Teresa Rayon

Teresa Rayon

@trayon.bsky.social

Developmental biologist. EvoDevo & comparative stem cell dynamics 🐭⌛️👤⏳. Group Leader @babrahaminst.bsky.social. @sebioldev.bsky.social board member. @bsdb.bsky.social committee member.

1.6K followers728 following145 posts

Teresa Rayon reposted

SEBD
@sebioldev.bsky.social

Excited to welcome @joadelas.bsky.social to #SEBD2026 Her lab @ucl.ac.uk investigates the #epigenetic mechanisms that guide stem cell fate and neural development. Her research focuses on how #genomic regions and epigenetic regulators control cell differentiation during mammalian #development #devbio

Teresa Rayon
@trayon.bsky.social

Exciting opportunity to lead @babrahaminst.bsky.social’s proteomics facility! Our lab will collaborate on low-input proteomics, SILAC, maximizing the potential of the new Astral mass spectrometer. 🔁 Please share with anyone who might be interested! babraham.current-vacancies.com/Jobs/Advert/...

babraham.current-vacancies.comHead of Mass Spectrometry Facility - Babraham Institute, CambridgeWe are seeking an ambitious and scientifically accomplished proteomics specialist to lead the Babraham Institutes Mass Spectrometry Facility during an exciting period of growth and investment. This i...

Teresa Rayon reposted

Simon Cook
@drsimoncook.bsky.social

Looking for a change? Is this your Time-of-flight? @babrahaminst.bsky.social are seeking an ambitious and scientifically accomplished proteomics specialist to lead our Mass Spectrometry Facility during an exciting period of growth. Come and join us! babraham.current-vacancies.com/Jobs/Advert/...

babraham.current-vacancies.comHead of Mass Spectrometry Facility - Babraham Institute, CambridgeWe are seeking an ambitious and scientifically accomplished proteomics specialist to lead the Babraham Institutes Mass Spectrometry Facility during an exciting period of growth and investment. This i...
Teresa Rayon
@trayon.bsky.social

Congrats Marta 🏆🏆

SEBD@sebioldev.bsky.social

📹 Entrevistamos a @marta-shahbazi.bsky.social la ganadora del premio José Luis Gomez-Skarmeta 2026 #JLGS2026 para saber más sobre lo que hacen en su laboratorio y lo que le motiva a investigar en Biologia del Desarrollo #BioDes Miralo aquí 👇🏻 youtu.be/3OtddcY8Cko

youtu.beMarta Shahbazi. Premio SEBD José Luis Gómez-Skarmeta (JLGS) 2026YouTube video by Sociedad Española de Biología del Desarrollo
Teresa Rayon
@trayon.bsky.social

‼️ Postdoc position open. We study how protein metabolism controls time. If you’re excited by this question, we’d love to hear from you! We’re looking for a motivated & collaborative researcher with a strong track record. 📅 30 September 2026 📢 Please share Apply here 👇👇

babraham.current-vacancies.comPostdoctoral Research Scientist - BabrahamThe lab investigates the molecular mechanisms that control biological timing in mouse and human stem cells (Azzi & Rayon, Curr Opinions 2024; Nakanoh et al., Dev Cell 2026). The central aim of this ex...

Teresa Rayon reposted

Ruben Perez-Carrasco
@perez-carrasco.bsky.social

The new AC-DC paper is out! ⚡ One small gene circuit, more than 30 distinct dynamical behaviours. Showing how small regulatory networks can hide a surprising amount of dynamical complexity. www.cell.com/cell-systems...

cell.comLet there be multifunctionality: Uncovering the dynamical zoo of the AC-DC genetic circuitSmall gene regulatory circuits can encode a surprising diversity of dynamical behaviors. A biophysical model of the AC-DC motif reveals over thirty distinct bifurcation structures and shows how molecu...
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Teresa Rayon
@trayon.bsky.social

-Both studies show causal evidence -This regulatory mode differs from a transcription-centric mechanism & highlights the emerging roles of metabolism and proteostasis in developmental regulation. - Notably, PROTACs may enable regulatory networks to be dissected with high kinetic resolution. 🔥🔥🔥

Teresa Rayon
@trayon.bsky.social

Join us @ #EMBOomics to hear about research that builds mechanistic models to understand & ultimately engineer cellular behaviour 🦄 Incredible line-up of speakers from genomics, proteomics, imaging, single-cell, synthetic biology & theory. Abstract submission closes 11 Sept 👇👇

EMBL Events@events.embl.org

You only have until 11 Sep to submit your abstract for #EMBOomics! ➡️ s.embl.org/omx26-01-bl Join us to discuss the latest developments in the field with leaders in genomics, dynamic proteomics, quantitative imaging, and synthetic biology.

Teresa Rayon reposted

James Briscoe
@jamesbriscoe.bsky.social

Towards a probabilistic view of cardiac lineage allocation @kenzoivanovitch.bsky.social reframes the question of heart development as stochastic in which epiblast cells have probability distributions of fates that resolve during gastrulation onlinelibrary.wiley.com/doi/10.1002/...

onlinelibrary.wiley.comBeyond Binary: Cardiac Patterning as Probabilistic Fate RestrictionAre cardiac progenitors committed to fixed lineages, or do they carry probability distributions over heart regions in the epiblast that resolve during gastrulation? Reanalyzing mouse retrospective cl...
Teresa Rayon
@trayon.bsky.social

Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation

Developmental Cell@cp-devcell.bsky.social

Online now: Proteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitors #biology #science

dlvr.itProteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitorsWhy do mammalian species develop at different speeds? Nakanoh, Stamataki, et al. show that mouse neural progenitors have faster protein synthesis and proteasome-mediated degradation than human. Manipulating proteasome activity alters the pace of neural development, implicating protein turnover in the evolution of developmental tempo.
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Teresa Rayon
@trayon.bsky.social

@ebisuyamiki.bsky.social @savitski-lab.bsky.social show slower protein degradation in human presomitic mesoderm cells than in mouse, and that 2DG perturbations affect protein stability & dev. tempo A pleasure to coordinate our submissions with this great work & share these complementary findings!

authors.elsevier.comSystematic differences in protein stability underlie species-specific developmental tempoHuman embryonic development proceeds more slowly than in mice. The segmentation clock offers a tractable model for studying species-specific developme…
Teresa Rayon
@trayon.bsky.social

Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation

Developmental Cell@cp-devcell.bsky.social

Online now: Proteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitors #biology #science

dlvr.itProteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitorsWhy do mammalian species develop at different speeds? Nakanoh, Stamataki, et al. show that mouse neural progenitors have faster protein synthesis and proteasome-mediated degradation than human. Manipulating proteasome activity alters the pace of neural development, implicating protein turnover in the evolution of developmental tempo.
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Teresa Rayon
@trayon.bsky.social

Perturbations that reduce proteasomal activity in mice or increase proteasomal activity in humans affect developmental tempo, thereby providing a causal link. Thus, active protein degradation is a key determinant of developmental tempo.

Teresa Rayon
@trayon.bsky.social

Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation

Developmental Cell@cp-devcell.bsky.social

Online now: Proteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitors #biology #science

dlvr.itProteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitorsWhy do mammalian species develop at different speeds? Nakanoh, Stamataki, et al. show that mouse neural progenitors have faster protein synthesis and proteasome-mediated degradation than human. Manipulating proteasome activity alters the pace of neural development, implicating protein turnover in the evolution of developmental tempo.
View full thread
Teresa Rayon
@trayon.bsky.social

Protein half-lives are also shorter in mouse NPs than in human NPs, revealing faster degradation of orthologous proteins irrespective of function, abundance, size, or cellular compartment

Teresa Rayon
@trayon.bsky.social

Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation

Developmental Cell@cp-devcell.bsky.social

Online now: Proteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitors #biology #science

dlvr.itProteasome-dependent protein degradation shapes developmental tempo in mouse and human neural progenitorsWhy do mammalian species develop at different speeds? Nakanoh, Stamataki, et al. show that mouse neural progenitors have faster protein synthesis and proteasome-mediated degradation than human. Manipulating proteasome activity alters the pace of neural development, implicating protein turnover in the evolution of developmental tempo.
Teresa Rayon
@trayon.bsky.social

🔥💣 rewirement of hiPSCs towards “anterior epiblast” restores differentiation capacity 🔥💣 Congrats to both teams!!!

Stefan Schoenfelder@stefanschoenfelder.bsky.social

Very happy to see this story finally out in @natbiotech.nature.com: www.nature.com/articles/s41... Fantastic collaboration with @lancasterlab.bsky.social on how to identify and ‘fix’ differentiation-compromised human pluripotent stem cells. @babrahaminst.bsky.social @mrclmb.ac.uk 🧵 below

nature.comReversible epiblast regionalization determines differentiation potential of human pluripotent stem cells - Nature BiotechnologyThe differentiation variability of human pluripotent stem cell lines is diagnosed and corrected.
Teresa Rayon
@trayon.bsky.social

A thoughtful piece on what it means to be a postdoc: *independence is about moving forward without all answers *use science conversations to make sense of uncertainty, beyond presenting results *a postdoc is as much about learning to think & adapt as it is about generating data & publishing

eLife@elife.bsky.social

A postdoc comes with challenges and uncertainties different from those of a PhD. In this ecrLife blog Vartika Sharma shares how managing expectations and building a community are key skills that can help us navigate the new uncertainties of a postdoc.

buff.lyThe Invisible Skills of a Postdoc: What No One Formally TeachesA postdoc comes with challenges and uncertainties that are different from those of a PhD. Here, Vartika Sharma shares how managing expectations and building a community are key skills that can help…
Teresa Rayon
@trayon.bsky.social

🐙 Octopuses appear to have evolved a ribosomal innovation that increases protein translation fidelity. *suggests that evolution can tune core components of the proteostasis machinery, extending adaptation beyond gene regulation www.biorxiv.org/content/10.6...

biorxiv.orgEvolution of a core ribosomal innovation in octopusMuch of biology focuses on how genetic changes mediate new functions, but less attention is given to adaptations in other steps of the central dogma. Octopuses exhibit complex nervous systems and soph...

Teresa Rayon reposted

Vicki Metzis
@vmetzis.bsky.social

How does an embryo generate the right cells in the right place? Delighted to share our latest findings on how neural crest cells acquire vagal or trunk identities Spoiler alert: The timing & combination of CDXs preconfigures cell identity & distinct HOX states www.biorxiv.org/content/10.6...

biorxiv.orgTemporally distinct CDX programmes preconfigure vagal and trunk neural crestNeural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie...
Teresa Rayon
@trayon.bsky.social

In case you missed this preprint - check it out now! Determining Species-specific tempo per cell between fishes 🐟 ⌛️ 🐠 ⏳ Congrats to Jess, Mike et al!

Mike Dorrity@mwdorr.bsky.social

First pre-print from the lab, a collaborative effort led by Jess Bourn @bournsupremacy.bsky.social, a fantastic PhD in my group. We resolve a key problem in development + evolution: how do we quantify heterochrony and link temporal variation to phenotype? www.biorxiv.org/content/10.6...

biorxiv.orgQuantitative mapping of heterochrony to species-specific phenotypesThe genetic program of animal development is conserved, but its rate of execution varies across species. Heterochrony, shifts in the relative timing of developmental events, generates phenotypic varia...

Teresa Rayon reposted

Sergio Menchero
@sermenchero.bsky.social

The 2nd part of my postdoc is now out as a preprint! A challenging but fulfilling team effort to perform genome editing in opossums. We found that the lncRNA RSX is essential to initiate X-inactivation in marsupials 🦘 A long-standing question since the discovery that Xist is absent in marsupials 👇

Turner Lab@lab-turner.bsky.social

New preprint 📢 Thrilled to share our long-awaited work on the role of RSX in marsupial X-inactivation. This was a huge team effort over the years, led by @aureliencourtois.bsky.social @sermenchero.bsky.social Sugako Ogushi and Waz Varsally, that allowed us to set up genome editing in opossum embryos

biorxiv.orgGenome editing of marsupial RSX reveals conserved and divergent principles in mammalian X-inactivationX-chromosome inactivation balances X-gene dosage between the sexes in eutherians and marsupials. The lncRNA Xist mediates X-inactivation in eutherians but is absent from marsupials. An evolutionarily ...

Teresa Rayon reposted

James Briscoe
@jamesbriscoe.bsky.social

Paying peer reviewers Interview with @danielgorelick.bsky.social about @biologyopen.bsky.social Fast & Fair trial in which peer reviewers were paid £220/review Spoiler: it works - fast, high quality reviews www.nature.com/articles/d41...

nature.comWhy paying peer reviewers works, according to a journal’s editor-in-chiefA biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.
Teresa Rayon
@trayon.bsky.social

AI ranking shows familiar cracks: figure vs text evaluation, the Matthew effect & male last author bias Celebratory signals for visibility are already popping up too. This experiment feels like an emerging curation space *we need to shape and exploit AI systems beyond simple approval loops

QED Science@qedscience.bsky.social

🎉 Meet The 1%. Out of 57,455 bioRxiv life science preprints, QED Science selected 574 exceptional manuscripts through blind evaluation. The 1%: the-one-percent.qedscience.com Good science deserves to be seen. @biorxivpreprint.bsky.social @openrxiv.bsky.social @richardsever.bsky.social

Teresa Rayon
@trayon.bsky.social

Congrats Elisa!! 🍾 💡🧪 An innovative study using human stem cell-derived spinal cord organoids to explore neural tube morphogenesis, patterning, and function. A strong example of the originality & excellence of #DevBio research in Spain.

SEBD@sebioldev.bsky.social

Today we congratulate #SEBD member Elisa Marti @ibmb-csic.bsky.social for being one of this year’s awardees of the ERC advanced grants! With her project SpinaLogic her research group aims to unravel the direct conection between the genetic mutations associated with Spina bifida (1/2)

Teresa Rayon reposted

Benjamin Swedlund
@benswedlund.bsky.social

Beautiful piece on how field-specific journals with high ethical standards, such as Development, don’t try to « Game » the impact factor system - and practical steps to move away from this inherently flawed metric as a researcher (see Box 2)

James Briscoe@jamesbriscoe.bsky.social

As Editor of @dev-journal.bsky.social I get asked "What are you doing about your impact factor?" In our new editorial we say: Ask not what Dev can do for the impact factor. Ask what you can do for Dev's IF The IF is about how we all cite, review & assess each other's work doi.org/10.1242/dev....

doi.orgThe elephant in the room: impact factorSummary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...
Teresa Rayon
@trayon.bsky.social

Looking forward to presenting our work and to all the exciting discussions about embryo development today!

bedzhov lab@bedzhovlab.bsky.social

“Play, Pause, Rewind: protein metabolism and the control of developmental tempo” Looking forward to an exciting seminar with Teresa Rayon @trayon.bsky.social (Babraham Institute, Cambridge) on June 18th at 13:15, MiC. Everyone is welcome.

Teresa Rayon
@trayon.bsky.social

Excited that Ellie presented her PhD project @yen-network.bsky.social 2026 in front of friends and colleagues Well done & congrats 🎉🎈🍾🎊 @bsdb.bsky.social @babrahaminst.bsky.social #devbio 🧪

Joaquina Delas@joadelas.bsky.social

Great back-to-back short talks by Shayma and Eleanor PhD students in the labs of my former postdoc colleagues @kenzoivanovitch.bsky.social and @trayon.bsky.social So special to see their trainees shine! #YEN2026 @yen-network.bsky.social

Teresa Rayon
@trayon.bsky.social

A UK node for microscopists to work together and combine their expertise in a distributed Node setup. Congrats 🎊🍾🎉 @babrahaminst.bsky.social @smonw.bsky.social #eurobioimaging

Simon Cook@drsimoncook.bsky.social

A ringing endorsement for @smonw.bsky.social and his excellent Imaging Team @babrahaminst.bsky.social www.linkedin.com/posts/hoyled...

linkedin.com#eurobioimaging | Danielle HoyleWe are pleased to share the news that our Imaging Facility - lead by Simon Walker - is now part of the UK Node of the #EuroBioImaging network. Our unique offering provides researchers with access to c...

Teresa Rayon reposted

Ali Seleit
@aliseleit.bsky.social

The complete bureaucratization and corporatization (dare I say entshitification) of higher education. Trend called many years ago by the incredibly prescient David Graeber.

Michael Hothorn@structplantbio.bsky.social

This work nicely quantifies a major issue in our universities: "In higher education, administrative costs have risen much faster than instruction and research costs (4). MIT Faculty grew by only 9.2% between 1985 and 2023, while administrative staff grew by 189%." www.pnas.org/doi/10.1073/...

Teresa Rayon
@trayon.bsky.social

In vivo research = biological function. *Contributes to developing, validating & promoting cell-based models now shaping policy discussions. *adopts emerging technologies: gene base editing, environmental perturbation, spatial biology journals.biologists.com/dmm/article/...

journals.biologists.comWhy in vivo models of disease remain indispensableSummary: The call to arms for alternatives to model organisms of disease will fail without ongoing integration with – and validation against – complex animal models and support from the animal modelli...