Sarah Cobey

Sarah Cobey

@cobey.bsky.social

Professor at U. Chicago. Computational epidemiology, evolution, influenza, SARS-CoV-2, vaccines, and B cells. Infectious disease dynamics across scales.

4K followers767 following99 posts

Sarah Cobey reposted

Here’s something you should know about minks: They have lungs and airways remarkably similar on a cellular level to those of people. They’ve spread flus and infected humans before with COVID-19. Right now, bird flu is spreading on a Utah farm filled with thousands of them… 🧵

“The lack of action… can also, in turn, increase gendered service burdens, as women take on more work to try to improve their workplace climates.” Most senior women faculty I know regularly help colleagues at other institutions, too. It adds up.

Katie Spoon@kspoon.bsky.social

As a PhD student designing my first survey, I added what I thought was a throwaway question at the end. To my surprise, thousands of academics answered it! The paper is out today: doi.org/10.1093/pnas...

Sarah Cobey reposted

Sarah Cobey reposted

The NIH proposal to conceal reviewer scores from program officers, investigators, and advisory councils is ill-conceived, introduces disproportionate weight to small percentile differences, diminishes the role of scientific peer review, and should be withdrawn in its entirety. a 🧵

joshuasweitz.substack.comWhat is NIH Leadership Trying to Hide from Researchers & the Public?A NIH proposal to conceal reviewer rankings of investigator-initiated research grants is ripe for misuse & demands a collective response (by October 13).

Sarah Cobey reposted

Replying to @philippmarkolin.eurosky.social

I do find it stunning, for all of the NYT's criticism of postmodern constructivism and "woke" ideology, that most of their editorialising signals a deep nihilism towards empirical reality, where science is just annother perspective, and voter polls decide what's moral or political reality.

Sarah Cobey reposted

Replying to @vincentholst.bsky.social

Instead of a decline in the disruptiveness of scientific and technological knowledge, the data mainly show an increasing metadata quality over time: relatively fewer papers with zero references due to database errors. 7/8

Sarah Cobey reposted

Science is a global pursuit. This undermines our leadership in science. And it harms young scientists trying to start their careers here.

This post is unavailable.

I know it’s hard to decide which battle to fight some days. Pick this one.

Mark Peifer (He, him)@peiferlabunc.bsky.social

Russell Vought, Director of the OMB, has issued a set of proposed changes that would dramatically alter federal grant funding. However, we can each take action to prevent these from taking effect. Here's how, a 🧵 🧪 1/n www.science.org/content/arti...

Sarah Cobey reposted

Replying to @katymilkman.bsky.social

🧪Totally disingenuous. The question is not whether the speakers you chose are popular or unpopular. The question is whether or not they are qualified. And an administrator cutting science for political purposes and suppressing scientific studies is not "advocating for scientific reforms".

Sarah Cobey reposted

“It was Barry who discovered that lymphocytes-not macrophages, as some hypothesized-that carry immune memory. showed that lymphocytes signal to macrophages through a chemical they termed MIF-which, together w/ interferon, were the 1st cytokines discovered” www.statnews.com/2026/03/30/b...

statnews.comRemembering public health pioneer Barry Bloom: a scientist, a mentor, a menschMarc Lipsitch and Yonatan Grad pay tribute to their former colleague and mentor Barry R. Bloom.

Sarah Cobey reposted

The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.

Dr. Bhattacharya recently came to U. Chicago for an "off the record" event. My strong impression was that he is truly unfamiliar with how most biomedical research works.

Jeremy Berg@jeremymberg.bsky.social

A second email, this with a more substantial insight about "The Replication Crisis"... 1/5

Sarah Cobey reposted

Replying to @jdmunday.bsky.social

We found that while close contact contributed to elevated risk (rate ratio 1.16 per doubling daily time, 95%-CI 1.01–1.33), time spent in shared classrooms and poor air quality had larger effects (RR 3.17, 95%-CI 1.96–5.17 and RR 1.90 95%-CI 1.23–2.94) respectively).

Sarah Cobey reposted

Replying to @maxkozlov.bsky.social

This is a targeted attack on science media. Bhattacharya has slammed science media for what he calls biased coverage, but how are our readers — the global scientific community — supposed to understand his new agency priorities if we can't even get in the door?

Sarah Cobey reposted

Just spoke to The Hill about how the dismantling of the NIH is impacting science in America. We still face a cliff of unfathomable heights, w easily 1000+ labs poised to close in the next year due to funding ending. A generation of young scientists lost because there is nowhere for them to train.

Sarah Cobey reposted

Replying to @joshuasweitz.bsky.social

Yes, we have a problem. The problem starts at the top. The problem is worsened by leadership of @nature.com & other journals & professional organizations who think that power demands a platform without scrutiny.

Sarah Cobey reposted

A bad thing is unfolding at NIH this week: It looks like the Trump administration is trying to replace key civil servant scientific leaders, the Institute Directors, with political hires. These directors control the NIH budget, tens of billions. A bit of a video explainer here: 1/ 🧪

It was surreal to be quizzed on “freedom of inquiry” and other values in my mandated U. Chicago/NIH/NSF research security training tonight given the restrictions to our research over the past eight months. Jeremy describes the experience perfectly below. (His piece is outstanding.)

Jeremy Berg@jeremymberg.bsky.social

6/14

Sarah Cobey reposted

Immigrants, particularly on H1Bs, are the lifeblood of American innovation. If you wanted to hurt US competitiveness in the next century, I can think of few more effective ways than a move like this Even when found illegal, the mere intent will have irreparably harmed our future

Sarah Cobey reposted

Replying to @wcratcliff.bsky.social

But it does not *want* to do that. It has the personality and confidence of a 10x coder, and *absolutely lies to your face* to maintain the illusion. It races to establish huge frameworks, call up parallel agents, and build you something that gives an output.

Sarah Cobey reposted

Just few days left to apply to one of these postdoc positions in my infectious disease modelling Unit at @pasteur.fr in Paris!

Simon Cauchemez@scauchemez.bsky.social

New postdoc positions with a number of exciting epidemic modelling projects opening in our Unit at @pasteur.fr in beautiful Paris. Deadline for applications: 26th June. research.pasteur.fr/en/job/postd...

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Overall, quantifying pathogen resilience offers a new perspective on understanding how pathogens respond to both large and small perturbations. These insights have important implications for pathogen persistence, prediction, and model validation. [7/8]

Coauthors are Bjarke Nielsen, Emily Howerton, and Bryan Grenfell. This work was mostly funded by the Life Sciences Research Foundation and NIH. Daniel is no longer on social media but is happy to answer any questions. [8/8]

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What determines how resilient a pathogen is? It depends on the per-capita rate of replenishment of the susceptible population. Faster replenishment = more resilient dynamics, where the rate of replenishment depends on the duration of immunity and basic reproduction number (R0). [5/8]

We've focused on resilience in the context of large perturbations. We also showed that resilience determines how sensitive a system is to smaller stochastic perturbations, with less resilient systems exhibiting greater deviations from deterministic trajectories under demographic stochasticity. [6/8]

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We analyzed relevant time series data from Hong Kong, Canada, Korea, and the US. By quantifying the resilience of common respiratory pathogens, we could predict when each pathogen would eventually return to its pre-pandemic dynamics. [3/8]

We estimated that common respiratory pathogens are much more resilient than vaccine-preventable infections, such as measles. Our predictions about pathogen return also closely match the observed deviations (or lack thereof) from the pre-COVID dynamics of respiratory pathogens. [4/8]

COVID-19 interventions disrupted the circulation of many pathogens. To understand if and when they might return to pre-pandemic patterns, we developed a framework for quantifying the rate of return to pre-pandemic patterns—a measure of pathogen resilience in a given host population. [2/8]

Sarah Cobey reposted

🧪 You can sign a supporting letter in solidarity with the NIH scientists here: www.standupforscience.net/bethesda-dec...

standupforscience.netBethesda Declaration — STAND UP FOR SCIENCESupport NIH Staff Now!
Alt NIH Bluesky 🧪@altnih4science.bsky.social

“We urge you as NIH Director to restore grants delayed or terminated for political reasons so that life-saving science can continue.” Over one hundred NIH employees publish a letter of dissent to Trump administration attacks on medical research, the “Bethesda Declaration.” 🧪

Sarah Cobey reposted

How bad will it be? Catastrophic. Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come. But, this is the WH's *proposed* budget. Speak up now before it is too late. (inflation adjusted $-s below)

Sarah Cobey reposted

A not very happy Friday. CERI had 6 NIH grants canceled, which will impact operations, surveillance and response to epidemics. We are working to try to minimize disturbance but not easy with 6 grants terminated at the same moment. A crisis is unfolding in SA www.news24.com/southafrica/...

news24.comSA universities face funding crisis as US federal agencies freeze research grants | News24An investigation into the impact of the US aid freeze on research funding to South African universities has found that 44 programmes worth R2.5 billion were affected.

Sarah Cobey reposted

I was working on a proposal in response to one of these calls. Submission deadline next week. The proposal was 95% done, and I only learned about the cancellation from this post. 🤷‍♂️

Gabi Serrato Marks@gserratomarks.bsky.social

NIH moved up the expiration date for some funding opportunities, effectively *canceling* the next application date without removing it from the standard table. I can't even imagine how many people are still prepping these grants. 👀 List of impacted opportunities: grants.nih.gov/grants/guide...

Sarah Cobey reposted

Replying to @alicele.bsky.social

Yes, that’s exactly what they are doing. They are trying to hurt Harvard by destroying my research

Sarah Cobey reposted

Replying to @adamjkucharski.bsky.social

But it seems disingenuous to bluntly and severely penalise researchers (and with zero advance notice) for focusing on issues that you’ve built your own career on.

I received a surprising and disturbing request from NIH on Friday. They wrote to cancel a subaward to Hong Kong on one of my grants. (This was disturbing but not surprising.) They also ordered us not to interact with our collaborators in Hong Kong on any work under the award:

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The NIH’s withdrawal of funding for collaborations with the best scientists in other countries severely damages U.S. research. Forbidding U.S. scientists from even *interacting* with foreign talent when trying to solve research problems is insane.

Important detail: This prohibition on interacting with Hong Kong researchers under the award would seem to apply to our collaborators in Paris too. This doesn’t just affect scientists in the U.S. and Hong Kong.

I received a surprising and disturbing request from NIH on Friday. They wrote to cancel a subaward to Hong Kong on one of my grants. (This was disturbing but not surprising.) They also ordered us not to interact with our collaborators in Hong Kong on any work under the award:

View full thread

I worry if I will be allowed to interact with them on any of our funded work, or if I will need to drop NIH funding to do so. For current grants, will we be allowed to publish our shared findings? What about IRB protocols involving secondary use of data from HK? Is all our HK-related work a loss?

Hong Kong and China are not the only targets. The leaked NIH memo* from March also calls out S Africa and other countries of concern. If you follow infectious disease research, you know S Africa is another powerhouse. *https://media.nature.com/original/magazine-assets/d41586-025-00954-y/50788772

I received a surprising and disturbing request from NIH on Friday. They wrote to cancel a subaward to Hong Kong on one of my grants. (This was disturbing but not surprising.) They also ordered us not to interact with our collaborators in Hong Kong on any work under the award:

Some of my closest collaborators and many of the best infectious disease researchers in the world are in Hong Kong. We are doing important work understanding immune responses to influenza vaccination, including work that cannot be done in the United States. I have other NIH grants with them.

Sarah Cobey reposted

Sarah Cobey reposted

Per source, NIH has been instructed to hold off from issuing ALL awards to Harvard, Cornell, Columbia, Brown, and Northwestern (including med schools) Agency staff have also been instructed to not speak about this funding freeze to grantees and applicants