Sam Connell

Just published 🎉🥳 Two-photon #FLIM of NAD(P)H is a promising readout for cellular metabolic changes. However, multiplexing with fluorescent proteins is surprisingly hard🤔😅 ... But it can be navigated! www.cell.com/biophysrepor... @biophysreports.bsky.social

NWS San Diego has issued new Coastal Flood Warning for near-record/record-breaking tides and possible widespread coastal inundation in SoCal Sun-Thu. And there's no king tides or major storms in the mix yet...just elevated sea levels from extreme El Nino plus long-term warming.

In @jcb.org, @maggieutgaard.bsky.social, @myosincity.bsky.social, @pwoakes.bsky.social et al. show that #septins accumulate at the cortex in response to mechanical cues, where they serve to buffer mechanical forces that act on the #nucleus. rupress.org/jcb/article/... #Cytoskeleton #Mechanobiology

Check out our new paper in JCB today all about septins!

Beautiful paper from the @pwoakes.bsky.social lab. Stunning imaging, I love the experimental design, very intuitive. Pressing a glass bead on cytoplast induces Septin filaments is so cool! I always believe the best science is when you can answer with a simple experiment. doi.org/10.1083/jcb....

Why is this student so upset about the mushroom, though? What could it have done to make her protest across the whole continent

Our Dept. of Genetics and Developmental Biology at the Institut Curie in the heart of Paris is hiring a new junior PI. It has a nice start up package and excellent I. Curie facilities. Please spread the word: Deadline Dec. 18th! jpi-recruitment-curie-umr3215-u934.curie.fr

@bostonu.bsky.social is hiring! Up to 6 new neuroscience faculty positions! www.bu.edu/convergent-r... Send us your awesome neuroscientists and repost! 🌟

Anyone have recommendations for a decent, not too expensive, digital microscope for amateur home use to look at things like diatoms, tardigrades, fungi, etc?

Job! 🤩👀👇🏽

Our intravital imaging in adult zebrafish paper is officially up at JCS @jcellsci.bsky.social : journals.biologists.com/jcs/article/... All the supporting files you need to make your own imaging chamber are at: morgridge.org/research/lab... Happy imaging!

My amazing department Developmental and Cell Biology is hiring for a chair!! @ucirvine.bsky.social @ucibiosci.bsky.social recruit.ap.uci.edu/JPF10452

Do I know any clinical pharmacologists on here? Would you be willing to speak with a high school student? if so, please DM me or email me at chemjobber -at- gmail dot com🧪#chemsky Please RT

Big news! Our week-long #bioimageanalysis bootcamp is BACK! Learn how to think about bioimage analysis like the pros do, learn what corrections you should (and shouldn't!) apply to your images, learn open source tools, and more. Apply NOW at broad.io/BAB3 for our January 2027 course!

🚨 Our department is hiring! Looking to fill an endowed position in genetics/genomics to join us in beautiful Oregon. Search is at the Associate/Full Professor level. See below for details and share with your colleagues!

New review from the Zhang Lab in @natmethods.nature.com led by @ammgest.bsky.social ! Explore recent advances in fluorescent proteins and biosensors, including improved photostability, high-throughput screening, quantitative imaging, and multiplexing.🔬 Check it out now!👇 doi.org/10.1038/s415...

The Department of Cell Biology & Neuroscience at Rutgers is recruiting an immunologist to join us as a tenure-track Assistant Professor (due Dec 15, 2026). Come be our colleague! jobs.rutgers.edu/postings/282...

I have supported @repscottpeters.bsky.social for years, and now I have an opportunity to support @marnivonwilpert.bsky.social. My district has evolved to meet today's political needs. Her opponent has been spending county funds on advertising👇 @voiceofsandiego.org voiceofsandiego.org/2026/10/19/d...

Our multi-immersion oblique plane microscope manuscript is online now. A light-sheet system that can be adapted to different imaging tasks, including a volumetric correction for imaging in media of any refractive index. @amsikking.bsky.social www.nature.com/articles/s41...

📢 TALK ALERT: Montreal peeps! I will be giving a talk in Montreal at Hôpital Maisonneuve-Rosemont Centre de Recherche on Oct. 23 (12 to 1 pm) on on our work identifying ancient functions of two tumour suppressors: promyelocytic leukemia (PML) protein and pre-mRNA processing factor 4 kinase (PRP4K).

This reminds me of a Studio C episode from many years ago. My teenage kiddo was a Studio C fan, so this oh, so catchy jingle returned without warning from a long hiatus. This jingle may not stick like it did with the teenager, but it also brought back joyful memories. www.youtube.com/watch?v=hVr1...

Post your voting plan--when and where! I'll start. I voted yesterday during early voting in Alamance Co NC

i am currently there at the #Purdue marker. If you're in West Lafayette, come see my talk for the Biology dept tomorrow Monday, 11:30!

Udo was a very talented graduate student in my lab. She is now a postdoc in the lab of Amy Maddox at UNC Chapel Hill. Her family is dealing with unimaginable tragedy and loss and she needs our support. Please donate if you are able. Thank you. 🙏🏽 gofund.me/6a8dd8b3e

New paper by Harshath Amal @harshath.bsky.social shows how TGF-β signaling controls epithelial permeability by regulating actomyosin contractility and adhesion. Surprisingly, elevated adhesion can maintain barrier integrity independently of contractility tinyurl.com/ywenrexy @jcellsci.bsky.social

Vibes at the independent bookshop:

another week another self promotion

Proudly a FH

If you've ever wondered how the brain *really* keeps things in mind, come let Aaron, Nick & their colleagues in the Nagel lab tell you how the fly does it here: www.nature.com/articles/s41...

Bumping this up because there's still over a week to apply!

Latest paper from our lab is now out in @embojournal.org! If you want to know how 3D cell shape changes promote #woundhealing, and see a 3D vertex model that allows #scutoids to form, read this article: link.springer.com/article/10.1... Many thanks and congrats to all co-authors!

Prop. 38 in California is a scam claiming to be about funding science/medical research on major disease but is really designed to funnel billions of $$ of taxpayer money into one unnamed institution. VOTE NO ON PROP. 38. See votenoonprop38.org for more. (reposted with typo corrected)

Postdoc opening: My lab at NYU Langone Health is looking for a new postdoctoral fellow with wet-lab experience for an exciting project.

The most comprehensive data that I know isis from Grant-Witness and States United. www.lostfunds.org

Are you interested doing a Postdoc in my lab? One thing I can promise: We’ll have fun. liu.se/en/work-at-l...

These cilia in the developing quail neural tube may not be the prettiest #FluorescenceFriday image, but they’re 100% real! 🔬 No AI-generated structures, no artistic reconstruction, just real biology captured under the microscope by Murron Carroll during her Honours project in the lab. 😉

For #FluorescenceFriday - hiPSC-derived trophoblasts! Image credit to JHU Human Genetics PhD student Bailey Spiegelberg and the @lieberinstitute.bsky.social stem cell core led by @tsawada1.bsky.social

1/ Our paper, “Enhancer binding kinetics explain transcription factor hub formation,” is now published! Here we set out to understand why transcription factors form bright clusters or “hubs” in the nucleus, and whether those hubs actually control gene activity. tinyurl.com/38uf8348

New assistant professorship in predictive brain processes 🔮🧠💻 at the Department of Cognitive Neuroscience, Maastricht University. It’s a fantastic place to work and we have a vibrant interdisciplinary community. vacancies.maastrichtuniversity.nl/job/Maastric...

a fantastic new paper by lab alumni @codyz.bsky.social and yangliu9.bsky.social. Congratulations - such a cool mechanism! check it out 👇👇👇👇👇👇 www.sciencedirect.com/science/arti...

Our new Nat Plants paper introduces WALLΦ, a genetically encoded cell wall pH sensor, and reveals that root developmental zonation is independent of local cell wall pH. Wall pH supports growth at the organ level, but local growth patterns are governed by other mechanisms. doi.org/10.1038/s414...

Regaring this Press Release from yesterday. A 🧵 www.nih.gov/news-events/... I was pleased that NIH has been supporting early career investigators after Director Bhattacharya's rhetoric but lack of action last year. 1/9

Have you ever wondered how cells in developing embryos manage to squeeze through tiny spaces? And how do they cope with mechanical stresses imposed by surrounding tissues? Check out our paper, now out @natcellbio.nature.com : www.nature.com/articles/s41...