Joseph Schacherer

Excited to share our preprint! “Genome-scale base editing reveals the functional effects of variants in yeast” Using high-throughput base editing, we measured the growth effects of 308,461 variants, identifying 18,009 with significant effects. #Genomics #CRISPR 1/8 www.biorxiv.org/content/10.6...

#bioGUNE_Seminars | 🗣️ “From Supramolecular Chemistry Towards Adaptive Chemistry” by Jean-Marie Lehn from Université de Strasbourg CNRS 📅 Thu, Oct 1 🕛 10:30 📍 #CICbioGUNE, Bldg 800 – Atrio 800 📅 More seminars: https://www.cicbiogune.es/activities

New paper out in Yeast: Fellipe de Mello & team established a collection of ecologically diverse Brazilian yeasts and screened their performance in industrially relevant conditions, discovering some species that could be used for industrial applications 🇧🇷 onlinelibrary.wiley.com/doi/10.1002/...

Exciting news: @uwgenome.bsky.social will be hiring for two tenure-track faculty positions this year, one open rank and one assistant professor. Both are “Genome Sciences” interpreted broadly so we welcome applicants working in a variety of fields and methods. Ad will be out shortly.

Hey! You can have a look at our new preprint on #CellCycle regulation and #Pluripotency! A little thread 100% human 0% AI slop is coming (bear with me the mistakes). Let's thank first @maulik_nariya, the fantastic postdoc that led this project: www.biorxiv.org/content/10.6...

🍷🧬 Save the date! #ICYGMB2027 the 33rd Int'l Conference on Yeast Genetics & Molecular Biology comes to Porto, Portugal, July 19-22, 2027! A stellar international lineup of speakers + 16 workshops across yeast biology. Full details 👉 www.i3s.up.pt/ICYGMB2027 #YeastGenetics

To test these ideas, we used a collection of wild S. cerevisiae isolates, initially assembled by the @schacherer.bsky.social #haploteam lab (www.nature.com/articles/s41...) and subsequently barcoded by Abhishek and Marion for their recent paper: www.nature.com/articles/s41...

I’m excited to share our preprint with @oliviamghosh.bsky.social, where we explore what it takes to ‘win’ in long-term evolutionary competition: www.biorxiv.org/content/10.1...

It’s almost time! Join 2026 GSA Medal recipient @schacherer.bsky.social next week on September 15 to learn how pangenomics, long-read sequencing, and deep phenotyping are revealing new insights into the genetic basis of complex traits and missing heritability. 🔗https://buff.ly/SsNmgsN

Latest in #GENETICS: Read the inspiring journey of the Genetics Society of America Medal awardee @schacherer.bsky.social and learn about his contributions to #yeast research, including leading the 1000 Yeast Genomes Project. 🔗 buff.ly/V5yPKkl

How does genetic variation shape complex traits? Join 2026 GSA Medal recipient @schacherer.bsky.social of @unistra.fr on September 15 at 1:00 p.m. EDT as he explores how pangenomics is revealing new insights into the genetic basis of complex traits. 🔗 buff.ly/0JCxhmI

Really proud of this piece, led by @timothyfuqua.bsky.social , finally published in GBE! Tim's post perfectly explains what it hopes to achieve.

Our deep mutational scan of G6PD is out in final form! @reneegeck.bsky.social did an incredible job on the project, & @dougfowler.bsky.social has been fantastic to collaborate with, as usual. Really gratifying to contribute functional evidence on VUS classification for G6PD deficiency. rdcu.be/fyTlf

Excited to share this personal story published by @GeneticsGSA. A reflection on my journey in genetics, the many people who shaped it, the @haploteam and my enduring fascination with diversity. Thanks to everyone who has been part of the adventure! academic.oup.com/genetics/adv...

Excited to share our latest #haploteam paper! We developed a barcoded collection of 520 natural yeast isolates to screen 600+ compounds at population scale, uncovering how natural genetic variation shapes chemical responses. Congrats to Abhishek and Marion, who led this work! doi.org/10.1038/s414...

Our laboratory is looking for a PhD student in Functional Genomics (fully funded position). Expected starting date: Oct 2026 More info here: www.igbmc.fr/en/igbmc/lif... Please share 📨

Nice write-up of our latest paper: news.uark.edu/articles/82610 And could not have been done without the support of NSF and NIH.

Oh. Looky here #SciSky. New work from former PhD student Sabrina Chau along with our collaborators in the Laxman lab. A couple of main points: 1. Attenuation of a yeast dsRNA virus is accomplished through amino acid restriction.

Essays, written on the same occasion but a decade apart, by two lovers of genetics ❤️ @genetics-gsa.bsky.social @schacherer.bsky.social

Our new paper was, by definition, an adventure: stepping outside of our comfort zone, embracing the unknown, and engaging in activities where the outcome is uncertain. Includes discovery of a new species and working with a Native American tribe to name it… 🧵👇 onlinelibrary.wiley.com/doi/10.1002/...

Not being able to access the @ukbiobank.ac.uk is becoming a significant issue for a PhD student in our group and I can only imagine this is mirrored in many other places. It would be fantastic to at least have a timeline we could work with.

Our paper on the evolution of cellular miniaturization is now out in PNAS! www.pnas.org/doi/10.1073/... A short recap 🧵

Congratulations to @schacherer.bsky.social @unistra.fr recipient of the #Yeast26 GSA Medal! Great to hear the journey to identifying structural variants in #1011YeastGenomes, tackling heritability, genetic diversity, and genotype-phenotype @genetics-gsa.bsky.social

Super excited to share our lab's work led by PhD student Margot Ruffieux on domestication of Saccharomyces cerevisiae, with a focus on sourdough and baking associated yeast! 🍞

14th Ekiden for the HaploTeam already - I can't believe it. But first since we moved to @igbmc.bsky.social! The competition between the Haplo and Diplo subteams was tough but as always, great fun and team spirit!

⏰ Only 2 DAYS left for early registration! Join us at #Yeast26 (June 13-17, Pacific Grove, CA) for cutting-edge research in #genetics, #genomics, #disease, #regulation, #systemsBiology, #cellBiology, #lifeCycle, #syntheticBiology, & more. Register by April 16 to save! 🧬 genetics-gsa.org/yeast-2026/

New from my lab: Ancestral sequence reconstruction analysis indicates the furin-cleavage-site insertion in the SARS-CoV-2 spike gene likely interrupted a codon academic.oup.com/ve/article/1...

🌊 Get ready for YGM2026- the ultimate #Yeast genetics experience! World-class science meets Pacific Grove paradise June 13-17 🏨 Stay on-site: deadline April 8 ⏰ Conference registration ends April 22 This is THE meeting you don't want to miss! We'll see you there! #Yeast26 #Asilomar #YeastGenetics

🎤 Meet the PYFF9 speakers! Yeast & Fungi Conference 2026 in Valencia (8–11 Sept) 📢 Registration & abstract submission open 🔗 yeastfungi.efbiotechnology.org/home #Yeast #Fungi #Biotechnology #CallForAbstracts @pyff-9.bsky.social

#Yeast #Genetics Meeting 2026 is in June - Abstract deadline is TODAY! Submit your abstract, attend the meeting this summer in Pacific Grove, CA at #Asilomar Conference Grounds, a 107-acre protected coastal state park located on the Monterey Peninsula. #Yeast26 #YGM2026 genetics-gsa.org/yeast-2026/

We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations. www.evocellnet.com/2026/03/mapp...

📢 Reminder: March 5 is the abstract submission deadline for the Yeast Genetics Meeting. Don’t miss the chance to share your work—submit an abstract and encourage colleagues to attend! genetics-gsa.org/yeast-2026/

Thrilled and honored to be part of the 2026 GSA Award recipient! This honor reflects years of teamwork - huge thanks to everyone who has been part of the #haploteam. Proud to share this with you all! @genetics-gsa.bsky.social genestogenomes.org/the-2026-gsa...

We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD. www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism

Sad to learn that David Botstein has passed away. Few people truly shape how you think and do science, and David was definitely one of them. I had a fun and influential time at Princeton with the Botstein, Kruglyak and co gangs. It shaped the way I do science. www.online-tribute.com/DavidBotstein

www.biorxiv.org/content/10.6... comparison of commercially available #Saccharomyces #mead yeasts. Our new preprint w/ @balintnemeth.bsky.social and colleagues compares 13 mead #yeast strains for their phenotype, genome, and presents data on metabolites in experimental mead fermentations.

Finally…

New Perspective!🔥It's fascinating how scientists from different fields but interested in the same question [e.g. genotype-phenoytpe relationship] can have such different perspectives. Here we put in our 2 cents wrt genetic effects being context-dependent, and pheno variation being mostly polygenic

Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14

With @litinice.bsky.social, we built a haploid resource from 33 wild Taiwanese Saccharomyces cerevisiae strains — including some of the most genetically divergent Asian lineages — to bring natural yeast diversity into a genetically tractable framework. www.biorxiv.org/content/10.6...

Registration is open for the inaugural GRC conference in the Function of Evolving Systems. Aug 9-14, 2026, Waterville Valley. Truly stellar speaker lineup. Student/postdoc fellowships are available! Please come join us! www.grc.org/function-of-... @joybergelson.bsky.social

New lab preprint - Common and rare variant studies for the same trait identify different genes and here Diederik Laman Trip developed a protein network AI enconding to investigate if traits studied by different approaches converge on the same molecular pathways www.biorxiv.org/content/10.6...

Excited to announce our latest publication in reporting evidence for three (3!) new whole genome duplications (WGDs) in yeasts. Scientists have often wondered why WGD is so rare in fungi, it turns out we may just not have been looking hard enough! 🧪 🍄 🧬 www.sciencedirect.com/science/arti...

Expressions of interest: Director at MPI EvolBio (f/m/d) — We invite expressions of interest from distinguished scientists in evolutionary biology with a bold, long-term research vision that complements our Institute. More information: www.evolbio.mpg.de/3856225/Dire...

✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity. www.nature.com/articles/s41...

📣 #EMBOEvoEco returns in 2026 to uncover the mechanistic foundations of ecological and evolutionary change! Keynote lectures will spotlight the ecology and evolution of symbiosis. Submit your abstract for the EMBO Workshop: https://s.embl.org/eae26-01-bl!

Abstract submission for #Yeast26 is now open! 🍞🍺 Browse abstract submission topics online and start preparing your abstract today. Topics include disease models & aging, evolution & population genetics, gene regulation, genomics & systems biology, and more! Learn more: buff.ly/qotaLne

2026 is the 50th anniversary of the Cellular and Molecular Fungal Biology GRC. It will be June 21-26, 2026. Consider attending this is a great meeting if you work in the fungal biology field at genetic / genomic / molecular scale. www.grc.org/cellular-and... 🍄🧬🖥️