Barral Lab

Barral Lab

@barrallab.bsky.social

Immunology lab at King’s College London and The Francis Crick Institute #Immunology #Lipids #NKT #MAIT

1.4K followers1.7K following10 posts

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Barral Lab
@barrallab.bsky.social

Our latest paper is out! We went back to our favourite molecule, CD1d, and explored its functions in myeloid cells in tumours. Amazing work from Lauren and Maria, and many thanks to our collaborators and funders @breastcancernow.bsky.social @cruk-cityoflondon.bsky.social doi.org/10.1084/jem....

doi.orgCD1d remodels the tumor-infiltrating myeloid populations controlling antitumor immunityEvans et al. identify CD1d as a key regulator of myeloid cell diversity in breast cancer. CD1d targeting reshapes tumor immune infiltrates, suppresses tumo

Barral Lab reposted

Reese Richardson
@reeserichardson.bsky.social

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

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Juan Martin Serrano
@juanmartin-serrano.bsky.social

Very proud to see this paper out. This is an incredible collaboration with the labs of Wes Sundquist and Adam Frost. @uofubiochem.bsky.social @kingslsm.bsky.social www.nature.com/articles/s41...

nature.comESCRT-III assembles around mis-segregated DNA to protect genome stability - Nature Structural & Molecular BiologyThe authors show that persistent ultrafine DNA bridges become coated by membranes and the ESCRT-III proteins CHMP1B and IST1, which protect the genome within from damage.

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Thiago Carvalho
@cyrilpedia.bsky.social

They always do 'Merck’s remigromig could become the first trispecific to market. Its origins date back, however, to an academic exploration of antibody space that started before bispecifics had hit the market.' www.nature.com/articles/d41...

nature.comCan multispecific biologics break the efficacy ceiling?A growing pipeline of multispecific antibody therapies are in clinical trials, showcasing novel biological effects as well as potential improvements over multi-agent cocktails.

Barral Lab reposted

Prof Gavin Yamey MD MPH
@gavinyamey.bsky.social

Wow 😧 “Members of the American Diabetes Association (ADA) were escorted by police out of the convention center in New Orleans during the organization's annual meeting on Friday as they handed out copies of an editorial criticizing Trump administration changes to U.S. biomedical research.”

Edward Nirenberg@enirenberg.bsky.social

Can we please return to precedented times? I wish to be bored again by the news.

medpagetoday.comVideo: Police Tussle With Diabetes Experts at ADA MeetingResearchers told they could no longer attend the annual scientific sessions

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Carl T. Bergstrom
@carlbergstrom.com

The criticism of Trump, Kennedy, and Bhattacharya that was so subversive that the ADA had to eject the Editor-in-Chief of their flagship journal from their annual meeting for sharing it? Prior today it had fewer than 1000 views. Do your thing.

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Dr. Lucky Tran
@luckytran.com

Incredible! Scientists receive a rare standing ovation after announcing that a new treatment can double the survival time for pancreatic cancer, the deadliest cancer which was once considered “undruggable.” When we fund and support science, we can achieve anything! (Video: Dr. Wish Dhillon)

Barral Lab reposted

ana-farias.bsky.social
@ana-farias.bsky.social

Very pleased to see my postdoc work studying respiratory viral infections and lung metastasis published in @pnas.org! Many thanks to @cjohansson-lab.bsky.social and @ila07.bsky.social labs at @imperialnhli.bsky.social and @crick.ac.uk! www.pnas.org/doi/10.1073/...

pnas.orgType I interferons induced upon respiratory viral infection impair lung metastatic initiation | PNASMetastatic breast cancer accounts for 7% of cancer-related deaths, with the lungs being a common site of cancer spread. In parallel, lower respirat...

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Institut Pasteur | 130 years of biomedical research
@pasteur.fr

Institut Pasteur mourns the passing of Philippe Bousso, a renowned immunologist, head of the Dynamics of Immune Responses unit and director of the Immunology Department. His pioneering imaging work transformed our understanding of immune cells in vivo. 1/3

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Cecilia Johansson
@cjohansson-lab.bsky.social

Very pleased to share our collaborative work with Ilaria Malanchi's lab. We have combined our lab's specialities and studied respiratory viral infections, type I IFNs and metastatic cancer spread to the lung. www.pnas.org/doi/10.1073/... @ila07.bsky.social @imperialnhli.bsky.social

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Jan Rosenow
@janrosenow.bsky.social

Spain's renewables build-out has structurally decoupled its electricity prices from gas markets. Gas now sets the price in only 15% of hours, compared to 90% in Italy. Countries that invested early in clean power are far less exposed to fossil fuel price shocks. Those that didn't now pay the price.

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Edward Nirenberg
@enirenberg.bsky.social

It's crazy to me how the papers that get published today could easily have been 3 or 4 papers even a decade or two ago. The amount of information they are saturated with is intense.

Barral Lab reposted

Stefan Marciniak
@profmarciniak.bsky.social

“The gender pay gap, which stands at £2,548 a year, means that women have effectively worked for free so far this year, the TUC said” This is a stain on the country Ask yourself, are your mother, sister, daughter, wife less valuable than their male colleagues?

The Guardian@theguardian.com

UK’s gender pay gap forecast to persist for another 30 years

theguardian.comUK’s gender pay gap forecast to persist for another 30 yearsTrades Union Congress says women have effectively been working for free this year and legislation is needed Women in the UK will not be paid the same as men until 2056 at the current rate of progress, according to a Trades Union Congress report. The gender pay gap, which stands at £2,548 a year, means that women have effectively worked for free so far this year, the TUC said. Continue reading...

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Christian Zierhut
@zierlab.bsky.social

This is an absolute outrage that should be discussed as widely as possible. I expect that this failing government will try and use the MRC to divert funding from academic research into commercial enterprises, killing UK research in the process.

Mark A. Hanson@hansonmark.bsky.social

Both MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate). Listen, I get that UKRI wants to pivot. But killing both at once is devastating. Let's hope at least one opens by summer... #AcademicSky

researchprofessionalnews.comMRC instructs grant review boards to slash funding rates - Research Professional NewsBoards asked to recommend just three applications for funding, as BBSRC also suspends calls

Barral Lab reposted

Mark A. Hanson
@hansonmark.bsky.social

Both MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate). Listen, I get that UKRI wants to pivot. But killing both at once is devastating. Let's hope at least one opens by summer... #AcademicSky

researchprofessionalnews.comMRC instructs grant review boards to slash funding rates - Research Professional NewsBoards asked to recommend just three applications for funding, as BBSRC also suspends calls

Barral Lab reposted

Alan McNally
@alanmcn1.bsky.social

I am sorry. We all knew the three buckets were coming. We are all prepared for a shift in priority. But this message does nothing for all the UK scientists dependent on project grant funding. It doesn’t actually give any information www.ukri.org/news/open-le...

ukri.orgOpen letter from Ian Chapman to research and innovation communityUKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.

Barral Lab reposted

Willem van Schaik
@wvschaik.bsky.social

Update on UKRI funding situation. Summary: it is mostly bad news, and with significant uncertainties around new funding model.

Research Professional News@resprofnews.bsky.social

‘Grave’ concerns over applicant-led funds at UK research councils. www.researchprofessionalnews.com/rr-news-uk-r...

Barral Lab reposted

Margot Finn
@eicathomefinn.bsky.social

'Despite all their difficulties, universities remain an enormous and irreplaceable national asset. As well as educating millions of people, they generate about £24bn in export earnings, which is about 1% of GDP – more than aircraft manufacturing and legal services combined'. 1/2

theguardian.comThe Guardian view on universities: Labour needs a clearer plan | EditorialEditorial: Ministers promised a ‘change of approach’, but their new tax could tip weaker institutions over the edge

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Caetano Reis e Sousa
@reisesousalab.bsky.social

Taking advantage of a natural experiment, this follow-up by @pascalge.bsky.social of their earlier study in Nature on the beneficial effects of shingles vacination on dementia. Very cool stuff! www.cell.com/cell/fulltex...

cell.comThe effect of shingles vaccination at different stages of the dementia disease courseA natural experiment found that herpes zoster vaccination reduced the occurrence of mild cognitive impairment and deaths due to dementia, indicating that the vaccine may slow the progression of dement...

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ImmuNoah's Ark (Noe Rodriguez)
@immunoah.bsky.social

We need to apply @nc3rs.bsky.social principles, ensure animal welfare & do the best possible by research animals. But let's not confuse people or ourselves by thinking they're dispensable. Why we have to continue with animal testing for medical research | Letters www.theguardian.com/science/2025...

theguardian.comWhy we have to continue with animal testing for medical research | LettersLetters: Dr Robin Lovell-Badge and Prof Emma Robinson respond to an editorial on using new technologies to reduce the reliance on animal experiments

Barral Lab reposted

Rita Strack
@ritastrack.bsky.social

Today is the International day for the elimination of violence against women. In 2024, an estimated 50,000 women and girls were killed by intimate partners or family members worldwide. That is 137 women and girls every day. One every ten minutes. www.un.org/en/observanc...

un.orgInternational Day for the Elimination of Violence against Women | United NationsThe International Day for the Elimination of Violence against Women aims to create awareness of the fact that violence against women is a human rights violation that impedes progress in many areas, in...

Barral Lab reposted

Doctors Without Borders / Médecins Sans Frontières (MSF)
@msf.ca

#Sudan: We call on the RSF to protect health facilities and staff, following the death of a Ministry of Health colleague during a shooting at Zalingei hospital. For the second time this year, we have withdrawn staff to ensure their safety. ow.ly/O8VW50XxNcx

ow.lySudan: MSF calls for protection of health facilities and staff after health worker killed | Doctors Without Borders / Médecins Sans Frontières (MSF ...MSF calls for protection of health workers and facilities after a colleague was killed at Zalingei Hospital in Central Darfur, disrupting care.