Bending Lab UK

PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells •PD-1 & Lag3 exhibit layered control of CD4 T cell activation •Co-blockade enhances NFAT-dependent TCR transcription •NFAT inhibition reverses functional effects of anti-PD-1&Lag3 doi.org/10.1093/immadv/ltaf015 @imtadvances.bsky.social

Congrats to #ListerFellow David Bending and colleagues on @medresfdn.bsky.social funding to advance safer, more personalised cancer care 👏 David will investigate role of T peripheral helper cells in immunotherapy side effects. @bendinglab.bsky.social www.birmingham.ac.uk/news/2026/bi...

MRC curiosity-driven research reopens with new approach www.ukri.org/news/mrc-cur... MRC applicant-led funding opportunities reopen 7 Apr, experimental medicine opportunities opening 30 Apr Complete change in selection of project: no boards, shortlisted applicants -> in-person panel interview.

www.bbc.co.uk/news/article...

Has the MRC made a public statement yet

It's today! Our #BSIMidlands25 kicks off with an overview of the history of clinical immunology in the Midlands by Dr Aarnoud Huissoon

We are very proud to introduce our brand new 2025 #ListerFellows! This year there are eight Prize recipients. lister-institute.org.uk/a-warm-welco...

Honoured to receive this prize alongside an inspiring group of scientists. This will support our work to improve mRNA therapies for precision medicine. #mRNA #immunoSky #Science

Lovely work!

Congrats to the team! Very nice study. I find it especially interesting that blocking NFAT can compensate for the effects of anti-PD1/LAG3.

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥 Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5) Please share!

Our new blog post spotlights the Lister Institute's ties with @unibirmingham.bsky.social, home to Lister Fellows past and present @bendinglab.bsky.social @agagambus.bsky.social @sarahdimeloe.bsky.social sky.social @therad-lab.bsky.social @tunglejic.bsky.social lister-institute.org.uk/shining-a-li...

#Immunology out now @science.org After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen. buff.ly/49bKcTG By Jobin, Seetharama, Rüttger et al.

Check out latest work from @bendinglab.bsky.social - new insights into IFNg regulation of TCR signalling! 🧪 #immunosky

Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans @jem.org rupress.org/jem/article-...

A new paper from #ListerFellow @linterman.bsky.social and colleagues explores the role of tertiary lymphoid structures (TLS) in #bcell immune response. @pnas.org doi.org/10.1073/pnas...

Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in humans with an XX chromosomal background. From @hlpeks.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin et al. rupress.org/jem/article/...

📣 New Review Alert! Do you think glial cells are simply neuronal support cells in the CNS? Did you know glial cells are integral to barrier organs? Check out our latest review exploring the fascinating crosstalk between glia and immune cells in the gut, lung and skin! #GlialCells #ImmuneSystem

Excited for our lab's FIRST paper #ScienceImmunology! 🎉 Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social Huge thanks to reviewers & @claireolingy.bsky.social 🙌 #Tpex #onthescoreboard www.science.org/doi/full/10....

The BSI has grants available for our members who want to help get more people excited about #immunology

⏰ Last few days before the deadline of midday (GMT) Friday 10 January if you are thinking of applying for one of our Medical Research Council fully funded 4 year PhD studentships at our partner institutions @uniofnottingham.bsky.social @unibirmingham.bsky.social or University of Leicester 🧵

great opportunities!

I’m so excited about this project, it’s going to reveal so much about how the glycocalyx works, amazing opportunity!!

BLUESKY MEGA-THREAD Altmetric is thrilled and also LITERALLY RELIEVED to officially announce: We are now tracking research attention as it happens on Bluesky! We have been picking up posts on the site since late Oct. Our team is on Bluesky all day answering questions. Let's get into it!

There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research. A Place of Joy.

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

Before you go - a couple of fun side notes from the sup figures. FIRST, we could have missed this phenotype without the Timer system, EV1 shows comparison with the Nr4a1-GFP and Nr4a1-Timer. GFP gives the impression all is fine bc it sticks around-don't get the info of seeing it turned off. 10/12

Great fun to be involved in this project! 🧵below well worth a read 🧪

T cell receptor–centric perspective improves single-cell analysis www.science.org/doi/10.1126/...

The University of Birmingham is now on here! @unibirmingham.bsky.social

Professorship of Infection / Immunity up for grabs in @cambridgeuni.bsky.social www.jobs.cam.ac.uk/job/49381/

"Nivolumab proved highly effective in advanced dMMR/MSI tumors. Expression of key innate immune receptors/ligands was the main predictor of a good treatment outcome, contrasting findings in melanoma and strengthening the rationale for tumor type–specific biomarkers for guiding #immunotherapy."

What an opportunity!

I’m biased of course but this is a detailed new mechanism for the direct action of IL-2 on antigen-experiencing B cells, driving early/extrafollicular antibody responses! Congrats to @katyely.bsky.social and all co-authors on a job diligently and well done! Glad I could help #immunosky #bcells

Two fully funded PhD opportunities in our lab. Interdisciplinary, DNA replication, cancer research, structural biology… deadlines in early Jan. Open to international students. t.co/WEJJIU4zU4 www.findaphd.com/phds/project...

New PhD opportunity in the lab with @profjudiallen.bsky.social and @douglaspdyer.bsky.social looking at interactions between ILCs and the extracellular matrix. Application deadline Jan 10th 2025 - spread the word Bluesky immunologists! www.findaphd.com/phds/project...

If you’re interested in a project please contact the lead supervisor to find out more, and make sure you complete the application form by 10th January!

There’s a really exciting range of PhD projects on offer through the MRC “AIM” doctoral training partnership between the Universities of Birmingham, Leicester and Nottingham. 4-year funded studentships with great training opportunities too. Check out the options: more.bham.ac.uk/mrc-aim/phd-...

One of this projects is ours 😀. Please send interested students our way!

Applications now open for our MRC AIM DTP 4 year fully funded PhD studentships across the Universities of Birmingham, Nottingham and Leicester. Deadline for applications is Friday 10th Jan 2025. More details and how to apply in the following link🧪 more.bham.ac.uk/mrc-aim/phd-...

Delighted to welcome back Alyssa Silva-Cayetano for her 2024 Berridge Prize lecture on #ageing and the germinal centre response. Her research with the @linterman.bsky.social team brought together mice models, in silico modelling and human samples. Paper below! 👇