Joe Beckwith

Joe Beckwith

@jsbeckwith.bsky.social

Spectroscopist, microscopist, pessimist. Assistant Professor in Chemistry at the University of Warwick. Science and/or nonsense. Occasionally a post about personal matters, instantly regretted. he/him | 🏳️‍🌈

563 followers326 following34 posts

Joe Beckwith reposted

Last call!

LGBTQ+ STEM@lgbtqstem.bsky.social

Some updates!! We have a full slate of speakers which can be found here: sites.google.com/view/lgbtqst... We are also coming up on the registration deadline! Please register or encourage others to register by 6 October! Also we made this digital flyer to display or distribute as you see fit. 🏳️‍⚧️🏳️‍🌈

Joe Beckwith reposted

rich dudes got freakier after butlers fell out of fashion, like say what you will about having domestic servants but clearly it was some sort of moderating force on old rich dudes having a fancy man follow you around saying shit like "oh dear sir, that wouldn't be very becoming"

Joe Beckwith reposted

Please share: The application for Les Houches is open (until Oct 31) fluorescenceleshouches.wordpress.com *This is for you, if you ever wanted to learn all about fluorescence markers & how to apply them for your biological research!* PS: no fees this year, you just need to get there, that's all!

fluorescenceleshouches.wordpress.comFrench-German WE-Heraeus-Seminar "Fluorescence markers for advanced microscopy : From photophysics to biology - 2026"March 15-20 2026, Les Houches, France

Joe Beckwith reposted

I am finding the fact that "is it acceptable and proportional to call for trans women to be assaulted in public" is now a subject of public debate in the UK really very upsetting.

Joe Beckwith reposted

Joe Beckwith reposted

Joe Beckwith reposted

Cool work from a cool lab!

Susan Cox@micoxscopy.bsky.social

How do you quantify cell structures which are deformed between different observations? Our preprint shows how to perform Simultaneous QUAntification of Structure and Structural Heterogeneity (SQUASSH) on 3D fluorescence microscopy data. (1/5) www.biorxiv.org/content/10.1...

Joe Beckwith reposted

Excited to share some recent work tracking the 3D movement of individual molecules inside the organelles of living cells (💡+ 🦠 + ⚽️💨) with the best team @joechambers.bsky.social @jamesdmanton.bsky.social @jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social

bioRxiv Biophysics@biorxiv-biophys.bsky.social

Volumetric single-molecule tracking inside subcellular structures https://www.biorxiv.org/content/10.1101/2025.06.09.658280v1

Joe Beckwith reposted

The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology. Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available. ! Please share widely !

Joe Beckwith reposted

A fringe group of bigoted weirdos have dragged British media, government, and law into their hateful obsession with trans people. Grim, depressing, and dangerous. Everyone with power in the UK who's played along should be ashamed of themselves.

Joe Beckwith reposted

Just had the pleasure to experiment with a camera targeting the astronomy market, but offering great value for microscopy. Cooled, low noise (<1.5 e read-noise), high QE cameras that work with Micro-Manager can be bought for ~$1k: nicost.github.io/microscope-t...

nicost.github.ioPlayerOne cooled CMOS cameraThe Sony STARVIS and STARVIS2 image sensors are back-illuminated, have high QE and low readnoise (where STARVIS2 increases full well depth over STARVIS). Even though these sensors are marketed towards...

Joe Beckwith reposted

A bit late to the party, but we (Cambridge Queer in Chemistry Network) put up some posters of inspirational LGBT scientists for LGBT history month! With all that's going on, we hope it brings a little bit of joy. 🏳️‍🌈

Joe Beckwith reposted

Thanks to the more than *1100* members of the scientific community who have signed the letter to insist that the Royal Society remains true to values that we all hold dear but that Musk FRS has ridden roughshod over. Please keep signing & sharing. docs.google.com/forms/d/e/1F...

docs.google.comOpen letter to the President of the Royal Society – time to stand up for your valuesIf you wish to show your support for the letter below regarding apparent inaction by the Royal Society in the face of breaches of its code of conduct by Elon Musk FRS, please sign below. I invite anyo...

Joe Beckwith reposted

“This is bad, full stop. It creates a class of person who are forever excluded from civic life no matter how long they live here. It’s also a clear breach of the refugee convention.” Damn straigt, @colinyeo.bsky.social www.theguardian.com/politics/202...

theguardian.comUK to refuse citizenship to refugees who have ‘made a dangerous journey’Home Office accused of shutting out refugees, as new guidance says those applicants will ‘normally be refused’

Joe Beckwith reposted

In today’s news, American tech billionaire who has cuddled up to an adjudicated sexual predator is lecturing the UK govt on how it deals with sexual predators.

Joe Beckwith reposted

First paper out of my postdoc has just dropped! We map the 3D spatial relationship of PSD95 in mouse brain using DHPSF super-resolution microscopy… and in just enough time for the last #FluorescenceFriday before Christmas! 🎄 pubs.acs.org/doi/10.1021/...

pubs.acs.org3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse BrainPSD95 is an abundant scaffolding protein that assembles multiprotein complexes controlling synaptic physiology and behavior. Confocal microscopy has previously shown that PSD95 is enriched in the postsynaptic terminals of excitatory synapses and two-dimensional (2D) super-resolution microscopy further revealed that it forms nanoclusters. In this study, we utilized three-dimensional (3D) super-resolution microscopy to examine the nanoarchitecture of PSD95 in the mouse brain, characterizing the spatial arrangement of over 8 million molecules. While we were able to identify molecular arrangements that have been previously reported, imaging in 3D allowed us to classify these with higher accuracy. Furthermore, 3D super-resolution microscopy enabled the quantification of protein levels, revealing that an abundance of PSD95 molecules existed outside of synapses as a diffuse population of supercomplexes, containing multiple copies of PSD95. Further analysis of the supercomplexes containing two units identified two populations: one that had PSD95 molecules separated by 39 ± 2 nm, and a second with a separation of 94 ± 27 nm. The finding that there exists supercomplexes containing two PSD95 units outside of the synapse suggests that supercomplexes containing multiple protein copies assemble outside the synapse and then integrate into the synapse to form a supramolecular nanocluster architecture.