Olga Rosspopoff

I’m very happy to share that part of my postdoc work is now out in Science Advances! We find that a chimp-specific endogenous retrovirus (PTERV1) insertion silences LINC00662 and that silencing this lncRNA alters neuronal maturation in neural organoids 🧬🧠🐒 1/6 www.science.org/doi/10.1126/...

Hello World ! Its pre-print time ! Awesome collaboration led by Michel Cohen-Tannoudji (not on Bsky) and the one and only @deborahbourchis.bsky.social. #BFF We solved the molecular mechanism underlying a mysterious hybrid incompatibility in mice: the DDK syndrome. 🧵🍿 www.biorxiv.org/content/10.6...

Now online! SPARCS enables scalable recovery of complex image-based phenotypes for genetic screening

Excited and grateful to have received a grant from @bwstiftung.bsky.social to study how the epitranscriptome impacts epigenome maintenance across cell division🤝🧑‍🔬⚖️ Kudos to Boyang in the lab for spearheading this project!💪🙌

Thrilled to see this published today! Truly special because we made the initial discovery >15 yrs ago! We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic! www.science.org/doi/10.1126/... 🧵1/n

Fold Spacer lets you fly through protein structures (Weekend project #2). It’s my first game: I originally set out to build a racer with structures as the tracks, but was a little too crazy. So it became this instead. You can upload your own structures. 🌐 martin-steinegger.github.io/Fold-Spacer/

How do transposons jump when they’re released from host control? I babysat two chromosomes for 2 years, making sure they are ok without most piRNAs. Here’s what we found & excited to share my 1st postdoc paper: “piRNA loss unleashes episodic transposition bursts” www.biorxiv.org/content/10.6...

From NASA: It happened again! Here's Phobos passing in front of the Sun as seen by the Perseverance rover from the surface of Mars on Aug. 12. science.nasa.gov/photojournal...

Insights from multiple #species are starting to reveal why #menopause evolved. Researchers are considering fresh theories about the #evolution of the change. A PNAS News Feature: https://ow.ly/httx50ZEN17 #gorillas #orcas #chimps #InclusiveFitness #GrandmotherHypothesis #cooperation #competition

📣 Abstract submission deadline for CSHL TEs extended to July 24! Two more weeks to submit your abstract for a short talk or poster — do it! It’s gonna be a fantastic meeting!! meetings.cshl.edu/meetings.asp...

Thank you to organisers to James Hombría and Antónia Monteiro @monteirolab.bsky.social and everyone who joined us at this week's Workshop on 'Novelty, Co-option and Divergence During Gene Network Evolution' biologists.com/workshops #BiologistsWorkshops

New preprint! We show that cell fate can be predicted from a snapshot of combinatorial signaling — and the underlying map is a single angle in signaling space. Work by first authors Bassit Fijabi and Seth Teague and collaboration with @davidbrueckner.bsky.social. www.biorxiv.org/content/10.6...

Two new papers 📖 from our lab 1️⃣ What is epigenetics (and why X inactivation is?) rdcu.be/fhzSz and 2️⃣ A Baculovirus-based tool to express any gene of interest with high efficiency in Anopheles cells rdcu.be/fhzTy

#RIP Pierre Chambon (1931-2026) via @alainberetz.bsky.social one of the last giants in biology: PARP, nuclear receptors, RNA Pol II, nucleosome, promoters, split genes

But wait! There’s more! So you thought you knew nucleosome structure? Think again! @vram142.bsky.social @gladstoneinst.bsky.social and @genophoria.bsky.social @arcinstitute.org show that there is plenty of distortion largely due to TFs butting in www.nature.com/articles/s41...

now published at BMC Biology! rdcu.be/fdITD

Really happy to share that our preprint is now published in @narjournal.bsky.social! 🎉

Our latest publication is now out at Genome Biology! link.springer.com/article/10.1... We uncover a unique association between a H3K27me3 reader complex and active transcription. A thread with our key findings: (1/8) #TEsky #Polycomb #transcription #smallRNAs

Very happy to have been selected for the Young investigator award ✨ See you in Copenhangen folks ! Many thanks to @official-smbe.bsky.social !!

I'm so happy to share our latest paper! Now out in @narjournal.bsky.social 🥳 Did you know that transposable elements embedded in mRNAs can form dsRNA and activate innate immunity? 🧬🦠 Have a look! academic.oup.com/nar/article/... #TEsky #RNAsky #RNAbiology #immunity #NAR

I'm looking for a Swiss department to host me for an SNSF Starting Grant. I research how gene expression evolves and emerges by combining wet lab + computational work in a variety of model systems (E. coli, Drosophila, yeast). More: timothyfuqua.com If your department might be a match, let’s chat!

⚡👩‍🔬Electrical signals are key for promoting organ regenerative growth, a new study! Out now in Science Advances, from the Mateus group @ritamateus.bsky.social at PoL and @mpi-cbg.de along with the lab of Frank Jülicher @mpipks.bsky.social Read the news here: tud.link/7jzptz Video:©️ Mateus group

This feeling of panic when university tells you that ordering system will undergo change+you cannot order for 10 days 😰Tried to order primers ahead of time but as new data come in, I feel paralyzed to not react+plan follow-up experiments😆 Even after being PI for 17yrs, my❤️ for science never changed!

It is finally out! If you are interested in TE-derived CREs, and newly described, but evolutionary old KZFP-TE mechanistic modalities, read it at www.cell.com/cell-reports.... Thankful to everyone who took part in this work, namely @orpsf.bsky.social and other @trono-lab.bsky.social members. 🫀🧬✨

🚨 The final version is out: how transposons help keep our hearts beating ❤️ Proud of this one with @1995dana.bsky.social, huge thanks to @trono-lab.bsky.social. Give it a read! #TEsky

New paper: Remodeling of XIST regulatory landscape during primate evolution We are glad to share with you our latest publication investigating the evolution of XIST regulation in primates ES cells. urlr.me/eyG38M @manucazottes.bsky.social @crougeulle.bsky.social @charbel-alfeghaly.bsky.social

We are very excited to see this work out in its final form at Ultramicroscopy! Knife edge measurements of beam shapes and improved scanned versus shaped beam material removal comparisons. Find the OA article here: doi.org/10.1016/j.ul...

Our work on #RegulatoryTrajectories is out today in Nat. Comms: www.nature.com/articles/s41... Led by @raquelrouco.bsky.social, this study establishes a new framework to study how enhancer landscapes act sequentially at developmental loci and are silenced to shape gene expression patterns. (1/n)

Christmas has come early. Fantastic to see this beautiful study from Peter Rugg-Gunn's lab at The Babraham Institute published today. Congratulations to Matteo Mole, Sarah Elderkin, Irene Zorzan and all other authors! www.cell.com/cell/fulltex...

🚨Our story is published! Same bones but + dissection of MERVL’s role integrating signals from #ZGA factors, & + about pathological DUX4 activation of NOXA #TEsky. Thanks to all revs for their helpful comments improving the ms. Even #rev3 - until they ghosted us 😜 www.science.org/doi/epdf/10....

🚨 New paper out! A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development Here is the full paper: rdcu.be/eSWEs 🧵 A twittorial: THREAD

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉 We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

Join us for the 2026 Glycolipid & Sphingolipid Biology Gordon Research Conference (GRC). 📍 Renaissance Tuscany Il Ciocco (Italy) 🗓️ March 22 - 27, 2026 Theme: "Molecular Codes of Cell Identity and Recognition" #LipidResearch #Sphingolipids #GRC2026 #ScienceConference #Lipidtime

Attending #EMBOevoChromo25 next week? Our Reviews Editor @ingridtsang.bsky.social will be attending - feel free to talk to her about the journal or @biologists.bsky.social activities!

The new issue @cp-devcell.bsky.social brings the final form of our opossum heterochrony work www.cell.com/developmenta... And it also brings two great papers from @oliveringe.bsky.social @santoslab.bsky.social and @tobyandrews.bsky.social @rashmi-priya.bsky.social 🙌 great #DevBio from @crick.ac.uk

Happy to present TOGA2, developed by Yury Malovichko @ymalovichko.bsky.social, the faster, memory-efficient & more accurate TOGA1 successor (github.com/hillerlab/TO...). And annotations, orthologs & gene loss/dup data generated with 4 references for 883 placental mammal and with 5 refs for 676 ...

Check out our latest issue where we interview Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard University. www.cell.com/current-biol...

TE x ZFP = Evolution! Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.

Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social #TEsky #TEworldwide authors.elsevier.com/c/1m6MC,LqAZ...

Welcome to Day 3 of #EMBOMobileGenome 🙌🏼 While this morning's session is already underway, here's a few snaps from yesterday's 🔸last minute breakthrough talk 🔸 ➡️ 'Transposable element co-option drives transcription factor neofunctionalization' presented by Olga Rosspopoff (EPFL, Switzerland)

Had an absolute blast presenting my “Last Minute Breakthrough talk” at #EMBOmobilegenome today! 🔥 What an incredible crowd, the energy in the room was unreal. Huge thanks to the organizers for selecting me and to everyone who came, asked questions, and made it such a fun session! 🙌

An iPSC-derived heart muscle cell assembling sarcomeres videoed through a spinning disk confocal microscope by Burnette Lab graduate student, Emma Koory. Alpha-actinin-2 is shown. Colors denote Z slices (red-bottom; green-middle; blue-top). Movie length- 40 hours.

Welcome to Day 1 of 'The mobile genome: genetic and physiological impacts of transposable elements'! 🧬 The opening remarks by Julius Brennecke accompanied by his fellow scientific organisers: 🔹Déborah Bourc'his 🔹Josefa González 🔹Joseph Peters #EMBOMobileGenome

“The bad review will come from your list of suggested reviewers”

Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩 We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species ➡️ www.biorxiv.org/content/10.1...

📣 New preprint! Stoked to share a fantastic collaboration with @campaslab.bsky.social! We discover a unique mammalian mechanism for body axis elongation using mouse and human gastruloids, and confirm central findings in mouse embryos. Check out the 🧵 👇 @mpi-cbg.de @poldresden.bsky.social

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...