dahl lab, ISU)
@janulrikdahl.bsky.social

Join us and become my colleague! The School of Biological Sciences is opening the search for an Assistant Professor in the field of Host-Microbe Interactions with the targeted start date of Fall 2027. Please reach out to me with any questions you have: jobsearch.illinoisstate.edu/jobs/assista...

jobsearch.illinoisstate.eduASSISTANT PROFESSOR IN HOST-MICROBE INTERACTIONS (IMMUNOLOGY, MICROBIOLOGY) - Normal, Illinois, Illinois, United StatesTitle: ASSISTANT PROFESSOR IN HOST-MICROBE INTERACTIONS (IMMUNOLOGY, MICROBIOLOGY)Employee Classification: Asst ProfessorDivision Name: Academic AffairsCollege/Unit: College of Arts and SciencesDepart...

Reid Oshiro reposted

artemisaev.bsky.social
@artemisaev.bsky.social

Chromatin structure controls defense island expression! Why do some systems defend on plasmids but fail natively? H-NS is key. Removing it boosts defense and overcomes anti-defense proteins but raises toxicity. Common lab strains still hide novel immunity modules! www.biorxiv.org/content/10.6...

biorxiv.orgH-NS silences antiviral immunity through 3D chromatin compactionBacterial antiviral immunity systems can be toxic to their hosts and must be tightly regulated. Immunity genes are often encoded by AT-rich mobile genetic elements subjected to silencing by nucleoid b...

Reid Oshiro reposted

artemisaev.bsky.social
@artemisaev.bsky.social

Thrilled to share! We present the structure of a prototypical P2 OLD and reveal that its tRNAse activity is triggered by ssDNA hairpins in phage origins or unresolved termini in RecBCD-deficient cells. Great team effort with Wang, Bikard & Nudler labs. www.biorxiv.org/content/10.6...

biorxiv.orgOLD sentinel: an abortive tRNase surveys phage replication and DNA defects in RecBCD-compromised cellsOLD, an abortive immunity protein from prophage P2, consists of an ABC ATPase sensor and a TO-PRIM nuclease effector - a core architecture shared by a large protein family, including components of ant...

Reid Oshiro reposted

Taga Lab
@tagalab.bsky.social

Are you interested in #phages? The Taga Lab is looking to hire a postdoc with expertise in phage biology to work on a project about phage-mediated nutrient sharing. If you're interested, please reach out to Dr. Taga.

Reid Oshiro reposted

Nature Microbiology
@natmicrobiol.nature.com

Out Now! A phage protein screen identifies triggers of the bacterial innate immune system #MicroSky

go.nature.comA phage protein screen identifies triggers of the bacterial innate immune systemNature Microbiology, Published online: 16 January 2026; doi:10.1038/s41564-025-02239-6A library of 400 phage protein-coding genes is used to find a trove of antiphage systems, revealing systems that target tail fibre and major capsid proteins.

Reid Oshiro reposted

Christina Stallings
@stallingslab.bsky.social

Registration is open for the 2026 Gordon Research Conference on Microbial Stress Response to be held on July 19-24 2026!! Submit your abstract by February 15th to be considered for a short talk. Apply now before it fills up!! Hope to see you there!! www.grc.org/microbial-st...

grc.org2026 Microbial Stress Response Conference GRCThe 2026 Gordon Research Conference on Microbial Stress Response will be held in South Hadley, Massachusetts. Apply today to reserve your spot.

Reid Oshiro reposted

New England Biolabs
@nebiolabs.bsky.social

Durham University (@durham.ac.uk) and NEB scientists described the first biochemical characterization of GmrSD Type IV restriction enzyme substrate specificity and inhibition by phage protein IP1*. https://royalsocietypublishing.org/doi/10.1098/rstb.2024.0072

royalsocietypublishing.orgModified DNA substrate selectivity by GmrSD-family Type IV restriction enzyme BrxUAbstract. Bacteriophages (phages), viral predators of bacteria, generate selection pressure that causes bacteria to evolve defence systems. Type I, II and

Reid Oshiro reposted

anna brogan
@apbrogan.bsky.social

Fer’s tour de force in B. anthracis is out! Fer got Tn-seq running, built an ordered knockout library, defined all essential sporulation genes, and found a peptidoglycan deacetylase inhibitor critical for engulfment. Including our first one-by-all Alphafold screen! journals.plos.org/plosbiology/...

journals.plos.orgIdentification of sporulation genes in Bacillus anthracis highlights similarities and significant differences with Bacillus subtilisHow good is Bacillus subtilis as a model for the spore-forming pathogen Bacillus anthracis? Using high throughput genetics to identify B. anthracis sporulation genes and cytological analysis of the mu...

Reid Oshiro reposted

Anthony Vecchiarelli
@cellforganized.bsky.social

Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University! GRS will be on June 5-6, 2027 GRC will be from June 6-11, 2027 Block off your calendars Prokaryotic Cell Biologists! More details to come! Please repost!

Reid Oshiro reposted

Joe Bondy-Denomy
@jbdsf.bsky.social

Phages are full of genes of unknown function that are likely adaptive in specific conditions. New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out tinyurl.com/bdcfrejh

Reid Oshiro reposted

Erez Yirmiya
@erezyirmiya.bsky.social

I’m happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life. www.biorxiv.org/content/10.6...

biorxiv.orgSystematic discovery of TIR-based immune signaling systems in bacteriaToll/interleukin-1 receptor (TIR) domains are important for immune signaling across humans, plants and bacteria. These domains were recently found to produce immune signaling molecules in plant immuni...

Reid Oshiro reposted

Michael Baym
@baym.lol

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/ www.science.org/doi/10.1126/...

science.orgIntracellular competition shapes plasmid population dynamicsFrom populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

Reid Oshiro reposted

Alexander Harms
@aharms485.bsky.social

🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8

Reid Oshiro
@rtoshiro.bsky.social

I’m excited to share my recent postdoc work. Here, we interrogate how different phage infection outcomes (productive vs. restrictive) affect the expression of phage defense systems. We find that a restricted infection not only inhibits the phage but also induces increased immune protein abundance.

bioRxiv Microbiology@biorxiv-microbiol.bsky.social

Surviving phage attack dynamically regulates bacterial immunity to defeat counterdefenses https://www.biorxiv.org/content/10.1101/2025.11.13.688357v1

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Reid Oshiro
@rtoshiro.bsky.social

unlinked Anti-plasmid system DdmDE, which has a predicted WYL protein encoded upstream of it. Our data suggests that these two WYL proteins (phage & plasmid defense) act independently of each other. We predict that bacteria can coordinate their immune response through multiple independent

Reid Oshiro
@rtoshiro.bsky.social

I’m excited to share my recent postdoc work. Here, we interrogate how different phage infection outcomes (productive vs. restrictive) affect the expression of phage defense systems. We find that a restricted infection not only inhibits the phage but also induces increased immune protein abundance.

bioRxiv Microbiology@biorxiv-microbiol.bsky.social

Surviving phage attack dynamically regulates bacterial immunity to defeat counterdefenses https://www.biorxiv.org/content/10.1101/2025.11.13.688357v1

Reid Oshiro
@rtoshiro.bsky.social

This boost in immune protein abundance, provided increased protection against phage-encoded counterdefenses. This dynamic regulation is dependent on a WYL-domain-containing protein, commonly associated with defense system. unexpectedly, we observe an increase in expression of the genetically

Reid Oshiro reposted

Melanie Blokesch
@mblokesch.bsky.social

Join the Blokesch lab (@EPFL) as a postdoc in Molecular Microbiology 🤩 Study Vibrio cholerae defense systems (phage/plasmid) in a dynamic, collaborative environment in Lausanne close to Lake Geneva in 🇨🇭! Please visit my lab's webpage for details about the position and how to formally apply.

Reid Oshiro
@rtoshiro.bsky.social

Attention phage/microbiology 🧫🦠enthusiasts- the Seed lab kimseedlab.com @UCBerkeley is hiring a staff research associate, an ideal opportunity for folks looking to gain research experience before grad school/professional school careerspub.universityofcalifornia.edu/psp/ucb/EMPLOY… please share!

kimseedlab.comSeed LabKim Seed is an Assistant Professor at the University of California, Berkeley and her lab studies the interactions between bacteria and their viral predators (bacteriophages), and how these interacti...

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