Andrew S. MacDonald

We recently introduced DISCO-seq 🤩: scRNA-seq after tissue clearing 🧬 www.biorxiv.org/content/10.6... Image whole organs or bodies in 3D at cellular resolution. Select regions for unbiased scRNA-seq. From glioblastoma to whole-body SARS-CoV-2 S1 mapping 👇🏻 #DISCOseq

Groundbreaking study from Alex Loukas and Paul Brindley reporting the generation and propagation of the first heritable transgenic #schistosome line! 🧪 🪱 #IDSky www.nature.com/articles/s41...

Delighted to share our paper out today in @natimmunol.nature.com on the overlooked roles of monocytes in the uterus. It has been quite a journey! @lydiabeckeriii.bsky.social www.nature.com/articles/s41...

Congratulations Dr Shorthouse! Very proud of Olivia defending her #PhD thesis today - no corrections! And huge thanks to examiners @immunobladder.bsky.social and @kathelse.bsky.social too. @lizziemannlab.bsky.social @lydiabeckeriii.bsky.social

🧬 Tissue repair is essential—but what happens when it doesn’t switch off? An interesting perspective on how persistent inflammation and repair programmes contribute to fibrosis, and where we might intervene. #Immunology #Fibrosis

Delighted to be a small part of this beautiful new study from @mariakoufaki.bsky.social and @santiagozelenay.bsky.social, identifying a #DendriticCell phenotype and activation state that is critical for anti- #tumour #immunity 🧪 #ImmunSky - congratulations Maria and Santiago!

Congratulations Dr Harrop! Very proud of Ben defending his #PhD thesis today - the future is bright as he starts his postdoc in London! Good luck Ben 😊. And huge thanks to examiners @joyedwardshicks.bsky.social and Jo Konkel too. @lydiabeckeriii.bsky.social

A real pleasure to play a small part in this new study from the Hoffmann lab which uses a genetically humanized mouse that better models human #metabolism to accelerate drug discovery for #schistosomiasis. Very cool! 🪱 🧪 #helminth www.pnas.org/doi/10.1073/...

Thanks to @minsterbantam.bsky.social for visiting and giving a great seminar this week about #immunity and #hematopoesis during #helminth infection #schistosomiasis 🪱 🧪

#TissueTregs have now been found in essentially all tissues, and have broadly conserved properties of enhancing repair and rejuvenation as well as controlling local inflammation. While the impact on tissues differ, molecular mediators are largely shared across tissues.

-> 𝗥𝗲𝗴𝗶𝘀𝘁𝗿𝗮𝘁𝗶𝗼𝗻 and 𝗔𝗯𝘀𝘁𝗿𝗮𝗰𝘁 𝘀𝘂𝗯𝗺𝗶𝘀𝘀𝗶𝗼𝗻 for BSP 2026 in Glasgow are open! The deadline for abstracts for oral presentations is 17 February while the deadline for poster abstracts is 28 February. lnkd.in/eJqXD3DY

On World NTD Day, we are highlighting innovative approaches to fighting NTDs. A recent paper from Swiss TPH shows the potential repurposing of tuberculosis drug candidates to fight Buruli ulcer, a chronic skin disease caused by M. ulcerans. 👉Read more: bit.ly/47WdrXA

Two decades of progress against neglected tropical diseases are now at risk – from funding cuts, climate change, and conflict. This World NTD Day, we must protect progress, unlock financing, and accelerate action. #WorldNTDDay #BeatNTD

🤩 Thrilled our research is a JACI Editor's Choice! 🎉 We identified distinct protein fingerprints (GDNF/CLC) for noninvasive diagnosis of chronic rhinosinusitis with nasal polyps (DOI: 10.1016/j.jaci.2025.08.025)🔬 #CRS #PrecisionMedicine #Proteomics #Immunology 🔗 ino.to/wu9XyBl

hard times in UK for research sector as MRC have announced a funding pause in light of the science secretary announcing an overhaul of how the agency would divide its budget which will dramatically change research....🧪🧵

Lovely to catch up with some of the Manchester crew this afternoon, including new addition Maya 👶, for a Christmas get together 😊🎄🎅🏻 @lydiabeckeriii.bsky.social

Its my great pleasure to say the latest paper from our group is now out: www.mucosalimmunology.org/article/S193... Check it out! We found that immune cell activation in the sputum identifies severe asthma patients. Massive thanks to the patients for agreeing to give sputum and blood samples.

Birds but they get spookier each time. 🎃👻 Enter if you dare...🚪

Here in the uk, the government has found that £1 of spending on R&D results in £8 of benefit: www.gov.uk/government/p...

Insights from Andrea Cooper: Mtb drives expression of type I IFN–mediated #neutrophil accumulation, which limits interaction btwn CD4 T cells & macrophages. Failure to limit type I IFN very early in the process allows rapid progression of disease rupress.org/jem/article/... #Tuberculosis

Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.

Delighted to share this story from my PhD! 🎉 🪱

In schistosome 🪱-endemic areas, people are repeatedly reinfected — but we still don’t fully understand how T cell responses develop in these cycles. In my first ever last-author paper (😱) we investigate this, comparing endemic and repeat controlled human schistosome infection: rdcu.be/exH58

🚨 Want to find interesting cells in single-cell RNAseq data independently of clusters? Try our method to identify transcriptional shifts using OAR scores! Pre-print: doi.org/10.1101/2025... R tool and tutorials: sanin-lab.github.io/OARscRNA/ @biorxiv-bioinfo.bsky.social 1/n

Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...

Fantastic thread on budgeting from @labliston.bsky.social . Great advice for new (and not so new!) PIs. I would add awareness of how psychology impacts spending based on moving from low budget to high budget setting and vice versa....

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

A massive thanks to all the #EMDS2025 speakers, delegates, sponsors & @edinburgh-uni.bsky.social staff for making @emds2025.bsky.social such a success. We had a great time, we hope you did too and your travel home was smooth. Here's to #EMDS2026 in Amsterdam @immunometlab.bsky.social

The end of #EMDS2025 - so much amazing science, and great to meet up in person with so many friends and colleagues (and make some new ones!). Very proud of @vshek.bsky.social and @nwasowska.bsky.social winning poster prizes for the team - well done both!

A fantastic talk from David Russell to end #EMDS2025 - about #macrophage subset responses to #Mycobaterium tuberculosis, and their re-programming to improve drug efficacy in vitro and in vivo

A cracking meal complete with piper & Ceilidh to round off the second day of #EMDS2025 in #Edinburgh

Heading home after a fabulous few days in Edinburgh @emds2025.bsky.social Excellent venue, amazing programme, thanks @bainlab.bsky.social @profandrewmac.bsky.social and Samanta Mariani #EMDS2025 #Macrophage #DCs ♥️

Beautiful data from Franca Ronchese, all the way from @malaghan.bsky.social in New Zealand, about generation and function of subsets of skin #DendriticCells in #allergic responses #EMDS2025

Another great talk from @immunobladder.bsky.social about #macrophage subsets in the #bladder, including in memory response to bacterial infection and key differences in males vs females #EMDS2025

Final day of #EMDS2025 opens with a fantastic talk from Will Wood - beautiful imaging of #macrophage migration following wounding, using the tractability of #Drosophila in ingenious ways to identify key chemoattractants in this process

When the PhD student gives a better talk than his promotors! 👏🏻👏🏻👏🏻 Spectacular talk from @StijnVerwaerde #EMDS2025 🤩🤩. Very cool collaboration with @bart_lambrecht team. Identification of regulatory circuits switching homeostatic regulons to type 2 inflammatory regulons in AMs

Fantastic talk and new data from @lukeanthonyoneill.bsky.social about #mitochondrial control of #inflammation by #itaconate and derivatives in multiple settings #EMDS2025

Really interesting talk from @chrysothemisbrown.bsky.social about ontogeny, transcriptional regulation and function of subsets of #ThetisCells, including their role in #Treg induction and oral #tolerance #EMDS2025

Beautiful and energetic talk from @drpetercook.bsky.social about #DendriticCell uptake of and activation by #fungal spores in #allergic airway #inflammation, and metabolic requirements for this #EMDS2025

Thank you. Very happy to discuss pur work at this amazing meeting! Great times: #EMDS2025

Final talk pre-lunch from @mariolaks.bsky.social defining some of the key #DendriticCell subsets involved in shaping joint #inflammation vs remission, in both human and mouse #EMDS2025

Interesting short talk from Anita Qualls about RORgt+ #APCs in oral tolerance and #Treg induction #EMDS2025

Another lovely talk, this time from David Munro, about the context dependent roles for #HIF1a in #microglia, including in stroke #EMDS2025

First talk so far about #immunometabolism at #EMDS2025 - really interesting murine and human data about mitochondrial (dys)function in #macrophages as a regulator of #inflammation, from @immunometlab.bsky.social

Lovely talk from Samanta Mariani about embryonic #macrophages in hematopoiesis, in health and in malignancy #EMDS2025

Really interesting talk by Barbara Schraml, showing how dietary cues at weaning can activate splenic #cDC1 to induce CTL-like effector CD8+ T cells #EMDS2025

Day 2 of #EMDS2025 starts with a beautiful talk about lung tissue resident #alveolar #macrophage identity and the influence of #IL-33 on this, by Stijn Verwaerde from BART Lambrecht’s lab.

#EMDS2025 attendees - if anyone is looking for a postdoc position and likes what they see of #Edinburgh, please come and speak to me or @lizihegarty.bsky.social (poster 71) or @erinwatson.bsky.social (poster 35).

A fascinating education in #LangerhansCell biology and function from Clare Bennett, as well as a closing advert for the 18th International #DendriticCell symposium in San Diego next year #EMDS2025 #DC2026

Lots of exciting new data from @esegura-lab.bsky.social revealing an important role for Aryl Hydrocarbon receptor #AhR in promotion of wound healing my #macrophages #EMDS2025