Wai-Hong Tham

We’re excited to share researchers from WEHI and global biopharmaceutical company MSD have been named finalists in the 2026 Eureka Prizes for their teamwork that has led to a new class of antimalarial treatment candidates 👏👏 Read the story: www.wehi.edu.au/news/from-la...

Very happy with this ERC Proof of Concept grant 😁. We get to test our new DENV prefusion stabilized E-dimers as immunogens. www.uu.nl/en/news/thre...

The CNRS has opened a Junior Professor Chair (CPJ) call in Parasitology, and the Microbiologie Fondamentale et Pathogénicité (MFP, Bordeaux) laboratory is among the potential host institutions. More information: www.insb.cnrs.fr/fr/cnrsinfo/... #Parasitology #Protozoology #ResearchJobs #CNRS

Nanobodies against malaria parasite adhesins that block receptor engagement and invasion Lovely work by @jaisondsa.bsky.social and Jill Chmielewski on PfRh5, PfRh4 & PvRBP2b nanobodies + stabilized PfRh4 🦙🩸⛰️ Have a read, share widely and please give us feedback! www.biorxiv.org/content/10.6...

A year before he passed away, I interviewed Dr Paul Farmer @pih.org about his book on Ebola So relevant right now, especially the dangers of “control-over-care approach” - i.e. isolation & quarantine, but fails to ensure adequate clinical care to the sick www.forbes.com/sites/madhuk...

We’re excited to welcome Lina Pinto-García @linapintogarcia.bsky.social as our special guest speaker to discuss her recent book, Maraña: War and Disease in the Jungles of Colombia. Time: Thursday 28.05.2026 , 3 PM BST Location: Zoom (Link available after registration) forms.gle/cVADyb6F5Dmh...

Registration has been reopened to fill the last few remaining spots! Last chance to join us in Leiden this June!

Eli Lilly said on Monday it would buy privately held blood cancer treatment developer Ajax Therapeutics for up to $2.3 billion in cash.

“Women today make up nearly a third of the global research workforce. But workforce representation does not automatically translate into senior or leadership positions” theconversation.com/women-in-sci...

How does HPAI affect different animals? Here airway organoids from ten diverse wildlife + livestock. host-specific differences in infection rate + patho. Useful for receptor-binding, viral dynamics, early host adaptation in poorly characterized animals 👉 www.tandfonline.com/doi/full/10....

Glycogen is ubiquitinated in vivo! And there is a clever method to detect it. It had been a privilege seeing this story come together by my colleagues in the @komanderlab.bsky.social. This will no doubt have important implications for metabolism.

Interested in non-proteinaceous ubiquitination, induced proximity or glycogen? Then you should have a look at our newest article, “Ubiquitination of glycogen and metabolites in cells and tissues”, just published in Nature: www.nature.com/articles/s41...

Calling all xray structure folks that have worked with denovo proteins. Do you suffer from high rfactors? Myself, someone else I know and now multiple structures all seem to suffer from this. Assuming we all tried our best in model building, what could be some causes?

A huge congratulations to César de la Fuente who receives the Biochemical Society Award for Significant Breakthrough or Achievement for his pioneering research into AI-driven antibiotic discovery! With AMR an increasing threat, Cesar's work paves the way for new treatments.

Congratulations to Tom Deegan who receives the Colworth Medal in 2027! Pioneering work from the Deegan Lab has redefined our understanding of eukaryotic DNA replication and provided conceptual and technical frameworks that continue to drive new discoveries across molecular biology.

We open with @sheinerlab.bsky.social introducing a scientist who needs no introduction - Dominique Soldati-Favre. Dominique was awarded lifetime membership to the @bspparasitology.bsky.social for her immeasurable contributions to the field. #bsp #parasites #peoplemakeglasgow

We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...

Host cell remodeling via cyclin dependent kinases drives Ebola virus replication and transcription. www.biorxiv.org/content/10.6... Check out our latest preprint. Great work by @tshamorkina.bsky.social. Thanks to co-authors Danni Snikkers and @hecklab.bsky.social

Wild rice is a perennial, creeping plant. The secret to its perennial growth habit lies in a developmental reversal directed by small RNAs. This image illustrates how combining perennial genes with prostrate growth genes allows cultivated rice to mimic wild rice. Learn more: https://scim.ag/40GOjDb

Very excited that the first publication from my lab is now online! Thanks to @actacrystd.iucr.org editors and reviewers for the smooth publication process. And congratulations to first author, Jiayi Pan, who completed this work in her Master’s year! @biologyanu.bsky.social

"bioRxiv is exactly the type of living experiment we all should be striving for, to achieve our shared goals of optimizing how research evidence is shared and used.” via @chrisnsimms.bsky.social www.nature.com/articles/d41...

Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor doi.org/10.1038/s415...

These HTA proteases from archaea work great for mass spec-based antibody sequencing. Paper out now in final form at Cell Systems. Congrats to @tshamorkina.bsky.social @tkadava.bsky.social @lperezpaneda.bsky.social and @hecklab.bsky.social www.sciencedirect.com/science/arti...

Congratulations to @jaisondsa.bsky.social who was awarded the JBC Herbert Tabor Early Career Investigator award from @asbmb.bsky.social 🎉 Awarded for Jaison’s PhD work on stabilized PvRBP2b variants using computational design for a better P. Vivax serological biomarker @wehi-research.bsky.social

Health and medical research is the only hope for so many health conditions, yet is chronically underfunded. Amazingly, a big part of the solution already exists. The money is literally in the bank, earmarked for health & medical research. It just has to be released. www.abc.net.au/news/2026-03...

IWD: somehow her name is less familiar, and yet, she actually received the Nobel: Dorothy Crowfoot Hodgkin: en.wikipedia.org/wiki/Dorothy...

Happy International Women’s Day #IWD2026 🤩🎉 To celebrate the day we present the first WiM sketch of the year, featuring Dr Katharine Collins, the co-inventor of the R21 malaria vaccine 👩🏻‍🔬💉

Introducing our new blood-stage malaria vaccine immunogen based on the essential invasion protein PfCyRPA. By understanding where on PfCyRPA the best antibodies bind, we used structure guided design to generate PfCyRPA-EM, which contains only the epitopes of the best antibodies.

In new study led by Brendan Larsen, we map functional constraint across the Nipah virus F protein to define constrained epitopes for antibody targeting and identify mutations that stabilize the prefusion conformation for vaccine immunogens. www.pnas.org/doi/10.1073/...

We're hiring - looking for folks with experience designing and training foundation models from scratch, particularly biomolecular language models, GNNs, or vision models. Lots of room for creativity in this role. Contact me if you have any interest

Pretty reasonable summary of the state of COVID origin debate: what most experts think (zoonosis), where information is missing (some virology lab activities), what's clearly nonsense (cold chain), what's unsupported (deliberately made) www.nature.com/articles/d41...

Come do a PhD with me and @trevor-lithgow.bsky.social at @monashuniversity.bsky.social ! We’re at the leading edge of pathogen biology using cutting edge Cryo-EM and AI-driven genetic screens to uncover the mysteries of outer membrane biology. Reach out to me for a chat! macsys.org/phd-scholars...

In 2025, GISAID cut off access to many critical SARS-CoV-2 resources, incl. our outbreak.info. A month ago, GISAID leveled accusations against us, Cov-Spectrum, Nextstrain, and members of COG-UK, which are false and misrepresent known facts. Our joint response: blog.outbreak.info/joint-respon...

The ARC have said (on LinkedIn) they will release outcomes for Discovery Projects Expressions of Interest (2027) tomorrow👇

We’re proud to welcome Prof Laura Mackay as our first Sir Gustav Nossal Professor of Immunology – advancing Sir Gus’ remarkable legacy, thanks to the generosity and vision of the Nossal family. More: www.wehi.edu.au/news/world-r...

Join us on campus & online on Friday, 6 March 2026 at 1pm for a seminar by Kate O'Hara, PhD Candidate from the Moritz Group! Details: rb.gy/u9aqza

I’ve officially started my lab at Monash University! 🎉 We’re diving into #cellgrowth and #lysosome biology, through the lens of molecular #structure and mechanism. I’m thrilled to say that PhD student scholarships are available—so please share widely and get in touch if you’re interested. 🤩

Some lovely work on the Plasmodium fertilisation machinery at #lorneiandi presented by Melanie Dietrich from the Tham Lab @thamlab.bsky.social -

Great to hear from Dr Melanie Dietrich from @thamlab.bsky.social @wehi-research.bsky.social. They found the native cryo-EM structure of Pfs230-Pfs48/45 complex, and identified domain 13 and 14 of Pfs230 as leading malaria transmission blocking vaccine candidates! 🦟 💉#lorneiandi

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

Our son, Rohan, is smiling in this photo, but make no mistake, he worked so hard to reach his goal of 100km. @scidocmartin.bsky.social & I couldn't be prouder. www.theage.com.au/national/vic... There's still time to support his fundraiser for mental health 👉 www.mycause.com.au/page/385454/...

🎉 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐓𝐡𝐞 𝐄𝐌𝐁𝐎 𝐉𝐨𝐮𝐫𝐧𝐚𝐥! After 8 months of revision, our work is now online: shorturl.at/WHmFq We uncover a previously unrecognized way that 𝑀𝑦𝑐𝑜𝑏𝑎𝑐𝑡𝑒𝑟𝑖𝑢𝑚 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 survives toxic metal stress during infection. ...

Generous international scolarships for our MSc in Epidemiology here in London. In memory of Bob May. My career is 100% resulting from something similar to this *cough* *cough* 25 *cough*.....years ago! www.imperial.ac.uk/study/fees-a...

I'm hiring! If you are a structural biology postdoc with strong cryo-EM experience who is excited about mitochondrial membrane complexes, please apply! WEHI is a great place to work with access to state-of-the art cryo-EM facilities. Apply here 👇 wehi.wd3.myworkdayjobs.com/broadbean_ex...

It's not too late to join us for Lorne I&I 2026! We have an incredible line-up of stellar Invited Speakers joining us from interstate and across the globe; check out our live Program for more details. Don't miss out, register now! www.lorneinfectionimmunity.org/registration #lorneiandi

Internationally renowned as one of the leaders in neurotransmitter transport research, don't miss Professor Renae Ryan (@renaeryan.bsky.social) present her #BiochemSoc International Award Lecture at Membrane #Proteins Conference 2026! 🧪

Really happy to see this work out! Super fun project with a great team. For me the highlight was that we finally were able to show the O-linked glycosylation systems of H. pylori/C. jejuni are general glycosylation systems which target non-flagellin proteins (suggest >10 years ago by click chem).

Been on multiple search committees For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read

Have I ever mentioned how surreal it is to be an Editor-in-Chief of a journal called Vaccine right now? www.science.org/content/arti... It’s pretty wild, at least by typical academic journal editorial office standards.