Ryan Senne (he/him)

A-mazing. Gosh, this is wonderful.

This seems a big step forward enabling cortex-wide recordings in naturalistic setups! www.nature.com/articles/s41...

Fuck you if your bag of chips doesn't have a story on the back about why your founder decided to pursue a new approach to chips

👀 arxiv.org/abs/2610.10072

Re-post 🔁 is appreciated! #neurojobs: we’re looking for new team members to join us @cmc-unit.bsky.social!
If you’d like to study decision-making in naturalistic & embodied contexts (integrating RL, RNNs & cross-species data analysis) in a cool & collaborative research environment 😎, check 👇

Glia gang, this is for you! In this video by our #ElectronMicroscopy team, shows a pyramidal neuron (PyC) surrounded by 8 glia brain cells – 5 microglia (MG) and 3 oligodendrocyte progenitor cells (OPC). 🧠📈 http://microns-explorer.org

My initial take on this is that yes some of our previous questions are either solved or feel less relevant. But, scaling isn't producing human like intelligence. There are still fascinating questions. How do we learn and compute with so little sample data and energy? for example.

If you are an undergraduate student interested in computational and systems neuroscience research, this is your chance to attend #COSYNE27 !!! Apply here for our undergrad travel grant tinyurl.com/cos27ugtravel deadline is Oct 30 (and if you are not an undergraduate, please help to spread the word!)

Check out my latest work from the Ramirez lab with co-author @rsuthard.bsky.social! It’s got astrocytes—what more do you need!?

Nature research paper: Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours go.nature.com/3UiC3bT

📣 NEW! I’ve just released the BIGGEST and perhaps most creative project I’ve ever worked on! “Searching for Birds” searchingforbirds.visualcinnamon.com 🐤 A project, an article, an exploration that dives into the data that connects humans with birds, by looking at how we search for birds.

Harrison gives the state-space modeling tutorial at CNN

I co-sign this great summary from @dereklowe.bsky.social . The goal is to destroy academic science, and these are the reasons. And all the “gold standard” and “needs reform” and “not high risk” stuff is transparent bullshit to hide the ball on what they are doing.

Why I’m a fan of the Oxford comma.

Hippocampal engrams configure prefrontal context representations to guide flexible decisions Impressive combo of methods to manipulate and record this process: www.biorxiv.org/content/10.6...

Polls show that only 8% of Americans have a positive view of Adolf Hitler. But in this Palo Alto ketamine bar, that number feels much higher

Today I learned that some of my nested quantile visualizations implemented for R and Python in github.com/betanalpha/m... have been implemented for Julia in the FlexiChains library, pysm.dev/FlexiChains..... Neat!

I’m so outrageously mad having realized a bunch of inane reviewer comments are probably AI. I’m also too busy and would rather be compen$ated for my reviews, but 1) who are we as academics if we don’t value reading and thinking about the literature and 2) dont waste my/student’s time with slop!!

@aloctavodia.bsky.social has been porting Bayesian Workflow book avehtari.github.io/Bayesian-Wor... case studies to Python using CmdStanPy, numpyro, ArviZ, Bambi, and kulprit arviz-devs.github.io/bayesian-wor... He is working on porting the rest of the case studies, too

More evidence, from a large-scale study in China, that using AI hurts learning if it undermines mental effort. When homework time drops due to AI use, so do test scores. Across studies, there is a clear theme: AI tutoring in support of classes is good, using AI to "help" with homework is bad.

How can AI change theoretical neuroscience? Technologies separate us from the mechanics of computation. Are we liberated to focus on the big picture or abandoning the substrate of thought? Born from an ongoing experiment in my lab about balancing these technologies for research and training

Interesting Transmitter article by Brian DePasquale on what will be the effect of the increasingly widespread use of LLMs to code up research ideas in neuroscience. Includes a somewhat sceptical commentary from me. 😉

Check out the new work from the DePaq lab!

Frequentists mogged by priormaxxing

In Jan 2029 a trifecta should pass a large bill package that overturns somewhere between 20 and 50 Roberts Court decisions of the last three decades. We can roll back what they did to legalize political bribery, enable fraud, empower white collar criminals, destroy the govt, etc.

Russell Vought’s OMB published a rule today attacking peer review, which came along with a Murdoch NY Post article favorable to the rule- and attacking peer review. Which all makes the timing of yesterday’s Murdoch WSJ article attacking peer review seem much more suspicious!

And finally it was published! Massive thanks to my coauthors, the editor and reviewers, and the institutions that supported our research. journals.plos.org/plosone/arti...

Congratulations to #FlatironCCN director @eerosim.bsky.social on his election to the National Academy of Sciences! https://bit.ly/42AEUhl #science #neuroscience

Super excited to (finally!) show our work on identifying cell types! Now in press www.nature.com/articles/s41.... We show how to identify cell types from ephys recordings *without* optotagging. This opens the study of not just individual cell types, but the interacting neural circuit during behavior

There seems to be a broad perception across psychology and neuroscience that work shouldn't be "too technical" in order to reach the broadest possible audience. While I think we should strive for accessibility, I feel that this attitude can also be self-defeating: why are we dumbing down?

The Orange Cat Brain Atlas is here. 🧠🐈 Today, we published the first comprehensive cellular map of the orange cat brain. The new atlas reveals a single, specialized neuron responsible for behaviors like staring at walls, knocking objects off tables, and the 3am "zoomies."

Cosyne invited me to give a long tutorial (4 hours!) on methods to quantify differences high-d neural recordings across animals, brain regions, deep neural nets, etc. The recording is up on youtube. I hope it inspires more research on this fundamental topic! www.youtube.com/watch?v=n44x...

ArviZ 1.0 is out! We have refactored it to be more modular, flexible & lightweight. For an overview of the changes, check the migration guide. python.arviz.org/en/stable/us...

Checkout the notebook of this epic neuroscience dataset now on @dandiarchive.org and analyzed with pynapple!

So happy to announce my first published paper: Neuropixels reveal laminar microcircuit organization in monkey V1 in vivo www.pnas.org/doi/epdf/10....

I am a pro-AI guy who often gets pigeonholed as an anti-AI guy. I am pro developing and using AI for things AI is good at. I am anti developing and using AI for things that will bring on another AI winter, a mild economic collapse, and make us all look like schmucks in ~5 years.

As a proud Minnesotan, I second this

Gary Larson: In my cartoon I invented Cow Tools as a cautionary tale Cows: At long last, we have created the Cow Tools from classic newspaper comic Cow Tools

Walz: "What's happening in MN defies belief. News reports simply don't do justice to the level of chaos & disruption & trauma the federal govt is raining down... This long ago stopped being a matter of immigration enforcement. Instead, it's a campaign of organized brutality against the people of MN"