James Reading

James Reading

@jamesreading.bsky.social

Immunologist | Assoc. Prof at UCL | Using T Cells to Track & Target Tumourigenesis | Cancer Interception | Immune Prevention | https://www.ucl.ac.uk/medical-sciences/divisions/cancer/our-research/pre-cancer-immunology

848 followers842 following8 posts

James Reading
@jamesreading.bsky.social

thanks @nature.com

Nature@nature.com

Nature research paper: A preinvasive regulatory T cell axis for lung cancer interception go.nature.com/4hTQg7x

go.nature.comA preinvasive regulatory T cell axis for lung cancer interception - NatureAn effector regulatory T cell circuit is identified that can be monitored in blood samples to track the development of lung cancer, and blockade of this immune network in the preinvasive setting can intercept tumorigenesis to reduce tumour incidence and size.

James Reading reposted

Fusion Conferences
@fusionconf.bsky.social

#CancerImmuno Announcement📢 📅Final deadline closing this week (Thursday 16th April 2026, Midnight BST!) Register now & join us at the conference! we look forward to welcoming you to Portugal soon!🌞 Click here to register: bit.ly/4tKJVQ5

James Reading
@jamesreading.bsky.social

🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals. ✅ Wet & dry lab ✅ September 2025 enrolment ✅ UK tuition fees only www.ucl.ac.uk/medical-scie...

ucl.ac.ukPre-Cancer ImmunologyThe Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.

James Reading reposted

Jon Lim, FRCP PhD
@drjonlim.bsky.social

🚨 Final day to send in your application to join @giampazolias.bsky.social & the Cancer Immunosurveillance group @cruk-mi.bsky.social. Don’t miss this great opportunity! @mcrcnews.bsky.social

Cancer Research UK Manchester Institute@cruk-mi.bsky.social

We are recruiting #postdoctoral scientists to join @giampazolias.bsky.social and our Cancer Immunosurveillance group 🧪🥼🧫🦠 For full details of the position, please visit our website: www.cruk.manchester.ac.uk/career/mi-24... Closing date: 4th April #OncoSky #CanSky #CancerResearch #microbiome

James Reading reposted

Nature
@nature.com

Nature research paper: Clonal driver neoantigen loss under EGFR TKI and immune selection pressures https://go.nature.com/4k6SCQD

go.nature.comClonal driver neoantigen loss under EGFR TKI and immune selection pressures - NatureWe show the evolution of a case of EGFR mutant lung cancer treated with a combination of erlotinib, osimertinib, radiotherapy and a personalized neopeptide vaccine targeting somatic mutations, including EGFR exon 19 deletion.

James Reading reposted

Santiago Zelenay
@santiagozelenay.bsky.social

Interested in investigating the principles that regulate the establishment of tumour environments that promote or inhibit the anti-tumour function of the immune system? Our group is currently recruiting a postdoctoral fellow. Learn more about our research 👇 www.cruk.manchester.ac.uk/research-gro...

cruk.manchester.ac.ukMI/25/01 – Postdoctoral Scientist – Cancer Inflammation And Immunity Group | Cancer Research UK Manchester Institute

James Reading reposted

Wolfgang Huber
@wkhuber.bsky.social

How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3) doi.org/10.1038/s415...

doi.orgAnalysis of multi-condition single-cell data with latent embedding multivariate regression - Nature GeneticsLatent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...

James Reading reposted

Thiago Carvalho
@cyrilpedia.bsky.social

Interesting work, it's becoming clear that @santiagozelenay.bsky.social's 2015 work on the COX-PGE axis' role in tumor immune evasion is robust (and also that we really need to focus on type I IFN in anti-tumor immunity). #Immunology #Immunotherapy #Immunosky

cell.comCyclooxygenase-Dependent Tumor Growth through Evasion of ImmunityCyclooxygenase-driven prostaglandin E2, produced by a variety of tumors, drives malignant growth through successful evasion of type I interferon and/or T-cell-dependent tumor elimination. A remarkable synergy between cyclooxygenase inhibitors and checkpoint blockade immunotherapy results in tumor eradication.
Anna Obenauf@obenaufa.bsky.social

Thrilled to share that our paper www.nature.com/articles/s41... is featured in a fantastic Nature News & Views piece by thomastueting.bsky.social! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. www.nature.com/articles/d41... 👀👉 rdcu.be/d3cRz

nature.comA lipid made by tumour cells reprograms immune cellsInsights into how cancer cells become unresponsive to therapy.

James Reading reposted

Kris Laukens
@krislaukens.bsky.social

🚀 Advancing T-cell receptor (TCR) research! We developed tcrBLOSUM, a specialized substitution matrix for sensitive alignment of distant epitope-specific TCRs. Find out how our findings expand TCR analysis: doi.org/10.1093/bib/... #Bioinformatics #Immunology #AIRR with @pmeysman.bsky.social

doi.orgtcrBLOSUM: an amino acid substitution matrix for sensitive alignment of distant epitope-specific TCRsAbstract. Deciphering the specificity of T-cell receptor (TCR) repertoires is crucial for monitoring adaptive immune responses and developing targeted immu
James Reading
@jamesreading.bsky.social

Wonderful work @barralab.bsky.social on the role of NKT cells in gut epithelial cell homeostasis. Huge congrats to Patricia, the team and @martalebrusant.bsky.social a rising unconventional T cell superstar that we are lucky to have slaying it in our lab!

Barral Lab@barrallab.bsky.social

Our first 🦋 post! Very happy to share our latest paper just out in Cell Reports, exploring the crosstalk between immune and epithelial cells in the gut. Check it out! @vivianlilab.bsky.social @kingscollegelondon.bsky.social www.cell.com/cell-reports...

cell.comIFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cellsThe crosstalk between immune and epithelial cells is vital to maintain intestinal homeostasis. Lebrusant-Fernandez et al. identify NKT cells in the small intestine as key regulators of epithelial biol...

James Reading reposted

Barral Lab
@barrallab.bsky.social

Our first 🦋 post! Very happy to share our latest paper just out in Cell Reports, exploring the crosstalk between immune and epithelial cells in the gut. Check it out! @vivianlilab.bsky.social @kingscollegelondon.bsky.social www.cell.com/cell-reports...

cell.comIFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cellsThe crosstalk between immune and epithelial cells is vital to maintain intestinal homeostasis. Lebrusant-Fernandez et al. identify NKT cells in the small intestine as key regulators of epithelial biol...

James Reading reposted

E John Wherry
@ejohnwherry.bsky.social

Totally agree. The immune system is an excellent biosensor and recorder of past experiences. UPenn Immune Health www.med.upenn.edu/immunehealth/ together with our Colton Autoimmunity Consortium www.coltonconsortium.org is profiling Immune Health of 1000's of subjects. Many ways to work towards a GIO

med.upenn.eduImmune Health Project | Immune Health | Perelman School of Medicine at the University of PennsylvaniaWe are delighted to introduce the establishment of the Institute for Immunology & Immune Health (I3H), a reorganization of the Institute for Immunology (IFI) and Immune Health, led by E. John Wherry, PhD and Allie Greenplate, PhD.
Michael Mina MD,PhD@michaelmina.bsky.social

We should of course also be developing immunological approaches to study exposures - which are considerably better for understanding pathogen spread and incidence than direct virus tests. Our immune memories hold immense information on exposures! elifesciences.org/articles/589... 15/

elifesciences.orgFigures and data in Science Forum: A Global lmmunological Observatory to meet a time of pandemicsThe COVID-19 pandemic has clearly demonstrated the need for a global system to monitor the dynamics of susceptibility and immunity, as well as infection, during epidemics and pandemics.

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