Markku Hakala

Recordings from this autumn’s cryo-ET course are published! Thanks a lot @diamondlightsource.bsky.social for making them available!

New paper out: Plasma membrane order maps functional diversity in immune cells We showed how biophysical state of the membranes correlates with the activity of immune cells such as migration and killing. www.nature.com/articles/s41...

I have an open position for a PhD student. In my newly established lab @helsinki.fi we investigate regenerative processes in the mammalian liver. The call is open until October 6th. Apply here: tinyurl.com/mh9k2nav For more information: www.pentinmikko-lab.com Please share!

Plasma membrane order maps functional diversity in immune cells @natchembio.nature.com @sciezgin.bsky.social www.nature.com/articles/s41...

3/3 Huge thanks to my co-organizers Markku Hakala @mhakala.bsky.social James Conway @jrwconway.bsky.social and Shiqi Wang, and to our sponsors @helsinki.fi, @picoquant.bsky.social, @zeiss-microscopy.bsky.social, @spirochrome.com and @ibidicells.bsky.social for making it possible! #FLIM #FCS

Today, the last day of the #FLIM-FCS course at @helsinki.fi with great lectures from @mhakala.bsky.social and Maria Trulsson from @zeiss-microscopy.bsky.social. I got to experiment with an old projector lying around!!

A cell videoed through a DIC microscope. The nucleus spins around. Why would it do that? #CellBiology

Seeking a post-doc for the LaJoie lab at the Human Technopole, Milan, Italy! We are looking for candidates from the fields of biochemistry, cell biology, and proteomics, who are interested in studying protein interactions of the nucleus 🤓 lnkd.in/dTG2CgXF

Hi #membrane folks! This is today, last talks to close this academic year's trafficking seminar season :) 👇

🔬🚀 It's out! Run 100s of imaging experiments before touching a microscope. #VLab4Mic reproduces them in silico from PDB/AlphaFold to help you image right first time. From rockstars Damián Martínez & Bruno Saraiva, inaugural preprint of @mariodelr.bsky.social new lab www.biorxiv.org/content/10.6...

📰The spring TBI Newsletter is out⤵️ mailchi.mp/e17363ccad8d... ▶️Finnish Advanced Microscopy Node received outstanding Euro-Bioimaging SAB evaluation ▶️Imaging in new regional strategy and Health Campus Turku theme ▶️Visits, workshops & Academy Day highlights ▶️BNMI symposium 2026, Levi🇫🇮 ▶️Grants & Events

🚨 Job Alert! 🚨 We have an opening at our Microscopy Core Facility in Turku 🇫🇮. If you love imaging 🔬 and helping scientists succeed, we want you! 👇 abo.rekrytointi.com/paikat/index... #Microscopy #ScienceJobs #CoreFacility #Imaging @turkubioscience.bsky.social

Early bird deadline in 10 days!! This is going to be amazing!

I will be recruiting two postdocs early next year. - One image analyst - one biologist interested in working on lymphatics! Reach out if you are interested 👍

💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n

New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...

Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!

Watch out folks, I don’t wanna alarm anyone, but good news is possible!!

📢Electron Microscopy Unit, Helsinki BioImaging, and ZEISS are organizing a symposium "Frontiers in Imaging: celebrating the EMBI-ZEISS partnership on volumeEM" 🗓️December 2-3, 2025 📍Institute of Biotechnology, University of Helsinki 🔗Program and registration link⤵️ www.helsinki.fi/en/infrastru...

Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...

If you are planning to do Flipper-TR experiments or FLIM imaging in general, I strongly recommend reading this beautiful method paper first! Lots of information about optimal data acquisition for reliable data analysis! Nice work from Tithi, @rouxlab.bsky.social and @juanmagararc.bsky.social !

🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉 🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging www.biozentrum.unibas.ch/open-positio... #biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

Join us for the first @embo.org meeting on Intracellular mechanics and organelle mechanobiology! Registrations are open, submit your abstract by November 14: we have plenty of slots for short talks! #EMBOMechanobio

Halfway to I2K is BACK, friends of all kinds! Last year, 650 people attended 30+ TOTALLY FREE image analysis workshops of all kinds, across many timezones. If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.

Story on our Asgard microtubule paper by Nikki Greenwood: www.quantamagazine.org/tiny-tubes-r... Thanks to all interviewees🎤

For all of you #Actin folks ... It's out ! Happy to help at anypoint

A new #UExM probe for #Actin! Fun times thinking/developing/testing with @centriolelab.bsky.social & @lreymond.bsky.social ! Congrats to all ! If interested in #UExM, or #HAK-Actin, feel free to reach out ! Soon available at @spirochrome.com #Expansion #Microscopy #ProtistsOnSky

Postdoc program at the MDC in Berlin, @mdc-berlin.bsky.social : take a look 👇👇 For this call, collaborative projects between two groups will be funded. Take a look at the call and the groups and drop me an email if interested. Share with colleagues too! www.mdc-berlin.de/postdocs#t-g...

Suomen Akatemia tuomitsee jyrkästi tutkijaan kohdistuvan häirinnän ja vihapuheen. ”In Finland, academic freedom is a core value. Researchers must be able to explore, question and share knowledge openly.” ”Let’s protect the freedom to do science, and the people who make it possible.”

🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs

The EMBO workshop on ESCRT proteins is up and running at Caux Palace. The view from the hotel room to Lac Leman is rather amazing!

I'm grateful for the Research Council of Finland for granting me the Academy Research fellowship! After getting over the shock I will soon move back to Finland to start as a group leader at the Institute of Biotechnology @helsinki.fi. Looking for a PhD student soon! www.aka.fi/en/about-us/...

🧪Hey Sciencers, We're looking to make a library of 50-100 plasmids that differ in ~60bp stretch. The differences will be designed (not random). The library will then be screened for a phenotype. What is the best way to do this? Cost is an issue.

It's fellowship season in the EU. If you want to talk and join our group at the amazing MDC in Berlin on a fellowship, please write me an email. We do cryo-EM/ET, membrane proteins, data science/AI, our work: scholar.google.com/citations?so... Fellowships: Marie Curie, EMBO, HFSP, Humboldt...

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

We have a new review out! In this Microscopy & Microanalysis piece, Louisa Mezache and I survey some of the latest commercially available microscope technologies: Nikon NSPARC, Re-scan Gaia, CSR Biotech MI-SIM, refinements to STED, SMLM from Bruker and Abbelight… Check it out with free access:

Fresh from the press! @lankylaste.bsky.social, @guijacquemet.bsky.social and I put together a practical guide on how to develop software for life science applications.

ESCRT-III is an ancient complex, present in Archaea, with only two proteins and all membrane remodelling functions. Great work by @javierespadas.bsky.social, @diorgeps.bsky.social, @sami-c.bsky.social, thanks to the @buzzbaum.bsky.social lab! Drawing by Julie Polge. www.science.org/doi/10.1126/...

Exciting news! #MembraneTrafficking online seminars with @felixmendu.bsky.social @franbottanelli.bsky.social and me are back! Check the spectacular Jan-April 2025 lineup. Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...

Continuing the peer review discussion: @katherine-brown.bsky.social on principles for effective peer review: 1) Be respectful to authors 2) Request reasonable revisions 3) Focus on whether data support the conclusions 4) Be transparent about expertise limits thenode.biologists.com/peer-review-...

Are you a San Diego local or coming to #CellBio2024? Come join our very special #SciArt Show & Reception on Dec 17, bringing together amazing researchers and artists who have been inspired by the wonders of biology. Please spread the word and RSVP here: beatascienceart.com/artshow2024/

Did you know that FocalPlane now has a #cellbio events calendar? This runs alongside our #microscopy calendar, which is powered by MicroscopyDB. You’re welcome to upload your cell bio event on FocalPlane or use the calendar to help plan your year! focalplane.biologists.com/cell-biology...

Registration is open for the 2025 iteration of the wonderful @EMBOevents workshop on cell polarity and membrane dynamics #EMBOcellPolarity25 I am organizing with Ed Munro! Wonderful lineup wonderful please please sign up and share! meetings.embo.org/event/25-cel...

#MYCOscopy Tip: We rely on SUM projection images for our screening of fluorescent protein/dye content in fungal cells. It's common to use MAX projection for illustration, but for quantitative mesaurments we use SUM. Please contribute to this discussion if there are more insights!