Simona Huwiler

Simona Huwiler

@simonahuwiler.bsky.social

Microbiologist, Predatory Bacteria & Novel Antibiotics. Research Group Leader at University of Bern. ERC Starting Grant Assistant Professor.

1.9K followers1.6K following51 posts

Simona Huwiler reposted

Cover image alert 🎨🚨👇🏼 - check out the amazing drawing of Sophia Zimmermann from our group in Nature Microbiology @natmicrobiol.nature.com ! Fun fact: Sophia initially drew it as a present to Dorentina @humollidorentina.bsky.social when we celebrated her recent paper on TnSeq with phages 🥂😊.

Dorentina Humolli@humollidorentina.bsky.social

We wrote a short “Behind the Paper” post about our HIDEN-SEQ journey together with @aharms485.bsky.social. Check it out: go.nature.com/4yBHsdy Special to share it with the @natmicrobiol.nature.com cover, featuring the amazing art of the great scientist and artist Sophia Zimmermann from our lab!

Simona Huwiler reposted

The final version of our manuscript on TnSeq in bacteriophages (“HIDEN-SEQ”) is out today – if you have an interesting phage phenotype and want to know the underlying genetic basis, this one is for you! 1/4

Simona Huwiler reposted

Predation resistance mechanisms operate at an individual level, adaptations are sometimes pleiotropic and compensatory. Thanks to all my co-authors who made this research possible Ove, Sarah, Saskia, Bernd, @rkmicrobes.bsky.social @simonahuwiler.bsky.social #AMR #Bdello #Evolution tiny.cc/2qpa101

tiny.ccOuter membrane changes enable evolutionary escape from bacterial predationAbstract. Antimicrobial resistance (AMR) is a threat to modern medicine. To combat AMR pathogens, natural predators like bacteriophages and predatory bacte
Subham Mridha@subhammridha.bsky.social

Our paper in @isme-microbes.bsky.social uncovers the genetic causes of predation resistance in bacteria, that predominantly occur through outer membrane changes. Adaptations are metabolically expensive. This has great implications in the clinical setting for use of #BALOs.

Simona Huwiler reposted

Dear all, I have the pleasure to inform you that the online course "Resistance to Antibacterial Agents", produced by the Institut Pasteur, will start on November 3, 2026. How does ABR emerge and spread? ... 🔗 www.fun-mooc.fr/en/courses/r...

fun-mooc.frResistance to antibacterial agentsThe origin, risks, diagnosis, epidemiology of resistance to antibacterial agents in man and livestock worldwide, as well as preventive and countermeasures, in a « one health » perspective.

#AMR superbugs are getting tougher, but predatory bacteria like B. bacteriovorus can hunt them down! We show that model bacterium E.coli 🦠 can escape these ‘living antibiotic’ by evolution, mainly through OmpF porin loss. This comes at a cost. Details at: tiny.cc/2qpa101 #MicroSky, #Evolution

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#AMR superbugs are getting tougher, but predatory bacteria like B. bacteriovorus can hunt them down! We show that model bacterium E.coli 🦠 can escape these ‘living antibiotic’ by evolution, mainly through OmpF porin loss. This comes at a cost. Details at: tiny.cc/2qpa101 #MicroSky, #Evolution

Simona Huwiler reposted

Simona Huwiler reposted

Simona Huwiler reposted

Simona Huwiler reposted

Studies have shown that sleep deprivation can be equal to the effects of drinking alcohol for reaction time & attentiveness. For multiple nights now, many Basel residents won't have slept well in extreme heat - but may still be driving or operating machines. Be safe in this extreme heat everyone!

Simona Huwiler reposted

What’s holding back clinical use of phage therapy in the UK? Our workshop last year brought together international experts, biotech and regulators to find out Meeting Report out now in Nature Microbiology with our take on the challenges and opportunities facing the UK phage therapy sector

Simona Huwiler reposted

A new year brings new opportunities: we are looking to fill a permanent professorship position with a Microbiologist preferably with expertise on archaeal biology, RNA biology or imaging techniques to unravel cell biology in prokaryotes! Please share and/or apply :)! www.nature.com/naturecareer...

nature.comProfessurship (W2) in Microbiology - Regensburg (Stadt), Bayern (DE) job with Universität Regensburg | 12851113UNIVERSITY OF REGENSBURG   The Faculty of Biology and Pre-Clinical Medicine invites applications for a   Professurship (W2) in Microbiology   To be...

Simona Huwiler reposted

Simona Huwiler reposted

TIL about a memorial ceremony in Iceland in 2019 to mark the end of a glacier, changing the place name from Okjökull to Ok (jökull = glacier). Uncompromising wording on the bronze plaque: "This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".

Ever wondered what happens if 💊antibiotics are not effective anymore? In this online article I summarize the efforts in the field using 🦁🦠predatory bacterium Bdellovibrio bacteriovorus as ‘living antibiotic’: tinyurl.com/4dmt9dps #AntimicrobialResistance #AMR

tinyurl.comCombatting AMR: The potential of Bdellovibrio bacteriovorus as a ‘living antibiotic’Simona Huwiler discusses the potential of Bdellovibrio bacteriovorus, a predatory bacterium, to address the growing concern of AMR.

Simona Huwiler reposted

🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8

Simona Huwiler reposted

🚀New preprint from our lab! I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡 Continue reading (🧵)

Simona Huwiler reposted

Join us in Colorado next spring for the Keystone Symposia “Beyond #Antibiotics: Emerging Strategies Combating #BacterialInfection”. Registrations are now open! Details below ⬇️

Joe Zackular@joeyzacks.bsky.social

Registration is now open for @keystonesymposia.bsky.social "Beyond #Antibiotics: Emerging Strategies Combating #BacterialInfection." Deadline for scholarships and abstract selected short talks is Jan 7! Join us this May for an amazing meeting! keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26

Simona Huwiler reposted

This #WAAW Don’t forget to get your awesome AMR abstracts submitted to join us in Hinxton to discuss AMR genomics, innovations in diagnostics, therapeutics, and data analytics, and novel mechanisms of antimicrobial survival! #AMR2026

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Simona Huwiler reposted

Simona Huwiler reposted

Our article on a 🛠️ molecular toolbox 🛠️ in predatory bacterium 🦁🦠 Bdellovibrio bacteriovorus is published in PLOS Genetics (=> tiny.cc/6wuu001). 🎉 This supports the research on this bacterial predator-prey system & future bioengineering efforts. #MicroSky #SyntheticBiology #PredatoryBacteria

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Our article on a 🛠️ molecular toolbox 🛠️ in predatory bacterium 🦁🦠 Bdellovibrio bacteriovorus is published in PLOS Genetics (=> tiny.cc/6wuu001). 🎉 This supports the research on this bacterial predator-prey system & future bioengineering efforts. #MicroSky #SyntheticBiology #PredatoryBacteria

We advance the genetic toolbox 🛠️ regarding manipulation of predatory bacterium 🦁🦠 Bdellovibrio bacteriovorus in two ways: First, by fine-tuning gene expression with a focus on the ribosomal binding site and ...

Simona Huwiler reposted

Switzerland is joining Horizon Europe! We are uniting two research powerhouses. For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more. Today is a good day for science, and for our EU-Switzerland partnership.

One of nature’s tiniest predators 🦁 is Bdellovibrio bacteriovorus which kills, invades & eats up other bacteria 🦠. Studying predator protein abundances we found a bacterial prey-degradation enzyme. Read full blog article in Springer Nature Research Community here: tiny.cc/zmju001 #Microsky

Simona Huwiler reposted

Replying to @odedrechavi.bsky.social

and if you don't know what we're talking about bsky.app/profile/oded...

Oded Rechavi@odedrechavi.bsky.social

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Simona Huwiler reposted

📢 Join the Microbiology Society at Innovations Against AMR 2025! We’ll be leading a Policy Workshop exploring how science, regulation and innovation come together to tackle antimicrobial resistance (AMR). 👉 Register for free here: www.medilinkmidlands.com/event/in-per... #AMR

medilinkmidlands.comIN PERSON Event: Innovations Against AMR 2025 - Medilink MidlandsThe 4th annual Innovations Against AMR summit, co-organised by Medilink Midlands and Cytecom, will convene experts […]

Multiple small, curved, predatory bacteria (Bdellovibrio bacteriovorus) lyse the bacterial prey remnants below. How are they doing this & which predator proteins are involved in this process? See our newly released research article 📑 => rdcu.be/eL6gu 🦠 #microsky #bacteria #PredatoryBacteria

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Multiple small, curved, predatory bacteria (Bdellovibrio bacteriovorus) lyse the bacterial prey remnants below. How are they doing this & which predator proteins are involved in this process? See our newly released research article 📑 => rdcu.be/eL6gu 🦠 #microsky #bacteria #PredatoryBacteria

Our work ✴️ presents the first quantitative predator proteome over the whole predatory process in which B. bacteriovorus (the predatory bacterium) kills, digests and lyses the bigger prey bacterium. ✴️ reveals that one predator protease is highly abundant during and involved in the prey exit process.

Simona Huwiler reposted

AMR kills 1.27M people each year — we urgently need new solutions. On #WorldPhageDay, we celebrate phages: nature’s powerful allies against bacteria. At INCATE, we support innovators bringing phage therapies to life. Working on one? We want to hear from you! #AMR #Phage