Manuel Mendoza

Our story on Srs2/PARI family DNA helicases linking chromatin bridges to the Aurora-B dependent NoCut checkpoint is now out in its peer-reviewed version. Thanks to @reviewcommons.org and @jcb.org for a smooth review process! Original preprint thread here: bsky.app/profile/long...

1/8 What bothers me most about this Nature essay is its portrayal of evolutionary biology as a simplistic, gene-obsessed discipline finally being rescued by an appreciation of complexity. It's a compelling narrative, but a poor scientific argument.

No-one knows how yeast take up DNA in transformations. Really! (Ok, endocytosis is required.) We noticed that "yeast transformation mix" w/ Lithium salts, PEG, carrier DNA ... is exactly the mix that chemists use to make DNA phase separate. Our review paper in Yeast Journal! w/ Alistair Elfick 1/

Our Dept. of Genetics and Developmental Biology at the Institut Curie in the heart of Paris is hiring a new junior PI. It has a nice start up package and excellent I. Curie facilities. Please spread the word: Deadline Dec. 18th! jpi-recruitment-curie-umr3215-u934.curie.fr

using the 49-day measurement for a Truss, a Zacharia would be 0.143 Trusses

Katie Zacharia Is Out After 0.5 Scaramuccis as White House Press Secretary www.nytimes.com/2026/10/16/u...

Nuclear speckles are “hot”, but how do they actually sequester mRNPs? We find that stalled mRNPs are retained in nuclear speckles by a combinatorial RNA-binding protein network. www.biorxiv.org/content/10.6...

Very happy to see our work highlighted by @natcellbio.nature.com. A great team effort and a fascinating example of how a simple physical principle can connect mitosis across eukaryotes! @lgudlin.bsky.social, @krunovuk.bsky.social, @kopslab.bsky.social

How cells adapt their membranes to prolonged stress is poorly understood. Williams, Klose, Ernst, and Carvalho @dunnschool.bsky.social show that chronic hyperosmotic stress triggers #LipidDroplet accumulation and a shift toward phosphatidylcholine in budding #yeast. rupress.org/jcb/article/...

Hierarchical TPR:ZC3HC1 interactions drive stepwise assembly of nuclear basket extensions projecting into vertebrate cell nuclei https://www.biorxiv.org/content/10.64898/2026.10.08.757499v1

Guys! @jbahler.bsky.social and I are recruiting a PhD student in this round - if you know great undergrads or Masters students please tell them about us! And Crick in general, of course ;) Thank you!!

People!!! This workshop will be ACE - please share, please apply!

Biophysics, membranes, evolution, yeast 🙌 @alebenoit.bsky.social does it again! www.cell.com/biophysrepor...

🤦🏻‍♂️

What molecular mechanisms underlie the needle-in-a-haystack search for homology required to fix a DNA break? In this preprint, we reveal multiple controls of homology search in cells: onset, coordination, reach and inactivation. www.biorxiv.org/content/10.6...

“At least for now, until the robots come…”

“People who have stayed in Russia have accepted the rules of a game … there are artists who used to make strong statements, and in 2026 they are drawing flowers in a vase.” www.theguardian.com/world/2026/s...

The 4DN Center for 3D Structure and Physics of the Genome proudly presents: "Stepwise reorganization of chromosome conformation and nuclear organization during stem cell differentiation". www.biorxiv.org/content/10.6...

@timmiller.bsky.social and @anneapplebaum.wsocial.eu on the U.S.-controlled system for selling Venezuelan oil and assets: "Congress doesn’t have oversight...there’s just rogue bank accounts out there with Venezuelan money."

Pierre Chambon was one of the driving architects of modern molecular biology, whose scientific vision transformed the understanding of gene regulation in eukaryotic cells. His passing in May 2026 represents the loss of an extraordinary scientist. www.nature.com/articles/s41...

Are we allowed to know where all the money is from the oil we’ve plundered from Venezuela? Where is it? How much is it? Has any of it been spent? Who has profited from it? Can we get a full accounting or is that too much to ask? I realize Republicans in Congress don’t care.

Reading recommendation for #PeerReviewWeek @ethanewe.bsky.social highlights a study that looks at 115,000+ PLOS papers to explore who chooses open peer review and whether openness relates to article quality. #preprint Adrian Barnett & Matt Spick #preLight⬇️ prelights.biologists.com/highlights/w...

Elizabeth Holmes is gonna crawl out of your computer monitor in seven days unless you show this to someone else

there's a teaser trailer and everything youtube.com/watch?v=GGJSRFWALTI&feature=youtu.be

Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22

Another AI agent swarm cooperation example discovered on a wiki. That these things are not atracting more public discussion is beyond me. collusion.wiki

HAHAHAHAHAHAHAHAHAHAHAHAHAHA! EPIGENETIC HULK LIKE THIS SMASH! NO SMASH NOTES! www.cell.com/cell-genomic...

We would like to add one or two postdocs to our lab in the next couple of years. If you are close to finishing your PhD and interested in the science we do, feel free to reach out to discuss opportunities.

*JobAlert* One more week to apply for a post-doc position in my lab at Dundee to study co-translational protein quality control of secretory and membrane proteins. This is a collaborative project with @kulathu.bsky.social and @zeqiraj.bsky.social www.jobs.ac.uk/job/DSM201/p...

First preprint from the lab 🚨 We asked when and how global chromatin organization emerges during early development 🐟

Who needs chromatin anyway...? NOT THIS GUY! www.biorxiv.org/content/10.6... 1/n

This is an absolutely delightful thread

Excited to share our newest work! We asked whether RNA molecules need to be in a specific place in the cell to do their job. We found that a single RNA must reach the midbody, the structure that pinches two dividing cells apart, for cell division to finish efficiently. 🧵⬇️

🌓🌎🌞 <-- lunar eclipse 
🌎🌓🌞 <-- solar eclipse 
🌎🌞🌗 <-- apocalypse

I've finally found it. The most painful science montage in movie history. Mega Shark Versus Giant Octopus (2009) Yes, Gen X, that is singer Debbie Gibson as oceanographer 'Emma MacNeil'. But the important thing is: she's keeping an accurate lab notebook.

#TunnelingNanotubes and #cytonemes in cancer and development Kenneth M. Yamada (@niaidnews.bsky.social), David A. Cruz Walma, and Wakako Endo: rupress.org/jcb/article/... #CellSignaling #Development #cancer

Published!!! Homeostatic fun!!! Given it’s homeostatic perhaps should go for one exclamation mark! genesdev.cshlp.org/content/earl...

Grab a pint and listen to this. What a story youtu.be/29abxJgCyOI?...

Kudos to @science.org for this self-analysis of the peer review process. These kind of data are never shared and don't have to be. Wildly refreshing to see it out in the open. Editorial and peer review dynamics at elite general science journals | Science Advances www.science.org/doi/10.1126/...

Send this to whoever is currently posting migrant invasion content to your timeline mrandrewfox.substack.com/p/ceutas-pha...

Job alert! I'm recruiting a new post-doc to work on mechanisms of co-translational quality control in the ER. Looking for expertise in ribosome biology and yeast genetics/cell biology. Please reach out to me with any questions. www.dundee.ac.uk/work-for-us/...

We're looking for a highly motivated Postdoctoral Fellow (Ref. PD/26/11) to join our team at @irbbarcelona.org to study MAPK signaling & conserved stress adaptation mechanisms, using cutting-edge transcriptomics, genomics & proteomics. Apply here: recruitment.irbbarcelona.org/jobs/8135937...

Excited to share this personal story published by @GeneticsGSA. A reflection on my journey in genetics, the many people who shaped it, the @haploteam and my enduring fascination with diversity. Thanks to everyone who has been part of the adventure! academic.oup.com/genetics/adv...

RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...