Richard Unwin

Richard Unwin

@rdunwin.bsky.social

Mass Spectrometry and proteomics at Uni of Manchester. Analysis of primary samples for biomarker discovery. Development of targeted assays for clinical use. Co-founder, Complement Therapeutics Also football (SWFC), cricket and politics.

935 followers493 following610 posts

Richard Unwin
@rdunwin.bsky.social

Funding success rates and inparticular fellowships are just beyond a joke. System is broken - it's just luck. Any lingering perception that there's actually a meritocracy is just smoke and mirrors at this point, surely?

Research Professional News@resprofnews.bsky.social

ERC Starting Grant applications surge by 60%. Success rate set to plummet as available budget down on previous year. www.researchprofessionalnews.com/rr-news-euro...

researchprofessionalnews.comERC Starting Grant applications surge by 60% - Research Professional NewsSuccess rate set to plummet as available budget down on previous year

Richard Unwin reposted

Blanca Díaz Castro
@bdiazcastro.bsky.social

💫I have a PhD project with Ryan MacDonald and @pdaphd.bsky.social hoping to find a curious and motivated student. If you are interested, please reach out and follow the instructions to apply. If you are PI with bright students looking for projects, please send them my way! 🚨by November 16th 🚨👇🏼👇🏾👇🏿

Richard Unwin reposted

Teresa Rayon
@trayon.bsky.social

Exciting opportunity to lead @babrahaminst.bsky.social’s proteomics facility! Our lab will collaborate on low-input proteomics, SILAC, maximizing the potential of the new Astral mass spectrometer. 🔁 Please share with anyone who might be interested! babraham.current-vacancies.com/Jobs/Advert/...

babraham.current-vacancies.comHead of Mass Spectrometry Facility - Babraham Institute, CambridgeWe are seeking an ambitious and scientifically accomplished proteomics specialist to lead the Babraham Institutes Mass Spectrometry Facility during an exciting period of growth and investment. This i...
Richard Unwin
@rdunwin.bsky.social

I was lucky to recieve a free copy of this and loved it so much I bought a hard copy when it came out. If you love dogs, buy it. It's brilliant and heartwarming and lovely. If you hate dogs, also buy it. It might convince you that you're right! Lol

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Richard Unwin reposted

Richard Unwin
@rdunwin.bsky.social

NEW PAPER: Had a play comparing run length (and software) for DIA proteomics IN PLASMA (cos its not a cell lysate). Tl;dr. If you're benchmarking workflows for differential abundance, checking how many true and false hits you get is a better readout than %CV. pubs.acs.org/jprobs/artic...

pubs.acs.orgBenchmarking ZenoSWATH-DIA and Rapid-Gradient Workflows for Plasma ProteomicsAbstract. Proteomics is the large-scale study of proteins. Mass spectrometry (MS) is one of the most informative techniques for analyzing proteins. Proteom
Richard Unwin
@rdunwin.bsky.social

NEW PAPER: Had a play comparing run length (and software) for DIA proteomics IN PLASMA (cos its not a cell lysate). Tl;dr. If you're benchmarking workflows for differential abundance, checking how many true and false hits you get is a better readout than %CV. pubs.acs.org/jprobs/artic...

pubs.acs.orgBenchmarking ZenoSWATH-DIA and Rapid-Gradient Workflows for Plasma ProteomicsAbstract. Proteomics is the large-scale study of proteins. Mass spectrometry (MS) is one of the most informative techniques for analyzing proteins. Proteom
Richard Unwin
@rdunwin.bsky.social

Well, City are fucked. #swfc got a 12 point deduction for overvaluing the ground to get round spending rules in 2020. Can only assume that doing the same thing, on a far bigger scale, over 8 seasons, and blocking the investigation, will see City down to AT least League 1?

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Richard Unwin
@rdunwin.bsky.social

The statement is seriously damning. PL might chose to not strip them of titles cos that invites chaos. But given how disrespectfully they seem to have behaved - and the scale - I think they'll throw the book at the club. I wouldn't be shocked if they end up being expelled from the League.

Richard Unwin
@rdunwin.bsky.social

Another outstanding thread... 👏👏

Emma Monk@monkemma.bsky.social

🧵 As front-page headlines go, this has to be one of the most misleading I've seen in a long time It's an out-and-out lie But notice the trick they use to get away with it...👀 *They're* not lying - they're just quoting someone else who is👍🏻 In this case, the leader of the opposition🙄 1/33

Richard Unwin
@rdunwin.bsky.social

Science and vaccines for the win!

Roland Pierik@roleo.eurosky.social

The number of cases of cervical cancer reported in Scotland among women given the HPV vaccine at 12-13 years of age is now zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. www.bbc.com/news/article...

bbc.comNo cervical cancer cases in fully HPV-vaccinated women in ScotlandA study published by Public Health Scotland finds that the HPV vaccine is "highly effective".

Richard Unwin reposted

Reese Richardson
@reeserichardson.bsky.social

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

Richard Unwin reposted

Yasset Perez-Riverol
@ypriverol.bsky.social

So easy to download data from @pride-ebi.bsky.social & #ProteomeXchange using pridepy github.com/PRIDE-Archiv.... Here is a short introduction for students youtube.com/watch?v=TiuG... generated with #GeminiNotebook #NotebookLM #OpenData

github.comGitHub - PRIDE-Archive/pridepy: Python client for PRIDE Archive Rest API.Python client for PRIDE Archive Rest API. . Contribute to PRIDE-Archive/pridepy development by creating an account on GitHub.

Richard Unwin reposted

Phil Brickell MP
@philbrickellmp.bsky.social

Fake passports. A money laundering conviction. A mystery casino fortune in Montenegro... There's yet more revelations about who Farage chooses to surround himself with. Let’s start with George Cottrell. A man Farage describes as "like a son," and his former chief of staff 👇

Richard Unwin
@rdunwin.bsky.social

What the actual hell is this???? Do AmericanS really have to put up with this shit in the middle of actual sports event. I WANNA WATCH THE FOOTBALL!!!!! 🙄🙄🤦‍♂️🤦‍♂️

Richard Unwin
@rdunwin.bsky.social

👏 👏 👏 🤦‍♂️

Times Higher Education (THE)@timeshighered.bsky.social

A drop in the number of international students coming to the UK cost the country nearly £3 billion, according to new estimates https://www.timeshighereducation.com/news/fall-international-student-numbers-cost-uk-ps29-billion

Richard Unwin
@rdunwin.bsky.social

Ouch. Strong Steve Morrow vibes after the 1993 league cup final... #swfc

Adaptive Relief UK@adaptiverelief.bsky.social

Unbelievable. In a game he played zero minutes in, Jordan Henderson got himself a yellow card and then needed to be stretchered off after injuring himself falling over the advertising board while singing #Wonderwall #MexEng *Just after the 55 second mark

Richard Unwin
@rdunwin.bsky.social

I've just contacted a company and their rep has replied with an email which looks very much like an AI rehash: 'I understand that you want *lists my request*', 'I'd like to find out more about your *exact wording of application*' etc. Should I be annoyed? Or keep going until I talk to a human?

Richard Unwin
@rdunwin.bsky.social

I have some sympathy for Kier Starmer. Elected to be boring after the chaos of Johnson/Truss wrecked the Tories, his boringness ended up being his downfall. Yes he made mistakes, but I feel his blandness did for him as he couldn't sieze the narrative. He leaves the UK better than when he took over.

Richard Unwin reposted

Jon Lim, FRCP PhD
@drjonlim.bsky.social

Featured on BBC News: #TeamManchester is growing. 🚀 Cancer Research UK Manchester Institute will be receiving an extra £6m a year in investment, creating 8️⃣ senior research roles: 4 group leaders, 2 senior group leaders & 2 clinician scientists. @cruk-mi.bsky.social www.bbc.co.uk/news/article...

bbc.co.ukManchester cancer research lab's £6m extra annual cash boostCancer Research UK Manchester Institute says the extra cash will make a "huge difference" to its work.
Richard Unwin
@rdunwin.bsky.social

Love this. Can just imagine the conversation. Storch: How can we increase our hospitality takings? Hirsty: Let's see if they can keep up with me! 🤣🤣🤣🍺 #swfc

Shane@shane11.bsky.social

Alongside the new Quixall Club is the launch of Hirsty’s social with David Hirst. He will be at (presumably) all home games and again this is fan engagement that might be regular everywhere else but a pipe dream for #SWFC up until 2 months ago.

Richard Unwin
@rdunwin.bsky.social

#FromYorkshire

Rob Chapman@scribblerrob.bsky.social

There's probably never been a better time to remind you that when David Hockney first took his Mum to California she remarked 'all this lovely weather and nobody puts their washing out'.

Richard Unwin
@rdunwin.bsky.social

I stand by a comment I made last week. If Thermo want to be seen as taking this seriously, they should hold themselves to the same standards as their customers are. Anyone using this kind if 'optimisation' in a paper would be looking at a retraction for fraud.

Reese Richardson@reeserichardson.bsky.social

Thermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times. www.thermofisher.com/us/en/home/l...

thermofisher.comthermofisher.com
Richard Unwin
@rdunwin.bsky.social

So do a simple and right thing. Apologise. REMOVE those images where you don't have an unmanipulated original, then rerun your blots and generate a new unmanipulated image. It's not hard... 🤦‍♂️🤦‍♂️🤦‍♂️ Some of the manupulations that have been found are shocking. Doubling down does noone any favours.

Richard Unwin reposted

Reese Richardson
@reeserichardson.bsky.social

Thermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times. www.thermofisher.com/us/en/home/l...

thermofisher.comthermofisher.com
Reese Richardson@reeserichardson.bsky.social

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)